Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRD2
  • Mouse genes Brd2
  • Rat genes Brd2
  • Zfish genes brd2a,brd2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	BRD2	IDA		Human	PMID:18406326
Molecular Function	GO:0070577	lysine-acetylated histone binding	BRD2	IDA		Human	PMID:18406326
Molecular Function	GO:0005515	protein binding	BRD2	IPI	UniProtKB:P62805	Human	PMID:20709061
Molecular Function	GO:0005515	protein binding	BRD2	IPI	UniProtKB:Q13761	Human	PMID:24229708
Molecular Function	GO:0004674	protein serine/threonine kinase activity	BRD2	IDA		Human	PMID:8595877
Cellular Component	GO:0005737	cytoplasm	Brd2	IDA		Mouse	PMID:15063089
Cellular Component	GO:0016607	nuclear speck	BRD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	BRD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BRD2	IDA		Human	PMID:25593309
Cellular Component	GO:0005634	nucleus	BRD2	IDA		Human	PMID:8595877
Cellular Component	GO:0005634	nucleus	Brd2	IDA		Mouse	PMID:15063089
Biological Process	GO:0030902	hindbrain development	brd2a	IMP	ZFIN:ZDB-MRPHLNO-170824-7	Zfish	PMID:28549975
Biological Process	GO:0030902	hindbrain development	brd2a	IMP	ZFIN:ZDB-MRPHLNO-170824-8	Zfish	PMID:28549975
Biological Process	GO:0030917	midbrain-hindbrain boundary development	brd2a	IMP	ZFIN:ZDB-MRPHLNO-170824-7	Zfish	PMID:28549975
Biological Process	GO:0030917	midbrain-hindbrain boundary development	brd2a	IMP	ZFIN:ZDB-MRPHLNO-170824-8	Zfish	PMID:28549975
Biological Process	GO:0001843	neural tube closure	Brd2	IMP	MGI:3840071	Mouse	PMID:19362612
Biological Process	GO:0006334	nucleosome assembly	BRD2	IMP		Human	PMID:18406326
Biological Process	GO:0006468	protein phosphorylation	BRD2	IDA		Human	PMID:8595877
Biological Process	GO:0042981	regulation of apoptotic process	brd2a	IMP	ZFIN:ZDB-MRPHLNO-170824-7	Zfish	PMID:28549975
Biological Process	GO:0010468	regulation of gene expression	Brd2	IMP	MGI:3840071	Mouse	PMID:19362612
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	BRD2	IDA		Human	PMID:18406326
Biological Process	GO:0021510	spinal cord development	brd2a	IMP	ZFIN:ZDB-MRPHLNO-170824-7	Zfish	PMID:28549975
Biological Process	GO:0002574	thrombocyte differentiation	brd2b	IMP	ZFIN:ZDB-MRPHLNO-141013-4	Zfish	PMID:25010335
Biological Process	GO:0002574	thrombocyte differentiation	brd2a	IMP	ZFIN:ZDB-MRPHLNO-141013-3	Zfish	PMID:25010335

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern