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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Brcc3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brcc3
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0030234enzyme regulator activityBRCC3IDAHumanPMID:14636569
Molecular FunctionGO:0061578K63-linked deubiquitinase activityBRCC3IDAHumanPMID:19202061
Molecular FunctionGO:0061578K63-linked deubiquitinase activityBRCC3IDAHumanPMID:28943315
Molecular FunctionGO:0140492metal-dependent deubiquitinase activityBRCC3IMPHumanPMID:19261746
Molecular FunctionGO:0140492metal-dependent deubiquitinase activityBrcc3IDAMouseMGI:MGI:7387171|PMID:23246432
Molecular FunctionGO:0008237metallopeptidase activityBRCC3IMPHumanPMID:17525341
Molecular FunctionGO:0008237metallopeptidase activityBRCC3IMPHumanPMID:19214193
Molecular FunctionGO:0008237metallopeptidase activityBRCC3IMPHumanPMID:19261746
Molecular FunctionGO:0031593polyubiquitin modification-dependent protein bindingBRCC3IDAHumanPMID:19261749
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q9NXR7HumanPMID:14636569
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q6UWZ7HumanPMID:18077395
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q96RL1-1HumanPMID:18077395
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q96RL1-1HumanPMID:19202061
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q6UWZ7HumanPMID:19261748
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q9NXR7HumanPMID:19261748
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q6UWZ7HumanPMID:19261749
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:Q6UWZ7HumanPMID:19615732
Molecular FunctionGO:0005515protein bindingBRCC3IPIUniProtKB:X5D778HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingBrcc3IPIUniProtKB:E9Q9M8|UniProtKB:O09106MouseMGI:MGI:6867105|PMID:34180153
Molecular FunctionGO:0005515protein bindingBrcc3IPIPR:Q80WJ1MousePMID:23451117
Molecular FunctionGO:0005515protein bindingBrcc3IPIPR:Q3TCJ1MousePMID:22974638
Cellular ComponentGO:0070531BRCA1-A complexBRCC3IDAHumanPMID:17525341
Cellular ComponentGO:0070531BRCA1-A complexBRCC3IDAHumanPMID:19202061
Cellular ComponentGO:0070531BRCA1-A complexBRCC3IDAHumanPMID:19261746
Cellular ComponentGO:0070531BRCA1-A complexBRCC3IDAHumanPMID:19261748
Cellular ComponentGO:0070531BRCA1-A complexBRCC3IDAHumanPMID:19261749
Cellular ComponentGO:0070552BRISC complexBRCC3IDAHumanPMID:19214193
Cellular ComponentGO:0070552BRISC complexBRCC3IDAHumanPMID:24075985
Cellular ComponentGO:0005737cytoplasmBRCC3IDAHumanPMID:24075985
Cellular ComponentGO:0000152nuclear ubiquitin ligase complexBRCC3IDAHumanPMID:14636569
Cellular ComponentGO:0005654nucleoplasmBRCC3IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusBRCC3IDAHumanPMID:14636569
Cellular ComponentGO:0005634nucleusBRCC3IDAHumanPMID:19202061
Cellular ComponentGO:0000151ubiquitin ligase complexBRCC3IDAHumanPMID:14636569
Biological ProcessGO:0001525angiogenesisbrcc3IMPZFIN:ZDB-MRPHLNO-120215-4ZfishPMID:21596366
Biological ProcessGO:0071479cellular response to ionizing radiationBRCC3IMPHumanPMID:14636569
Biological ProcessGO:0006302double-strand break repairBRCC3IMPHumanPMID:17525341
Biological ProcessGO:0006302double-strand break repairBRCC3IMPHumanPMID:19202061
Biological ProcessGO:0006302double-strand break repairBRCC3IMPHumanPMID:19261746
Biological ProcessGO:0006302double-strand break repairBRCC3IMPHumanPMID:19261748
Biological ProcessGO:0070537histone H2A K63-linked deubiquitinationBRCC3IMPHumanPMID:19261746
Biological ProcessGO:0007095mitotic G2 DNA damage checkpoint signalingBRCC3IMPHumanPMID:17525341
Biological ProcessGO:0007095mitotic G2 DNA damage checkpoint signalingBRCC3IMPHumanPMID:19261746
Biological ProcessGO:0007095mitotic G2 DNA damage checkpoint signalingBRCC3IMPHumanPMID:19261748
Biological ProcessGO:0045739positive regulation of DNA repairBRCC3IMPHumanPMID:17525341
Biological ProcessGO:0045739positive regulation of DNA repairBRCC3IMPHumanPMID:19261746
Biological ProcessGO:0045739positive regulation of DNA repairBRCC3IMPHumanPMID:19261748
Biological ProcessGO:1900227positive regulation of NLRP3 inflammasome complex assemblyBRCC3IDAHumanPMID:28943315
Biological ProcessGO:1900227positive regulation of NLRP3 inflammasome complex assemblyBrcc3IDAMouseMGI:MGI:7387171|PMID:23246432
Biological ProcessGO:0016579protein deubiquitinationBrcc3IDAMouseMGI:MGI:6867105|PMID:34180153
Biological ProcessGO:0070536protein K63-linked deubiquitinationBRCC3IDAHumanPMID:17525341
Biological ProcessGO:0070536protein K63-linked deubiquitinationBRCC3IDAHumanPMID:19214193
Biological ProcessGO:0070536protein K63-linked deubiquitinationBRCC3IMPHumanPMID:24075985
Biological ProcessGO:0070536protein K63-linked deubiquitinationBrcc3IDAMouseMGI:MGI:7387171|PMID:23246432
Biological ProcessGO:0010212response to ionizing radiationBRCC3IMPHumanPMID:17525341
Biological ProcessGO:0010212response to ionizing radiationBRCC3IMPHumanPMID:19261746
Biological ProcessGO:0010212response to ionizing radiationBRCC3IMPHumanPMID:19261748
Biological ProcessGO:0010165response to X-rayBRCC3IDAHumanPMID:14636569

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory