Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRSK1
  • Mouse genes Brsk1
  • Rat genes Brsk1
  • Zfish genes brsk1a,brsk1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brsk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043015	gamma-tubulin binding	Brsk1	IDA		Mouse	MGI:MGI:4411964|PMID:19648910
Molecular Function	GO:0000287	magnesium ion binding	BRSK1	IDA		Human	PMID:14976552
Molecular Function	GO:0140678	molecular function inhibitor activity	Brsk1	EXP		Mouse	MGI:MGI:6880801|PMID:27251228
Molecular Function	GO:0005515	protein binding	Brsk1	IPI	PR:P47810	Mouse	PMID:20026642
Molecular Function	GO:0005515	protein binding	Brsk1	IPI	PR:Q69Z98	Mouse	PMID:20026642
Molecular Function	GO:0005515	protein binding	Brsk1	IPI	UniProtKB:Q9JIR4	Rat	PMID:16630837|RGD:8553864
Molecular Function	GO:0019901	protein kinase binding	Brsk1	IPI	UniProtKB:Q9WTK7	Mouse	MGI:MGI:4462353|PMID:17482548
Molecular Function	GO:0004674	protein serine/threonine kinase activity	BRSK1	IDA		Human	PMID:15150265
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Brsk1	IDA		Mouse	MGI:MGI:4411964|PMID:19648910
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Brsk1	IDA		Rat	PMID:16630837|RGD:8553864
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Brsk1	IMP		Rat	PMID:25788287|RGD:13514090
Molecular Function	GO:0050321	tau-protein kinase activity	BRSK1	IDA		Human	PMID:21985311
Molecular Function	GO:0050321	tau-protein kinase activity	Brsk1	IDA		Mouse	MGI:MGI:3528781|PMID:15705853
Cellular Component	GO:0030054	cell junction	BRSK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	Brsk1	IDA		Mouse	MGI:MGI:4411964|PMID:19648910
Cellular Component	GO:0005737	cytoplasm	BRSK1	IDA		Human	PMID:15150265
Cellular Component	GO:0150034	distal axon	Brsk1	IMP		Rat	PMID:25788287|RGD:13514090
Cellular Component	GO:0005654	nucleoplasm	BRSK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BRSK1	IDA		Human	PMID:15150265
Cellular Component	GO:0008021	synaptic vesicle	Brsk1	IDA		Rat	PMID:16630837|RGD:8553864
Biological Process	GO:0008306	associative learning	Brsk1	IMP		Mouse	MGI:MGI:5707546|PMID:26444684
Biological Process	GO:0007409	axonogenesis	Brsk1	IMP		Mouse	MGI:MGI:4462353|PMID:17482548
Biological Process	GO:0051298	centrosome duplication	Brsk1	IMP		Mouse	MGI:MGI:4411964|PMID:19648910
Biological Process	GO:0006974	DNA damage response	BRSK1	IDA		Human	PMID:15150265
Biological Process	GO:0030010	establishment of cell polarity	Brsk1	IMP		Mouse	MGI:MGI:4462353|PMID:17482548
Biological Process	GO:0030010	establishment of cell polarity	Brsk1	IGI	MGI:MGI:1923020	Mouse	PMID:15705853
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	BRSK1	IDA		Human	PMID:15150265
Biological Process	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity	Brsk1	IGI	UniProtKB:Q69Z98	Mouse	MGI:MGI:6148529|PMID:18268107
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	BRSK1	IDA		Human	PMID:15150265
Biological Process	GO:0030182	neuron differentiation	Brsk1	IGI	MGI:MGI:1923020	Mouse	PMID:15705853
Biological Process	GO:0048812	neuron projection morphogenesis	Brsk1	IGI	MGI:MGI:103075	Mouse	PMID:20026642
Biological Process	GO:0048812	neuron projection morphogenesis	Brsk1	IGI	MGI:MGI:1923020	Mouse	PMID:20026642
Biological Process	GO:0007269	neurotransmitter secretion	Brsk1	IMP		Rat	PMID:16630837|RGD:8553864
Biological Process	GO:0018105	peptidyl-serine phosphorylation	BRSK1	IDA		Human	PMID:15150265
Biological Process	GO:0006468	protein phosphorylation	BRSK1	IDA		Human	PMID:15150265
Biological Process	GO:0050770	regulation of axonogenesis	Brsk1	IGI	UniProtKB:Q69Z98	Mouse	MGI:MGI:6148529|PMID:18268107
Biological Process	GO:0010975	regulation of neuron projection development	Brsk1	IGI	UniProtKB:Q69Z98	Mouse	MGI:MGI:6148529|PMID:18268107
Biological Process	GO:0048167	regulation of synaptic plasticity	Brsk1	IMP		Mouse	MGI:MGI:5707546|PMID:26444684
Biological Process	GO:0009411	response to UV	BRSK1	IDA		Human	PMID:15150265
Biological Process	GO:0099504	synaptic vesicle cycle	Brsk1	IMP		Mouse	MGI:MGI:5707546|PMID:26444684

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern