Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes C1QA
  • Mouse genes C1qa
  • Rat genes C1qa
  • Zfish genes c1qa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set C1qa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:P02746	Human	PMID:12960167
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:P02746	Human	PMID:21054788
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:Q9UHD9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:Q07021:PRO_0000018590	Human	PMID:28018340
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:P20138	Human	PMID:28325905
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:Q07021:PRO_0000018590	Human	PMID:34804054
Molecular Function	GO:0005515	protein binding	C1QA	IPI	UniProtKB:P02746	Human	PMID:7240
Molecular Function	GO:0005515	protein binding	C1qa	IPI	UniProtKB:Q9H461	Mouse	MGI:MGI:5431141|PMID:22682250
Cellular Component	GO:0062023	collagen-containing extracellular matrix	C1QA	HDA		Human	PMID:28675934
Cellular Component	GO:0062167	complement component C1q complex	C1QA	IPI		Human	PMID:29449492
Cellular Component	GO:0005576	extracellular region	C1QA	IDA		Human	PMID:18250442
Cellular Component	GO:0005615	extracellular space	C1qa	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0098794	postsynapse	C1qa	IGI	ComplexPortal:CPX-1180,UniProtKB:P14106,UniProtKB:Q02105	Mouse	MGI:MGI:6275119|PMID:27033548
Cellular Component	GO:0045202	synapse	C1qa	IDA		Mouse	MGI:MGI:6275119|PMID:27033548
Cellular Component	GO:0045202	synapse	C1qa	IGI	UniProtKB:P14106,UniProtKB:Q02105	Mouse	MGI:MGI:3801262|PMID:18083105
Cellular Component	GO:0045202	synapse	C1qa	IDA		Mouse	MGI:MGI:3801262|PMID:18083105
Cellular Component	GO:0045202	synapse	C1qa	IDA		Rat	PMID:18083105|RGD:13838802
Biological Process	GO:0007568	aging	C1qa	IGI	UniProtKB:P05067	Mouse	MGI:MGI:3607035|PMID:15269255
Biological Process	GO:0048143	astrocyte activation	C1qa	IGI	UniProtKB:P05067	Mouse	MGI:MGI:3607035|PMID:15269255
Biological Process	GO:0006958	complement activation, classical pathway	C1QA	IDA		Human	PMID:29449492
Biological Process	GO:0006958	complement activation, classical pathway	C1qa	IMP	MGI:MGI:2158701	Mouse	PMID:11901193
Biological Process	GO:0006958	complement activation, classical pathway	c1qa	IDA		Zfish	PMID:20615881
Biological Process	GO:0150062	complement-mediated synapse pruning	C1qa	IMP		Mouse	MGI:MGI:3801262|PMID:18083105
Biological Process	GO:0001774	microglial cell activation	C1qa	IGI	UniProtKB:P05067|UniProtKB:P05067,UniProtKB:P49768	Mouse	MGI:MGI:3607035|PMID:15269255
Biological Process	GO:0016322	neuron remodeling	C1qa	IMP		Mouse	MGI:MGI:3801262|PMID:18083105
Biological Process	GO:1901216	positive regulation of neuron death	C1qa	IGI	UniProtKB:P05067	Mouse	MGI:MGI:3607035|PMID:15269255
Biological Process	GO:0010039	response to iron ion	C1qa	IEP		Rat	PMID:18723004|RGD:2301196
Biological Process	GO:0050808	synapse organization	C1qa	IGI	ComplexPortal:CPX-1180	Mouse	MGI:MGI:6275119|PMID:27033548
Biological Process	GO:0098883	synapse pruning	C1qa	IGI	UniProtKB:P14106,UniProtKB:Q02105	Mouse	MGI:MGI:6275119|PMID:27033548
Biological Process	GO:0150064	vertebrate eye-specific patterning	C1qa	IMP		Mouse	MGI:MGI:3801262|PMID:18083105

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern