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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Brk1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brk1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042802identical protein bindingBRK1IDAHumanPMID:18560548
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9Y6W5HumanPMID:18560548
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:B1Q236,UniProtKB:Q7L576,UniProtKB:Q92558,UniProtKB:Q9NYB9,UniProtKB:Q9Y2A7HumanPMID:24439377
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q96EV8HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9GZM8HumanPMID:31413325
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O75506HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9GZM8HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9Y605HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:D3DTS7HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:G5E9A7HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O00746HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O14744HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O14874-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O14901HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O15534HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O43257HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O60220HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O60260-5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O60333-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O95238HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:O95563HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P01023HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P09172HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P09936HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P14136HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P19404HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P26641HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P28799HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P37840HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P40227HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P41219HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P41231HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P42858HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P45880HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P46379-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P50570-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P51608HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P61086HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:P68363-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q0VDD7HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q14203-5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q15012HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q3KNT9HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q5T6S3HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q5VTR2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q7L3B6HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q7Z699HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q86TI2-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q86V28HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8IY31-3HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8N0U8HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8N488HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8N7X4HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8TAB7HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8TAS3HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8TCT7-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8TCV5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q8WXH2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q96FW1HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q99700-5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q99996-3HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9BRT8HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9BVL2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9GZM8HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9H5F2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9Y3C5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingBRK1IPIUniProtKB:Q9Y605HumanPMID:32814053
Molecular FunctionGO:0044877protein-containing complex bindingBRK1IPIGO:0031209HumanPMID:18560548
Molecular FunctionGO:0031267small GTPase bindingBRK1IDAHumanPMID:21107423
Cellular ComponentGO:0070062extracellular exosomeBRK1HDAHumanPMID:20458337
Cellular ComponentGO:0030027lamellipodiumBrk1IDAMouseMGI:MGI:5545995|PMID:18560548
Cellular ComponentGO:0031209SCAR complexBRK1IDAHumanPMID:18560548
Cellular ComponentGO:0031209SCAR complexBRK1IDAHumanPMID:21107423
Biological ProcessGO:0030036actin cytoskeleton organizationBrk1IMPMGI:MGI:3872157MousePMID:20861187
Biological ProcessGO:0048870cell motilityBrk1IMPMousePMID:20861187
Biological ProcessGO:0048144fibroblast proliferationBrk1IMPMousePMID:20861187
Biological ProcessGO:0007507heart developmentbrk1IMPZFIN:ZDB-CRISPR-201116-2ZfishPMID:32368696
Biological ProcessGO:0001701in utero embryonic developmentBrk1IMPMGI:MGI:3872157MousePMID:20861187
Biological ProcessGO:2000601positive regulation of Arp2/3 complex-mediated actin nucleationBRK1IDAHumanPMID:21107423
Biological ProcessGO:0048146positive regulation of fibroblast proliferationBrk1IMPMousePMID:20861187
Biological ProcessGO:0010592positive regulation of lamellipodium assemblyBRK1IMPHumanPMID:18560548
Biological ProcessGO:0010592positive regulation of lamellipodium assemblyBRK1IDAHumanPMID:21107423
Biological ProcessGO:0031334positive regulation of protein-containing complex assemblyBRK1IMPHumanPMID:18560548
Biological ProcessGO:0016601Rac protein signal transductionBRK1IDAHumanPMID:21107423

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory