Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRSK2
  • Mouse genes Brsk2
  • Rat genes Brsk2
  • Zfish genes brsk2a,brsk2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brsk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	BRSK2	IDA		Human	PMID:14976552
Molecular Function	GO:0051117	ATPase binding	BRSK2	IDA		Human	PMID:23907667
Molecular Function	GO:0000287	magnesium ion binding	BRSK2	IDA		Human	PMID:14976552
Molecular Function	GO:0005515	protein binding	BRSK2	IPI	UniProtKB:Q92905	Human	PMID:22609399
Molecular Function	GO:0005515	protein binding	Brsk2	IPI	PR:P47810	Mouse	PMID:20026642
Molecular Function	GO:0005515	protein binding	Brsk2	IPI	PR:Q5RJI5	Mouse	PMID:20026642
Molecular Function	GO:0019901	protein kinase binding	Brsk2	IPI	UniProtKB:Q9WTK7	Mouse	MGI:MGI:4462353|PMID:17482548
Molecular Function	GO:0004674	protein serine/threonine kinase activity	BRSK2	IDA		Human	PMID:14976552
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Brsk2	IDA		Mouse	MGI:MGI:3528781|PMID:15705853
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Brsk2	IDA		Mouse	PMID:20026642
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Brsk2	IMP		Rat	PMID:25788287|RGD:13514090
Molecular Function	GO:0050321	tau-protein kinase activity	BRSK2	IDA		Human	PMID:21985311
Molecular Function	GO:0050321	tau-protein kinase activity	Brsk2	IDA		Mouse	MGI:MGI:3528781|PMID:15705853
Cellular Component	GO:0005813	centrosome	BRSK2	IDA		Human	PMID:23029325
Cellular Component	GO:0005737	cytoplasm	BRSK2	IDA		Human	PMID:22713462
Cellular Component	GO:0005737	cytoplasm	BRSK2	IDA		Human	PMID:23907667
Cellular Component	GO:0150034	distal axon	Brsk2	IMP		Rat	PMID:25788287|RGD:13514090
Cellular Component	GO:0005783	endoplasmic reticulum	BRSK2	IDA		Human	PMID:23907667
Biological Process	GO:0031532	actin cytoskeleton reorganization	BRSK2	IMP		Human	PMID:22669945
Biological Process	GO:0007409	axonogenesis	Brsk2	IMP		Mouse	MGI:MGI:4462353|PMID:17482548
Biological Process	GO:0036503	ERAD pathway	BRSK2	IMP		Human	PMID:23907667
Biological Process	GO:0030010	establishment of cell polarity	Brsk2	IMP		Mouse	MGI:MGI:4462353|PMID:17482548
Biological Process	GO:0030010	establishment of cell polarity	Brsk2	IGI	MGI:MGI:2685946	Mouse	PMID:15705853
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	BRSK2	IMP		Human	PMID:23029325
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	BRSK2	IMP		Human	PMID:22713462
Biological Process	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity	Brsk2	IGI	UniProtKB:Q5RJI5	Mouse	MGI:MGI:6148529|PMID:18268107
Biological Process	GO:0030182	neuron differentiation	Brsk2	IGI	MGI:MGI:2685946	Mouse	PMID:15705853
Biological Process	GO:0048812	neuron projection morphogenesis	Brsk2	IGI	MGI:MGI:103075	Mouse	PMID:20026642
Biological Process	GO:0048812	neuron projection morphogenesis	Brsk2	IGI	MGI:MGI:2685946	Mouse	PMID:20026642
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Brsk2	IDA		Mouse	PMID:20026642
Biological Process	GO:0006468	protein phosphorylation	BRSK2	IDA		Human	PMID:14976552
Biological Process	GO:0006468	protein phosphorylation	Brsk2	IDA		Mouse	MGI:MGI:3528781|PMID:15705853
Biological Process	GO:0050770	regulation of axonogenesis	Brsk2	IGI	UniProtKB:Q5RJI5	Mouse	MGI:MGI:6148529|PMID:18268107
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	BRSK2	IMP		Human	PMID:22669945
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Brsk2	IMP		Mouse	MGI:MGI:5448801|PMID:22798068
Biological Process	GO:0010975	regulation of neuron projection development	Brsk2	IGI	UniProtKB:Q5RJI5	Mouse	MGI:MGI:6148529|PMID:18268107

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern