Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Btk

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes BTK
- Mouse genes Btk
- Rat genes Btk
- Zfish genes btk
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Btk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	BTK	IPI	UniProtKB:Q06187	Human	PMID:11577348
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	BTK	IDA		Human	PMID:11606584
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	BTK	IGI	UniProtKB:P16885	Human	PMID:14656219
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	BTK	IDA		Human	PMID:17823121
Molecular Function	GO:0016004	phospholipase activator activity	BTK	IDA		Human	PMID:11606584
Molecular Function	GO:0043274	phospholipase binding	BTK	IPI	UniProtKB:P16885	Human	PMID:11606584
Molecular Function	GO:0043274	phospholipase binding	BTK	IPI	UniProtKB:P16885	Human	PMID:14656219
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:Q04759	Human	PMID:11788586
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:Q9Y2I7	Human	PMID:15046600
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:Q13882	Human	PMID:15539407
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:Q8WV28	Human	PMID:16969585
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:P78347	Human	PMID:19214191
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:Q99856	Human	PMID:19214191
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:P21145	Human	PMID:22366891
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:Q13444	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:P50222	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:P42768	Human	PMID:8892607
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:P78347	Human	PMID:9012831
Molecular Function	GO:0005515	protein binding	BTK	IPI	UniProtKB:O60239	Human	PMID:9571151
Molecular Function	GO:0005515	protein binding	Btk	IPI	UniProtKB:P27512	Mouse	MGI:MGI:5002402\|PMID:21441935
Molecular Function	GO:0005515	protein binding	Btk	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Btk	IPI	UniProtKB:P22366\|UniProtKB:Q80UF7	Mouse	MGI:MGI:5002402\|PMID:21441935
Molecular Function	GO:0005515	protein binding	Btk	IPI	PR:Q62431	Mouse	PMID:15456761
Molecular Function	GO:0005515	protein binding	Btk	IPI	PR:Q99LJ5	Mouse	PMID:15196959
Molecular Function	GO:0005515	protein binding	Btk	IPI	MGI:MGI:1927238	Mouse	PMID:11007757
Molecular Function	GO:0004713	protein tyrosine kinase activity	BTK	IDA		Human	PMID:34554188
Molecular Function	GO:0004713	protein tyrosine kinase activity	BTK	EXP		Human	PMID:7518558
Molecular Function	GO:0004713	protein tyrosine kinase activity	Btk	EXP		Mouse	MGI:MGI:6220262\|PMID:8630736
Molecular Function	GO:0004713	protein tyrosine kinase activity	Btk	EXP		Mouse	MGI:MGI:6217580\|PMID:7565679
Molecular Function	GO:0004713	protein tyrosine kinase activity	Btk	IDA		Mouse	MGI:MGI:7276081\|PMID:34554188
Molecular Function	GO:0004713	protein tyrosine kinase activity	Btk	IDA		Mouse	PMID:11007757
Molecular Function	GO:0004713	protein tyrosine kinase activity	Btk	IDA		Mouse	PMID:10872802
Molecular Function	GO:0004713	protein tyrosine kinase activity	Btk	IDA		Rat	PMID:12193692\|RGD:151665129
Molecular Function	GO:0004713	protein tyrosine kinase activity	Btk	IDA		Rat	PMID:7696342\|RGD:1600538
Cellular Component	GO:0005737	cytoplasm	Btk	IDA		Mouse	PMID:11007757
Cellular Component	GO:0031410	cytoplasmic vesicle	Btk	IDA		Mouse	PMID:14657254
Cellular Component	GO:0005829	cytosol	BTK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	BTK	IDA		Human	PMID:17823121
Cellular Component	GO:0005829	cytosol	Btk	IDA		Rat	PMID:14499594\|RGD:1299315
Cellular Component	GO:0045121	membrane raft	BTK	IDA		Human	PMID:15046600
Cellular Component	GO:0005634	nucleus	Btk	IDA		Mouse	PMID:11007757
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Btk	IDA		Rat	PMID:12220673\|RGD:1600535
Cellular Component	GO:0005886	plasma membrane	BTK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	BTK	IDA		Human	PMID:17823121
Biological Process	GO:0009952	anterior/posterior pattern specification	btk	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-090812-6	Zfish	PMID:19471023
Biological Process	GO:0009952	anterior/posterior pattern specification	btk	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-090812-5	Zfish	PMID:19471023
Biological Process	GO:0002344	B cell affinity maturation	Btk	IMP	MGI:MGI:1856317	Mouse	PMID:7680896
Biological Process	GO:0050853	B cell receptor signaling pathway	BTK	IDA		Human	PMID:15509800
Biological Process	GO:0048469	cell maturation	Btk	IMP	MGI:MGI:2449487	Mouse	PMID:14734712
Biological Process	GO:0098761	cellular response to interleukin-7	Btk	IMP	MGI:MGI:1856317	Mouse	PMID:7680896
Biological Process	GO:0071226	cellular response to molecule of fungal origin	Btk	IDA		Rat	PMID:10744701\|RGD:1600536
Biological Process	GO:0034614	cellular response to reactive oxygen species	Btk	IMP		Rat	PMID:10744701\|RGD:1600536
Biological Process	GO:1990959	eosinophil homeostasis	Btk	IMP		Rat	PMID:32484067\|RGD:151665124
Biological Process	GO:0002553	histamine secretion by mast cell	Btk	IMP		Rat	PMID:12220673\|RGD:1600535
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Btk	IMP	MGI:MGI:1857138	Mouse	PMID:14597404
Biological Process	GO:0035556	intracellular signal transduction	BTK	IDA		Human	PMID:11606584
Biological Process	GO:0035556	intracellular signal transduction	BTK	IGI	UniProtKB:P16885	Human	PMID:14656219
Biological Process	GO:0035556	intracellular signal transduction	BTK	IDA		Human	PMID:15509800
Biological Process	GO:0061516	monocyte proliferation	Btk	IMP		Rat	PMID:32484067\|RGD:151665124
Biological Process	GO:0050869	negative regulation of B cell activation	Btk	IMP		Rat	PMID:25545336\|RGD:151665128
Biological Process	GO:0030889	negative regulation of B cell proliferation	Btk	IMP	MGI:MGI:1856317	Mouse	PMID:7680896
Biological Process	GO:0001818	negative regulation of cytokine production	Btk	IMP		Mouse	MGI:MGI:5505742\|PMID:23544144
Biological Process	GO:0032693	negative regulation of interleukin-10 production	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:0070664	negative regulation of leukocyte proliferation	Btk	IMP		Rat	PMID:32484067\|RGD:151665124
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	btk	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-090812-5	Zfish	PMID:19471023
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	btk	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-090812-6	Zfish	PMID:19471023
Biological Process	GO:0001780	neutrophil homeostasis	Btk	IMP		Rat	PMID:32484067\|RGD:151665124
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	Btk	IMP		Rat	PMID:21521773\|RGD:151665123
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	BTK	IDA		Human	PMID:11606584
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	BTK	IGI	UniProtKB:P16885	Human	PMID:14656219
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	BTK	IDA		Human	PMID:15509800
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Btk	IDA		Mouse	PMID:10872802
Biological Process	GO:0030890	positive regulation of B cell proliferation	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:0050729	positive regulation of inflammatory response	Btk	IMP		Rat	PMID:32083858\|RGD:151665122
Biological Process	GO:0150153	positive regulation of interleukin-17A production	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	BTK	IDA		Human	PMID:34554188
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Btk	IDA		Mouse	MGI:MGI:7276081\|PMID:34554188
Biological Process	GO:0050766	positive regulation of phagocytosis	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:1901647	positive regulation of synoviocyte proliferation	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:0001812	positive regulation of type I hypersensitivity	Btk	IMP		Rat	PMID:22228807\|RGD:11040701
Biological Process	GO:0001805	positive regulation of type III hypersensitivity	Btk	IMP		Rat	PMID:22228807\|RGD:11040701
Biological Process	GO:0046777	protein autophosphorylation	Btk	IDA		Rat	PMID:7696342\|RGD:1600538
Biological Process	GO:0006468	protein phosphorylation	Btk	IDA		Mouse	PMID:12235209
Biological Process	GO:0030167	proteoglycan catabolic process	Btk	IMP		Rat	PMID:32083858\|RGD:151665122
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	btk	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-090812-6	Zfish	PMID:19471023
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	btk	IGI	ZFIN:ZDB-GENE-980526-332,ZFIN:ZDB-MRPHLNO-090812-5	Zfish	PMID:19471023
Biological Process	GO:0032496	response to lipopolysaccharide	Btk	IMP		Rat	PMID:28352114\|RGD:151665126
Biological Process	GO:0010033	response to organic substance	Btk	IMP		Rat	PMID:12220673\|RGD:1600535

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.