Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRK1
  • Mouse genes Brk1
  • Rat genes Brk1
  • Zfish genes brk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	BRK1	IDA		Human	PMID:18560548
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9Y6W5	Human	PMID:18560548
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:B1Q236,UniProtKB:Q7L576,UniProtKB:Q92558,UniProtKB:Q9NYB9,UniProtKB:Q9Y2A7	Human	PMID:24439377
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q96EV8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9GZM8	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O75506	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9GZM8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9Y605	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O00746	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O14744	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O14874-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O15534	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O43257	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O60220	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O95238	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:O95563	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P01023	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P09172	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P09936	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P19404	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P26641	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P40227	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P41219	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P41231	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P45880	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P51608	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P61086	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:P68363-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q0VDD7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q15012	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q3KNT9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q5T6S3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q5VTR2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q7L3B6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q86TI2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q86V28	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8IY31-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8N0U8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8N488	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8N7X4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8TAB7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8TAS3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8TCT7-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8TCV5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q96FW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q99700-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q99996-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9BRT8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9BVL2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9GZM8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9H5F2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BRK1	IPI	UniProtKB:Q9Y605	Human	PMID:32814053
Molecular Function	GO:0044877	protein-containing complex binding	BRK1	IPI	GO:0031209	Human	PMID:18560548
Molecular Function	GO:0031267	small GTPase binding	BRK1	IDA		Human	PMID:21107423
Cellular Component	GO:0070062	extracellular exosome	BRK1	HDA		Human	PMID:20458337
Cellular Component	GO:0030027	lamellipodium	Brk1	IDA		Mouse	MGI:MGI:5545995|PMID:18560548
Cellular Component	GO:0031209	SCAR complex	BRK1	IDA		Human	PMID:18560548
Cellular Component	GO:0031209	SCAR complex	BRK1	IDA		Human	PMID:21107423
Biological Process	GO:0030036	actin cytoskeleton organization	Brk1	IMP	MGI:MGI:3872157	Mouse	PMID:20861187
Biological Process	GO:0048870	cell motility	Brk1	IMP		Mouse	PMID:20861187
Biological Process	GO:0048144	fibroblast proliferation	Brk1	IMP		Mouse	PMID:20861187
Biological Process	GO:0007507	heart development	brk1	IMP	ZFIN:ZDB-CRISPR-201116-2	Zfish	PMID:32368696
Biological Process	GO:0001701	in utero embryonic development	Brk1	IMP	MGI:MGI:3872157	Mouse	PMID:20861187
Biological Process	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	BRK1	IDA		Human	PMID:21107423
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Brk1	IMP		Mouse	PMID:20861187
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	BRK1	IMP		Human	PMID:18560548
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	BRK1	IDA		Human	PMID:21107423
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	BRK1	IMP		Human	PMID:18560548
Biological Process	GO:0016601	Rac protein signal transduction	BRK1	IDA		Human	PMID:21107423

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern