Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRD4
  • Mouse genes Brd4
  • Rat genes Brd4
  • Zfish genes brd4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	BRD4	IDA		Human	PMID:20871596
Molecular Function	GO:0003682	chromatin binding	BRD4	IDA		Human	PMID:23317504
Molecular Function	GO:0003682	chromatin binding	Brd4	IDA		Mouse	PMID:23752591
Molecular Function	GO:0003682	chromatin binding	Brd4	IDA		Mouse	PMID:23154982
Molecular Function	GO:0003682	chromatin binding	brd4	IDA		Zfish	PMID:18498094|ZFIN:ZDB-PUB-080527-16
Molecular Function	GO:0003677	DNA binding	Brd4	IDA		Mouse	PMID:16109376
Molecular Function	GO:0019899	enzyme binding	BRD4	IPI	UniProtKB:Q6NYC1	Human	PMID:21555454
Molecular Function	GO:0019899	enzyme binding	BRD4	IPI	UniProtKB:Q9BZ95	Human	PMID:21555454
Molecular Function	GO:0034211	GTP-dependent protein kinase activity	Brd4	IDA		Mouse	PMID:22509028
Molecular Function	GO:0042393	histone binding	brd4	IDA		Zfish	PMID:18498094
Molecular Function	GO:0140566	histone reader activity	BRD4	IDA		Human	PMID:23086925
Molecular Function	GO:0070577	lysine-acetylated histone binding	BRD4	IDA		Human	PMID:20871596
Molecular Function	GO:0070577	lysine-acetylated histone binding	BRD4	IDA		Human	PMID:23086925
Molecular Function	GO:0070577	lysine-acetylated histone binding	BRD4	IDA		Human	PMID:23317504
Molecular Function	GO:0070577	lysine-acetylated histone binding	BRD4	IDA		Human	PMID:29176719
Molecular Function	GO:0106140	P-TEFb complex binding	BRD4	IDA		Human	PMID:24360279
Molecular Function	GO:0002039	p53 binding	BRD4	IDA		Human	PMID:23317504
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P03120	Human	PMID:17023018
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P04015	Human	PMID:17023018
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P06790	Human	PMID:17023018
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P17383	Human	PMID:17023018
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P03122	Human	PMID:17189189
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P03120	Human	PMID:18305892
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q04206	Human	PMID:19103749
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q14839	Human	PMID:21555454
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q96QE3	Human	PMID:21555454
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q9NZM4	Human	PMID:21555454
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q04206	Human	PMID:22645123
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P03120	Human	PMID:22761572
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P04015	Human	PMID:22761572
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P06790	Human	PMID:22761572
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q6NYC1	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q04206	Human	PMID:23686307
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:O60563,UniProtKB:P50750,UniProtKB:Q6NYC1	Human	PMID:24360279
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q6NYC1	Human	PMID:24360279
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q15672	Human	PMID:24525235
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q86YD7	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q6NYC1|UniProtKB:Q9BZ95	Human	PMID:29176719
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q9NZM4	Human	PMID:29374058
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:A6NLX3	Human	PMID:35016035
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:Q86YD7	Human	PMID:35016035
Molecular Function	GO:0005515	protein binding	BRD4	IPI	UniProtKB:P43694	Human	PMID:35182466
Molecular Function	GO:0005515	protein binding	Brd4	IPI	UniProtKB:Q04206	Mouse	MGI:MGI:3835895|PMID:19103749
Molecular Function	GO:0005515	protein binding	Brd4	IPI	PR:P15314	Mouse	PMID:23154982
Molecular Function	GO:0005515	protein binding	Brd4	IPI	UniProtKB:Q7Z2E0	Mouse	PMID:16109376
Molecular Function	GO:0005515	protein binding	Brd4	IPI	UniProtKB:P50750	Mouse	PMID:16109376
Molecular Function	GO:0005515	protein binding	Brd4	IPI	UniProtKB:O60244	Mouse	PMID:16109376
Molecular Function	GO:0005515	protein binding	Brd4	IPI	UniProtKB:O60583	Mouse	PMID:16109376
Molecular Function	GO:0005515	protein binding	Brd4	IPI	PR:Q9CWR2	Mouse	PMID:23752591
Molecular Function	GO:0005515	protein binding	Brd4	IPI	UniProtKB:O60563	Mouse	PMID:16109376
Molecular Function	GO:0005515	protein binding	Brd4	IPI	PR:Q99J95	Mouse	PMID:23154982
Molecular Function	GO:0005515	protein binding	Brd4	IPI	UniProtKB:Q9HA81	Mouse	PMID:16109376
Molecular Function	GO:0099122	RNA polymerase II C-terminal domain binding	BRD4	IDA		Human	PMID:22509028
Molecular Function	GO:0099122	RNA polymerase II C-terminal domain binding	Brd4	IPI	PR:P08775	Mouse	PMID:22509028
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	BRD4	IMP		Human	PMID:22509028
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	Brd4	IMP		Mouse	PMID:22509028
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	Brd4	IDA		Mouse	PMID:22509028
Molecular Function	GO:0000976	transcription cis-regulatory region binding	BRD4	IDA		Human	PMID:23086925
Molecular Function	GO:0003713	transcription coactivator activity	BRD4	IMP		Human	PMID:21555454
Molecular Function	GO:0003712	transcription coregulator activity	BRD4	IMP		Human	PMID:24360279
Cellular Component	GO:0000785	chromatin	Brd4	IDA		Mouse	PMID:16339075
Cellular Component	GO:0000793	condensed chromosome	brd4	IDA		Zfish	PMID:18498094
Cellular Component	GO:0000794	condensed nuclear chromosome	BRD4	IDA		Human	PMID:10938129
Cellular Component	GO:0000794	condensed nuclear chromosome	Brd4	IDA		Mouse	PMID:18039861
Cellular Component	GO:0000794	condensed nuclear chromosome	Brd4	IDA		Mouse	PMID:10938129
Cellular Component	GO:0000794	condensed nuclear chromosome	Brd4	IDA		Mouse	PMID:16339075
Cellular Component	GO:0008024	cyclin/CDK positive transcription elongation factor complex	Brd4	IDA		Mouse	PMID:23752591
Cellular Component	GO:0005654	nucleoplasm	BRD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BRD4	IDA		Human	PMID:20871596
Cellular Component	GO:0005634	nucleus	BRD4	IDA		Human	PMID:25593309
Cellular Component	GO:0005634	nucleus	Brd4	IDA		Mouse	PMID:10938129
Cellular Component	GO:0005634	nucleus	Brd4	IDA		Mouse	PMID:16109376
Cellular Component	GO:0005634	nucleus	brd4	IDA		Zfish	PMID:18498094
Biological Process	GO:0007059	chromosome segregation	Brd4	IMP		Mouse	PMID:16339075
Biological Process	GO:0001833	inner cell mass cell proliferation	Brd4	IMP	MGI:MGI:2674141	Mouse	PMID:11997514
Biological Process	GO:0043388	positive regulation of DNA binding	Brd4	IDA		Mouse	PMID:16109376
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	BRD4	IMP		Human	PMID:21555454
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	BRD4	IMP		Human	PMID:10938129
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	BRD4	IDA		Human	PMID:19103749
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	BRD4	IDA		Human	PMID:23086925
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	BRD4	IDA		Human	PMID:23317504
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	BRD4	IDA		Human	PMID:24360279
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	BRD4	IMP		Human	PMID:18039861
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	BRD4	IDA		Human	PMID:19103749
Biological Process	GO:0046777	protein autophosphorylation	Brd4	IDA		Mouse	PMID:22509028
Biological Process	GO:0006468	protein phosphorylation	Brd4	IPI	UniProtKB:O60563	Mouse	PMID:16109376
Biological Process	GO:0006468	protein phosphorylation	Brd4	IPI	UniProtKB:P50750	Mouse	PMID:16109376
Biological Process	GO:0050727	regulation of inflammatory response	BRD4	IDA		Human	PMID:19103749
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	BRD4	IMP		Human	PMID:18039861
Biological Process	GO:0002574	thrombocyte differentiation	brd4	IMP	ZFIN:ZDB-MRPHLNO-141013-7	Zfish	PMID:25010335

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern