Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BPI
  • Mouse genes Bpi
  • Rat genes Bpi
  • Zfish genes bpifcl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bpi

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001530	lipopolysaccharide binding	BPI	IDA		Human	PMID:8409400
Molecular Function	GO:0001530	lipopolysaccharide binding	Bpi	IDA		Rat	PMID:15009116|RGD:1303979
Cellular Component	GO:0005737	cytoplasm	Bpi	IDA		Mouse	PMID:15590754
Cellular Component	GO:0005737	cytoplasm	Bpi	IDA		Rat	PMID:15009116|RGD:1303979
Cellular Component	GO:0070062	extracellular exosome	BPI	HDA		Human	PMID:19056867
Biological Process	GO:0042742	defense response to bacterium	Bpi	IDA		Rat	PMID:11445707|RGD:1331346
Biological Process	GO:0006955	immune response	Bpi	IDA		Rat	PMID:11445707|RGD:1331346
Biological Process	GO:0032715	negative regulation of interleukin-6 production	BPI	IDA		Human	PMID:8409400
Biological Process	GO:0032717	negative regulation of interleukin-8 production	BPI	IDA		Human	PMID:8409400
Biological Process	GO:0043031	negative regulation of macrophage activation	BPI	IDA		Human	PMID:8409400
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	BPI	IDA		Human	PMID:8409400

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern