Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRCA2
  • Mouse genes Brca2
  • Rat genes Brca2
  • Zfish genes brca2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brca2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043015	gamma-tubulin binding	BRCA2	IPI	UniProtKB:P23258	Human	PMID:17286961
Molecular Function	GO:0010484	histone H3 acetyltransferase activity	BRCA2	IDA		Human	PMID:9619837
Molecular Function	GO:0010485	histone H4 acetyltransferase activity	BRCA2	IDA		Human	PMID:9619837
Molecular Function	GO:0042802	identical protein binding	BRCA2	IPI	UniProtKB:P51587	Human	PMID:21601571
Molecular Function	GO:0042802	identical protein binding	BRCA2	IPI	UniProtKB:P51587	Human	PMID:25282148
Molecular Function	GO:0002020	protease binding	BRCA2	IPI	UniProtKB:P51784	Human	PMID:15314155
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P60896	Human	PMID:10373512
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:10551859
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:11597317
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P38398	Human	PMID:12242698
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9GKK8	Human	PMID:12242698
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:12442171
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9BXW9	Human	PMID:15115758
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:15800615
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9Y5V3	Human	PMID:15930293
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q8N1V2	Human	PMID:15967112
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P02768	Human	PMID:16099937
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P60896	Human	PMID:16205630
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q8N137	Human	PMID:16275750
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:17420451
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:17515903
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609-1	Human	PMID:17515903
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609-1	Human	PMID:17515904
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:17541404
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q14565	Human	PMID:17541404
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9BXW9	Human	PMID:18212739
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9BXW9-2	Human	PMID:18212739
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:18264088
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:19303847
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:19369211
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:19423707
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:19609323
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:19628690
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P04637	Human	PMID:20421506
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:20729832
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q14565	Human	PMID:20729832
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:20729859
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:21399666
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9P0W2	Human	PMID:21399666
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:21601571
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P60896	Human	PMID:21719596
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:22116401
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:22193777
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P60896	Human	PMID:22293751
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:22293751
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:22293751
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9NTI5	Human	PMID:22293751
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P60896	Human	PMID:24013206
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:24141787
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:24485656
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q9Y253	Human	PMID:24485656
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:25282148
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:25585578
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:26649820
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P28715,UniProtKB:P60896,UniProtKB:Q06609,UniProtKB:Q86YC2	Human	PMID:26833090
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:28319063
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:30410870
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:O75031	Human	PMID:31242413
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q86YC2	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:Q06609	Human	PMID:9560268
Molecular Function	GO:0005515	protein binding	BRCA2	IDA		Human	PMID:9774970
Molecular Function	GO:0005515	protein binding	BRCA2	IPI	UniProtKB:P38398	Human	PMID:9774970
Molecular Function	GO:0005515	protein binding	Brca2	IPI	UniProtKB:Q08297,UniProtKB:Q9D4G2|UniProtKB:Q9D4G2	Mouse	MGI:MGI:6283956|PMID:30760716
Molecular Function	GO:0005515	protein binding	Brca2	IPI	UniProtKB:Q9D4G2	Mouse	MGI:MGI:6456264|PMID:31242413
Molecular Function	GO:0005515	protein binding	Brca2	IPI	UniProtKB:Q6DIA7	Mouse	MGI:MGI:6448646|PMID:32460033
Molecular Function	GO:0005515	protein binding	Brca2	IPI	UniProtKB:Q08297|UniProtKB:Q5SV06|UniProtKB:Q9D513|UniProtKB:Q6DIA7,UniProtKB:Q9D4G2	Mouse	MGI:MGI:6447091|PMID:32345962
Molecular Function	GO:0005515	protein binding	Brca2	IPI	UniProtKB:Q6DIA7,UniProtKB:Q9D4G2	Mouse	MGI:MGI:6515529|PMID:32845237
Molecular Function	GO:0005515	protein binding	Brca2	IPI	PR:Q08297	Mouse	PMID:12893777
Molecular Function	GO:0005515	protein binding	Brca2	IPI	PR:Q08297	Mouse	PMID:15359272
Molecular Function	GO:0005515	protein binding	Brca2	IPI	PR:Q08297	Mouse	PMID:9126738
Molecular Function	GO:0005515	protein binding	Brca2	IPI	PR:P60897	Mouse	PMID:12228710
Molecular Function	GO:0005515	protein binding	Brca2	IPI	PR:Q08297	Mouse	PMID:11477095
Molecular Function	GO:0005515	protein binding	Brca2	IPI	RGD:1349756	Rat	PMID:12228710|RGD:632363
Molecular Function	GO:0003697	single-stranded DNA binding	BRCA2	IDA		Human	PMID:20729832
Molecular Function	GO:0003697	single-stranded DNA binding	Brca2	IDA		Rat	PMID:12228710|RGD:632363
Cellular Component	GO:0033593	BRCA2-MAGE-D1 complex	BRCA2	IDA		Human	PMID:15930293
Cellular Component	GO:0005813	centrosome	BRCA2	IDA		Human	PMID:17286961
Cellular Component	GO:0005813	centrosome	BRCA2	IDA		Human	PMID:21276791
Cellular Component	GO:0005694	chromosome	Brca2	IDA		Mouse	MGI:MGI:6283956|PMID:30760716
Cellular Component	GO:0000781	chromosome, telomeric region	BRCA2	IDA		Human	PMID:21076401
Cellular Component	GO:0005737	cytoplasm	Brca2	IDA		Mouse	PMID:11172592
Cellular Component	GO:0005829	cytosol	BRCA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990391	DNA repair complex	BRCA2	IPI		Human	PMID:19369211
Cellular Component	GO:0000800	lateral element	BRCA2	IDA		Human	PMID:9774970
Cellular Component	GO:0000152	nuclear ubiquitin ligase complex	BRCA2	IDA		Human	PMID:14636569
Cellular Component	GO:0005654	nucleoplasm	BRCA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BRCA2	IDA		Human	PMID:14636569
Cellular Component	GO:0005634	nucleus	BRCA2	IDA		Human	PMID:17286961
Cellular Component	GO:0005634	nucleus	BRCA2	IDA		Human	PMID:26833090
Cellular Component	GO:0005634	nucleus	BRCA2	IDA		Human	PMID:9560268
Cellular Component	GO:0005634	nucleus	BRCA2	IDA		Human	PMID:9774970
Cellular Component	GO:0005634	nucleus	Brca2	IDA		Mouse	PMID:11172592
Cellular Component	GO:0005634	nucleus	Brca2	IDA		Mouse	PMID:11477095
Cellular Component	GO:0032991	protein-containing complex	BRCA2	IDA		Human	PMID:26833090
Cellular Component	GO:0032991	protein-containing complex	BRCA2	IDA		Human	PMID:9774970
Cellular Component	GO:0030141	secretory granule	BRCA2	IDA		Human	PMID:8589722
Biological Process	GO:0007420	brain development	Brca2	IMP	MGI:MGI:2156556,MGI:MGI:2176173	Mouse	PMID:17476307
Biological Process	GO:0008283	cell population proliferation	Brca2	IMP	MGI:MGI:2156556,MGI:MGI:2176173	Mouse	PMID:17476307
Biological Process	GO:0008283	cell population proliferation	Brca2	IMP	MGI:MGI:1930615	Mouse	PMID:9171368
Biological Process	GO:0071479	cellular response to ionizing radiation	BRCA2	IMP		Human	PMID:14636569
Biological Process	GO:0090398	cellular senescence	Brca2	IMP	MGI:MGI:2653913	Mouse	PMID:9699678
Biological Process	GO:0090398	cellular senescence	Brca2	IMP	MGI:MGI:2653914	Mouse	PMID:9699678
Biological Process	GO:0051298	centrosome duplication	BRCA2	IMP		Human	PMID:17286961
Biological Process	GO:0043009	chordate embryonic development	Brca2	IMP	MGI:MGI:1930615	Mouse	PMID:9171368
Biological Process	GO:0051276	chromosome organization	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:9660919
Biological Process	GO:0051276	chromosome organization	Brca2	IMP	MGI:MGI:2448890	Mouse	PMID:16859999
Biological Process	GO:0006974	DNA damage response	Brca2	IDA		Mouse	MGI:MGI:3818835|PMID:12410562
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:8738145
Biological Process	GO:0006310	DNA recombination	Brca2	IDA		Rat	PMID:12228710|RGD:632363
Biological Process	GO:0006302	double-strand break repair	BRCA2	IMP		Human	PMID:16845393
Biological Process	GO:0006302	double-strand break repair	Brca2	IMP	MGI:MGI:2177226	Mouse	PMID:9398843
Biological Process	GO:0006302	double-strand break repair	Brca2	IMP	MGI:MGI:2156556,MGI:MGI:2176173	Mouse	PMID:17476307
Biological Process	GO:0000724	double-strand break repair via homologous recombination	BRCA2	IDA		Human	PMID:20729832
Biological Process	GO:0000724	double-strand break repair via homologous recombination	BRCA2	IMP		Human	PMID:21719596
Biological Process	GO:0000724	double-strand break repair via homologous recombination	BRCA2	IDA		Human	PMID:28398198
Biological Process	GO:0000724	double-strand break repair via homologous recombination	Brca2	IMP	MGI:MGI:2653914	Mouse	PMID:15485900
Biological Process	GO:0000724	double-strand break repair via homologous recombination	Brca2	IMP	MGI:MGI:2653913	Mouse	PMID:15485900
Biological Process	GO:0070200	establishment of protein localization to telomere	BRCA2	IDA		Human	PMID:21076401
Biological Process	GO:0070200	establishment of protein localization to telomere	Brca2	IDA		Mouse	MGI:MGI:5707585|PMID:21076401
Biological Process	GO:0008585	female gonad development	Brca2	IMP	MGI:MGI:2177226	Mouse	PMID:9398843
Biological Process	GO:0008585	female gonad development	brca2	IMP	ZFIN:ZDB-GENO-101130-5	Zfish	PMID:20974951
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Brca2	IMP	MGI:MGI:2448890	Mouse	PMID:16859999
Biological Process	GO:0030097	hemopoiesis	Brca2	IMP	MGI:MGI:2448890	Mouse	PMID:16859999
Biological Process	GO:0031619	homologous chromosome orientation involved in meiotic metaphase I plate congression	Brca2	IMP		Rat	PMID:16964288|RGD:1599505
Biological Process	GO:0001833	inner cell mass cell proliferation	Brca2	IMP	MGI:MGI:1930617	Mouse	PMID:9171369
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Brca2	IGI	MGI:MGI:107202	Mouse	PMID:17476307
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Brca2	IGI	MGI:MGI:98834	Mouse	PMID:17476307
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Brca2	IMP	MGI:MGI:2429691,MGI:MGI:3052655	Mouse	PMID:15735671
Biological Process	GO:0007141	male meiosis I	Brca2	IDA		Mouse	MGI:MGI:6447091|PMID:32345962
Biological Process	GO:0007141	male meiosis I	Brca2	IMP	MGI:MGI:2177233	Mouse	PMID:14660434
Biological Process	GO:0030879	mammary gland development	Brca2	IMP		Rat	PMID:16964288|RGD:1599505
Biological Process	GO:1990426	mitotic recombination-dependent replication fork processing	BRCA2	IMP		Human	PMID:21076401
Biological Process	GO:0035264	multicellular organism growth	Brca2	IMP		Rat	PMID:16964288|RGD:1599505
Biological Process	GO:0043066	negative regulation of apoptotic process	brca2	IMP	ZFIN:ZDB-FISH-210608-12	Zfish	PMID:32284789
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	BRCA2	IDA		Human	PMID:15930293
Biological Process	GO:0006289	nucleotide-excision repair	BRCA2	IMP		Human	PMID:16845393
Biological Process	GO:0001556	oocyte maturation	Brca2	IMP	MGI:MGI:2177233	Mouse	PMID:14660434
Biological Process	GO:0072015	podocyte development	brca2	IMP	ZFIN:ZDB-GENO-181227-8	Zfish	PMID:29707605
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	BRCA2	IDA		Human	PMID:9126734
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:9660919
Biological Process	GO:0048793	pronephros development	brca2	IMP	ZFIN:ZDB-GENO-181227-8	Zfish	PMID:28579318
Biological Process	GO:0032465	regulation of cytokinesis	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:15375219
Biological Process	GO:0031297	replication fork processing	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:14681210
Biological Process	GO:0032355	response to estradiol	Brca2	IEP		Rat	PMID:14583453|RGD:1342419
Biological Process	GO:0010332	response to gamma radiation	Brca2	IMP	MGI:MGI:2653914	Mouse	PMID:9699678
Biological Process	GO:0010332	response to gamma radiation	Brca2	IMP	MGI:MGI:2177233	Mouse	PMID:9126738
Biological Process	GO:0010332	response to gamma radiation	Brca2	IMP	MGI:MGI:2653913	Mouse	PMID:9699678
Biological Process	GO:0007584	response to nutrient	Brca2	IEP		Rat	PMID:14583453|RGD:1342419
Biological Process	GO:0010225	response to UV-C	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:9660919
Biological Process	GO:0010165	response to X-ray	Brca2	IMP	MGI:MGI:2448890	Mouse	PMID:16859999
Biological Process	GO:0010165	response to X-ray	Brca2	IMP	MGI:MGI:2177226	Mouse	PMID:9398843
Biological Process	GO:0010165	response to X-ray	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:9660919
Biological Process	GO:0007530	sex determination	brca2	IMP	ZFIN:ZDB-GENO-121213-3	Zfish	PMID:21483806
Biological Process	GO:0007283	spermatogenesis	Brca2	IMP	MGI:MGI:2177226	Mouse	PMID:9398843
Biological Process	GO:0007283	spermatogenesis	Brca2	IMP		Rat	PMID:16964288|RGD:1599505
Biological Process	GO:0007283	spermatogenesis	brca2	IMP	ZFIN:ZDB-GENO-101130-5	Zfish	PMID:20974951
Biological Process	GO:0072089	stem cell proliferation	Brca2	IMP	MGI:MGI:2177226	Mouse	PMID:9398843
Biological Process	GO:0072089	stem cell proliferation	Brca2	IMP	MGI:MGI:1930616	Mouse	PMID:9660919
Biological Process	GO:0000722	telomere maintenance via recombination	Brca2	IGI	UniProtKB:Q13207	Mouse	MGI:MGI:5707585|PMID:21076401

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern