Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BMPR2
  • Mouse genes Bmpr2
  • Rat genes Bmpr2
  • Zfish genes bmpr2a,bmpr2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bmpr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036122	BMP binding	BMPR2	IPI	UniProtKB:O00238	Human	PMID:21976273
Molecular Function	GO:0036122	BMP binding	BMPR2	IPI	UniProtKB:P36894	Human	PMID:21976273
Molecular Function	GO:0036122	BMP binding	Bmpr2	IDA		Mouse	PMID:21976273
Molecular Function	GO:0098821	BMP receptor activity	BMPR2	IDA		Human	PMID:19366699
Molecular Function	GO:0098821	BMP receptor activity	Bmpr2	IMP		Mouse	MGI:MGI:5751611|PMID:26774823
Molecular Function	GO:0098821	BMP receptor activity	Bmpr2	IDA		Mouse	PMID:21976273
Molecular Function	GO:0045296	cadherin binding	BMPR2	IPI	UniProtKB:P33151	Human	PMID:26598555
Molecular Function	GO:0019838	growth factor binding	Bmpr2	IDA		Rat	PMID:11044210|RGD:5129485
Molecular Function	GO:0019209	kinase activator activity	BMPR2	IDA		Human	PMID:19366699
Molecular Function	GO:0016301	kinase activity	BMPR2	IDA		Human	PMID:19366699
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:P12644	Human	PMID:12045205
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:P08607	Human	PMID:15188402
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:P68404	Human	PMID:15188402
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:Q03135-1	Human	PMID:15657086
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:Q03135-2	Human	PMID:15657086
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:P43026	Human	PMID:19229295
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:Q13976	Human	PMID:19424179
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:P43026	Human	PMID:21976273
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:Q13253	Human	PMID:21976273
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:Q9ULZ3	Human	PMID:24407287
Molecular Function	GO:0005515	protein binding	BMPR2	IPI	UniProtKB:Q8IX30	Human	PMID:33308444
Molecular Function	GO:0005515	protein binding	Bmpr2	IPI	UniProtKB:P0C605	Mouse	MGI:MGI:5508584|PMID:19424179
Molecular Function	GO:0005515	protein binding	Bmpr2	IPI	UniProtKB:Q60902	Mouse	PMID:16923969
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Bmpr2	IDA		Mouse	PMID:21976273
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Bmpr2	IMP		Mouse	PMID:11714695
Molecular Function	GO:1990782	protein tyrosine kinase binding	BMPR2	IPI	UniProtKB:P12931	Human	PMID:26598555
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	bmpr2a	IDA		Zfish	PMID:18222420
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	bmpr2b	IDA		Zfish	PMID:18222420
Cellular Component	GO:0005912	adherens junction	BMPR2	IDA		Human	PMID:25468996
Cellular Component	GO:0016324	apical plasma membrane	Bmpr2	IDA		Rat	PMID:16271518|RGD:5129481
Cellular Component	GO:0030424	axon	Bmpr2	IDA		Mouse	PMID:17634368
Cellular Component	GO:0009925	basal plasma membrane	Bmpr2	IDA		Rat	PMID:16271518|RGD:5129481
Cellular Component	GO:0005901	caveola	BMPR2	IMP		Human	PMID:15657086
Cellular Component	GO:0005901	caveola	Bmpr2	IDA		Rat	PMID:16271518|RGD:5129481
Cellular Component	GO:0044297	cell body	Bmpr2	IDA		Mouse	PMID:17634368
Cellular Component	GO:0009986	cell surface	BMPR2	IDA		Human	PMID:23669347
Cellular Component	GO:0009986	cell surface	Bmpr2	IDA		Mouse	PMID:12117821
Cellular Component	GO:0005905	clathrin-coated pit	Bmpr2	IDA		Mouse	PMID:16923969
Cellular Component	GO:0005737	cytoplasm	Bmpr2	IDA		Rat	PMID:16271518|RGD:5129481
Cellular Component	GO:0030425	dendrite	Bmpr2	IDA		Mouse	PMID:17634368
Cellular Component	GO:0030425	dendrite	Bmpr2	IDA		Rat	PMID:21185359|RGD:5129479
Cellular Component	GO:0005615	extracellular space	BMPR2	HDA		Human	PMID:22664934
Cellular Component	GO:0043025	neuronal cell body	Bmpr2	IDA		Rat	PMID:21185359|RGD:5129479
Cellular Component	GO:0005654	nucleoplasm	BMPR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	BMPR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	BMPR2	IDA		Human	PMID:12045205
Cellular Component	GO:0005886	plasma membrane	BMPR2	IDA		Human	PMID:15657086
Cellular Component	GO:0005886	plasma membrane	BMPR2	IDA		Human	PMID:25187962
Cellular Component	GO:0005886	plasma membrane	Bmpr2	IDA		Mouse	PMID:23041979
Cellular Component	GO:0005886	plasma membrane	Bmpr2	IDA		Mouse	PMID:21976273
Cellular Component	GO:0005886	plasma membrane	Bmpr2	IDA		Mouse	PMID:23676498
Cellular Component	GO:0014069	postsynaptic density	Bmpr2	IDA		Mouse	PMID:17114649
Biological Process	GO:0009952	anterior/posterior pattern specification	Bmpr2	IGI	MGI:MGI:87912	Mouse	PMID:15542835
Biological Process	GO:0009952	anterior/posterior pattern specification	Bmpr2	IMP	MGI:MGI:2158503	Mouse	PMID:10772805
Biological Process	GO:0003176	aortic valve development	Bmpr2	IMP	GO:1905314	Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0060840	artery development	Bmpr2	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0060413	atrial septum morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:3851675|PMID:19409885
Biological Process	GO:0001974	blood vessel remodeling	Bmpr2	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0030509	BMP signaling pathway	BMPR2	IMP		Human	PMID:12045205
Biological Process	GO:0030509	BMP signaling pathway	BMPR2	IGI	UniProtKB:P12643	Human	PMID:18382765
Biological Process	GO:0030509	BMP signaling pathway	BMPR2	IDA		Human	PMID:18436533
Biological Process	GO:0030509	BMP signaling pathway	BMPR2	IMP		Human	PMID:19366699
Biological Process	GO:0030509	BMP signaling pathway	BMPR2	IMP		Human	PMID:9442116
Biological Process	GO:0030509	BMP signaling pathway	Bmpr2	IMP		Mouse	MGI:MGI:5751611|PMID:26774823
Biological Process	GO:0030509	BMP signaling pathway	Bmpr2	IMP		Mouse	MGI:MGI:3799581|PMID:18552156
Biological Process	GO:0030509	BMP signaling pathway	Bmpr2	IDA		Mouse	PMID:21976273
Biological Process	GO:0030509	BMP signaling pathway	Bmpr2	IMP		Mouse	PMID:17472960
Biological Process	GO:0030509	BMP signaling pathway	bmpr2a	IMP		Zfish	PMID:18222420
Biological Process	GO:0030509	BMP signaling pathway	bmpr2b	IMP		Zfish	PMID:18222420
Biological Process	GO:0007420	brain development	Bmpr2	IEP		Rat	PMID:8854897|RGD:2315951
Biological Process	GO:0071773	cellular response to BMP stimulus	BMPR2	IMP		Human	PMID:18326817
Biological Process	GO:0009267	cellular response to starvation	BMPR2	IEP		Human	PMID:15657086
Biological Process	GO:0002063	chondrocyte development	BMPR2	IMP		Human	PMID:9442116
Biological Process	GO:0007368	determination of left/right symmetry	bmpr2a	IMP	ZFIN:ZDB-MRPHLNO-080722-6	Zfish	PMID:18222420
Biological Process	GO:0007368	determination of left/right symmetry	bmpr2a	IMP	ZFIN:ZDB-MRPHLNO-080722-6	Zfish	PMID:20549745
Biological Process	GO:0007368	determination of left/right symmetry	bmpr2a	IGI	ZFIN:ZDB-MRPHLNO-080722-6,ZFIN:ZDB-MRPHLNO-080722-8	Zfish	PMID:18222420
Biological Process	GO:0007368	determination of left/right symmetry	bmpr2a	IMP		Zfish	PMID:18222420
Biological Process	GO:0007368	determination of left/right symmetry	bmpr2b	IGI	ZFIN:ZDB-MRPHLNO-080722-6,ZFIN:ZDB-MRPHLNO-080722-8	Zfish	PMID:18222420
Biological Process	GO:0007368	determination of left/right symmetry	bmpr2b	IMP	ZFIN:ZDB-MRPHLNO-080722-8	Zfish	PMID:18222420
Biological Process	GO:0007368	determination of left/right symmetry	bmpr2b	IMP		Zfish	PMID:18222420
Biological Process	GO:0003197	endocardial cushion development	Bmpr2	IMP		Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0072577	endothelial cell apoptotic process	BMPR2	IMP		Human	PMID:25187962
Biological Process	GO:0001935	endothelial cell proliferation	BMPR2	IMP		Human	PMID:25187962
Biological Process	GO:0031101	fin regeneration	bmpr2b	IMP	ZFIN:ZDB-GENO-220318-11	Zfish	PMID:33060133
Biological Process	GO:0031101	fin regeneration	bmpr2a	IMP	ZFIN:ZDB-GENO-220318-11	Zfish	PMID:33060133
Biological Process	GO:0003146	heart jogging	bmpr2a	IMP	ZFIN:ZDB-MRPHLNO-080722-6	Zfish	PMID:18222420
Biological Process	GO:0003146	heart jogging	bmpr2a	IMP	ZFIN:ZDB-MRPHLNO-080722-5	Zfish	PMID:18222420
Biological Process	GO:0003146	heart jogging	bmpr2b	IMP	ZFIN:ZDB-MRPHLNO-080722-7	Zfish	PMID:18222420
Biological Process	GO:0003146	heart jogging	bmpr2b	IMP	ZFIN:ZDB-MRPHLNO-080722-8	Zfish	PMID:18222420
Biological Process	GO:0001947	heart looping	bmpr2a	IMP	ZFIN:ZDB-MRPHLNO-080722-6	Zfish	PMID:18222420
Biological Process	GO:0001947	heart looping	bmpr2a	IMP	ZFIN:ZDB-MRPHLNO-080722-5	Zfish	PMID:18222420
Biological Process	GO:0001947	heart looping	bmpr2b	IMP	ZFIN:ZDB-MRPHLNO-080722-8	Zfish	PMID:18222420
Biological Process	GO:0001947	heart looping	bmpr2b	IMP	ZFIN:ZDB-MRPHLNO-080722-7	Zfish	PMID:18222420
Biological Process	GO:0060173	limb development	Bmpr2	IGI	MGI:MGI:2444521	Mouse	PMID:23610558
Biological Process	GO:0048286	lung alveolus development	Bmpr2	IMP		Mouse	MGI:MGI:3799581|PMID:18552156
Biological Process	GO:0001945	lymph vessel development	bmpr2a	IMP	ZFIN:ZDB-MRPHLNO-110729-2	Zfish	PMID:24608800
Biological Process	GO:0001945	lymph vessel development	bmpr2b	IMP	ZFIN:ZDB-MRPHLNO-110729-3	Zfish	PMID:24608800
Biological Process	GO:0001946	lymphangiogenesis	Bmpr2	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	Bmpr2	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0001893	maternal placenta development	Bmpr2	IMP	MGI:MGI:2158503,MGI:MGI:3576366	Mouse	PMID:23676498
Biological Process	GO:0001707	mesoderm formation	Bmpr2	IMP	MGI:MGI:2158503	Mouse	PMID:10772805
Biological Process	GO:0003183	mitral valve morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:3851675|PMID:19409885
Biological Process	GO:0030308	negative regulation of cell growth	BMPR2	IDA		Human	PMID:12819188
Biological Process	GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:3851675|PMID:19409885
Biological Process	GO:1902731	negative regulation of chondrocyte proliferation	BMPR2	IMP		Human	PMID:9442116
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	BMPR2	IMP		Human	PMID:19366699
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	Bmpr2	IDA		Mouse	PMID:21976273
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	BMPR2	IMP	UniProtKB:P12643	Human	PMID:18382765
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	BMPR2	IMP		Human	PMID:18364108
Biological Process	GO:0045906	negative regulation of vasoconstriction	Bmpr2	IMP		Mouse	MGI:MGI:3799581|PMID:18552156
Biological Process	GO:0048570	notochord morphogenesis	bmpr2a	IMP		Zfish	PMID:18222420
Biological Process	GO:0048570	notochord morphogenesis	bmpr2b	IMP		Zfish	PMID:18222420
Biological Process	GO:0001649	osteoblast differentiation	BMPR2	IMP		Human	PMID:22684006
Biological Process	GO:0001649	osteoblast differentiation	Bmpr2	IDA		Mouse	PMID:7798324
Biological Process	GO:0003151	outflow tract morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:3851675|PMID:19409885
Biological Process	GO:0003148	outflow tract septum morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0048842	positive regulation of axon extension involved in axon guidance	Bmpr2	IMP	UniProtKB:O35607	Mouse	MGI:MGI:5551355|PMID:24052814
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	BMPR2	IMP		Human	PMID:17992660
Biological Process	GO:0030501	positive regulation of bone mineralization	BMPR2	IMP		Human	PMID:18436533
Biological Process	GO:0010595	positive regulation of endothelial cell migration	BMPR2	IMP		Human	PMID:17992660
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	BMPR2	IMP		Human	PMID:17992660
Biological Process	GO:0010634	positive regulation of epithelial cell migration	BMPR2	IDA		Human	PMID:12819188
Biological Process	GO:0010628	positive regulation of gene expression	BMPR2	IMP		Human	PMID:22684006
Biological Process	GO:0045778	positive regulation of ossification	Bmpr2	IMP		Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	BMPR2	IMP		Human	PMID:18436533
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	BMPR2	IMP		Human	PMID:17992660
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	BMPR2	IMP		Human	PMID:19366699
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	BMPR2	IGI	UniProtKB:P12643	Human	PMID:18382765
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	BMPR2	IMP		Human	PMID:12045205
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	BMPR2	IMP		Human	PMID:18326817
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Bmpr2	IMP		Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0003177	pulmonary valve development	Bmpr2	IMP	GO:1905314	Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0042127	regulation of cell population proliferation	BMPR2	IMP		Human	PMID:11502704
Biological Process	GO:1905939	regulation of gonad development	bmpr2a	IMP	ZFIN:ZDB-GENO-220318-2	Zfish	PMID:33060133
Biological Process	GO:1905939	regulation of gonad development	bmpr2a	IMP	ZFIN:ZDB-GENO-220317-18	Zfish	PMID:33060133
Biological Process	GO:1905939	regulation of gonad development	bmpr2a	IMP	ZFIN:ZDB-GENO-220318-4	Zfish	PMID:33060133
Biological Process	GO:0014916	regulation of lung blood pressure	BMPR2	IMP		Human	PMID:18364108
Biological Process	GO:0014916	regulation of lung blood pressure	Bmpr2	IMP		Mouse	MGI:MGI:3799581|PMID:18552156
Biological Process	GO:2000354	regulation of ovarian follicle development	bmpr2a	IMP	ZFIN:ZDB-GENO-220318-4	Zfish	PMID:33060133
Biological Process	GO:2000354	regulation of ovarian follicle development	bmpr2a	IMP	ZFIN:ZDB-GENO-220317-18	Zfish	PMID:33060133
Biological Process	GO:2000354	regulation of ovarian follicle development	bmpr2b	IMP	ZFIN:ZDB-GENO-220318-6	Zfish	PMID:33060133
Biological Process	GO:2000354	regulation of ovarian follicle development	bmpr2a	IMP	ZFIN:ZDB-GENO-220318-2	Zfish	PMID:33060133
Biological Process	GO:0060041	retina development in camera-type eye	Bmpr2	IEP		Rat	PMID:10482474|RGD:5129487
Biological Process	GO:0061298	retina vasculature development in camera-type eye	Bmpr2	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:1905314	semi-lunar valve development	Bmpr2	IMP		Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:1905314	semi-lunar valve development	Bmpr2	IMP		Mouse	MGI:MGI:3851675|PMID:19409885
Biological Process	GO:0007283	spermatogenesis	bmpr2a	IMP	ZFIN:ZDB-GENO-220318-2	Zfish	PMID:33060133
Biological Process	GO:0007283	spermatogenesis	bmpr2a	IMP	ZFIN:ZDB-GENO-220317-18	Zfish	PMID:33060133
Biological Process	GO:0007283	spermatogenesis	bmpr2a	IMP	ZFIN:ZDB-GENO-220318-4	Zfish	PMID:33060133
Biological Process	GO:0002040	sprouting angiogenesis	bmpr2a	IGI	ZFIN:ZDB-GENE-030131-1571,ZFIN:ZDB-GENE-070618-2	Zfish	PMID:25584797
Biological Process	GO:0002040	sprouting angiogenesis	bmpr2a	IGI	ZFIN:ZDB-GENE-030131-7745,ZFIN:ZDB-GENE-070618-2	Zfish	PMID:25584797
Biological Process	GO:0002040	sprouting angiogenesis	bmpr2a	IGI	ZFIN:ZDB-GENE-070618-2	Zfish	PMID:25584797
Biological Process	GO:0002040	sprouting angiogenesis	bmpr2b	IGI	ZFIN:ZDB-GENE-070618-1	Zfish	PMID:25584797
Biological Process	GO:0002040	sprouting angiogenesis	bmpr2b	IGI	ZFIN:ZDB-GENE-030131-7745,ZFIN:ZDB-GENE-070618-1	Zfish	PMID:25584797
Biological Process	GO:0002040	sprouting angiogenesis	bmpr2b	IGI	ZFIN:ZDB-GENE-030131-1571,ZFIN:ZDB-GENE-070618-1	Zfish	PMID:25584797
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	BMPR2	IDA		Human	PMID:12045205
Biological Process	GO:0003186	tricuspid valve morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:3851675|PMID:19409885
Biological Process	GO:0001944	vasculature development	bmpr2a	IGI	ZFIN:ZDB-MRPHLNO-060919-1,ZFIN:ZDB-MRPHLNO-110729-1	Zfish	PMID:22898784
Biological Process	GO:0060841	venous blood vessel development	Bmpr2	IMP		Mouse	MGI:MGI:4436974|PMID:19903896
Biological Process	GO:0060412	ventricular septum morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:2429424|PMID:12441304
Biological Process	GO:0060412	ventricular septum morphogenesis	Bmpr2	IMP		Mouse	MGI:MGI:3851675|PMID:19409885

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern