Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BTC
  • Mouse genes Btc
  • Rat genes Btc
  • Zfish genes btc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Btc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Btc	IDA		Rat	PMID:11564606|RGD:2324625
Molecular Function	GO:0008083	growth factor activity	Btc	IDA		Rat	PMID:11564606|RGD:2324625
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:P26447	Human	PMID:19740107
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:Q96IJ6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:O43765	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:Q96IJ6	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:Q5T749	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BTC	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0048018	receptor ligand activity	BTC	IDA		Human	PMID:12399441
Molecular Function	GO:0048018	receptor ligand activity	BTC	IDA		Human	PMID:9168114
Molecular Function	GO:0048018	receptor ligand activity	Btc	IGI	MGI:MGI:95294	Mouse	PMID:18656477
Molecular Function	GO:0048018	receptor ligand activity	Btc	IDA		Mouse	PMID:8456283
Molecular Function	GO:0048018	receptor ligand activity	Btc	IDA		Mouse	PMID:21897861
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	BTC	IDA		Human	PMID:12399441
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	BTC	IDA		Human	PMID:9168114
Cellular Component	GO:0005615	extracellular space	BTC	IDA		Human	PMID:12399441
Cellular Component	GO:0005615	extracellular space	BTC	IDA		Human	PMID:9168114
Cellular Component	GO:0005615	extracellular space	Btc	IDA		Mouse	PMID:8456283
Cellular Component	GO:0005615	extracellular space	Btc	IDA		Mouse	PMID:21897861
Biological Process	GO:0006915	apoptotic process	Btc	IDA		Mouse	PMID:18656477
Biological Process	GO:0008283	cell population proliferation	Btc	IGI	MGI:MGI:88039	Mouse	PMID:18656477
Biological Process	GO:0008283	cell population proliferation	Btc	IGI	MGI:MGI:95294	Mouse	PMID:18656477
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Btc	IDA		Mouse	PMID:8456283
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Btc	IGI	MGI:MGI:95294	Mouse	PMID:18656477
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Btc	IDA		Rat	PMID:11564606|RGD:2324625
Biological Process	GO:1904019	epithelial cell apoptotic process	Btc	IDA		Mouse	PMID:18656477
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	Btc	IDA		Mouse	PMID:21897861
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	BTC	IDA		Human	PMID:9168114
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Btc	IDA		Mouse	PMID:18656477
Biological Process	GO:0045597	positive regulation of cell differentiation	Btc	IMP		Rat	PMID:18439098|RGD:2306975
Biological Process	GO:0008284	positive regulation of cell population proliferation	Btc	IGI	MGI:MGI:95294	Mouse	PMID:18656477
Biological Process	GO:0008284	positive regulation of cell population proliferation	Btc	IGI	MGI:MGI:88039	Mouse	PMID:18656477
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Btc	IDA		Rat	PMID:15862140|RGD:2306976
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Btc	IDA		Rat	PMID:11004502|RGD:631927
Biological Process	GO:0035810	positive regulation of urine volume	Btc	IDA		Rat	PMID:14626355|RGD:2306977

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern