Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse C3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes C3
- Mouse genes C3
- Rat genes C3
- Zfish genes c3a.1,c3a.2,c3a.3,c3a.4,c3a.6
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set C3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding	C3	IDA		Human	PMID:15833747
Molecular Function	GO:0008289	lipid binding	C3	IDA		Rat	PMID:11305612\|RGD:5129556
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P20023	Human	PMID:11387479
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P9WIP9	Human	PMID:11705926
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P9WMK7	Human	PMID:12438350
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q9P296	Human	PMID:12540846
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q9Y279-1	Human	PMID:16530040
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q9Y279-2	Human	PMID:16530040
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q9Y279	Human	PMID:17051150
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P15529	Human	PMID:18796626
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P00751	Human	PMID:19255449
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q92496-1	Human	PMID:20042240
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P08603	Human	PMID:21317894
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P20023	Human	PMID:21527715
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P08603	Human	PMID:21979047
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q92496-1	Human	PMID:22518841
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P15529	Human	PMID:23086448
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q2FZB8	Human	PMID:26627825
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q03591:PRO_0000005896	Human	PMID:27814381
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:O95967	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:O95994	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P10228	Human	PMID:7483825
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q6F4H9	Human	PMID:7483825
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:Q9BXR6	Mouse	MGI:MGI:5905263\|PMID:23487775
Molecular Function	GO:0005515	protein binding	C3	IPI	UniProtKB:P06909	Mouse	MGI:MGI:5905263\|PMID:23487775
Molecular Function	GO:0005515	protein binding	C3	IPI	PR:P06909	Mouse	PMID:16023208
Molecular Function	GO:0005515	protein binding	C3	IPI	PR:P19070	Mouse	PMID:11728339
Molecular Function	GO:0005515	protein binding	C3	IPI	RGD:2411	Rat	PMID:12871224\|RGD:5129545
Cellular Component	GO:0072562	blood microparticle	C3	HDA		Human	PMID:22516433
Cellular Component	GO:0009986	cell surface	C3	IDA		Mouse	PMID:25284781
Cellular Component	GO:0070062	extracellular exosome	C3	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	C3	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	C3	IDA		Mouse	PMID:19411110
Cellular Component	GO:0005615	extracellular space	C3	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	C3	HDA		Human	PMID:23580065
Cellular Component	GO:0005615	extracellular space	C3	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	C3	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	C3	IDA		Mouse	PMID:18292556
Cellular Component	GO:0005615	extracellular space	C3	IDA		Rat	PMID:20712003\|RGD:5129529
Cellular Component	GO:0032991	protein-containing complex	C3	IDA		Mouse	MGI:MGI:5905263\|PMID:23487775
Biological Process	GO:0097242	amyloid-beta clearance	C3	IGI	UniProtKB:P05555	Mouse	MGI:MGI:5905548\|PMID:20199584
Biological Process	GO:0097242	amyloid-beta clearance	C3	IMP		Mouse	MGI:MGI:5319446\|PMID:22438044
Biological Process	GO:0007596	blood coagulation	C3	IMP		Rat	PMID:15956288\|RGD:1625334
Biological Process	GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	C3	IMP		Mouse	MGI:MGI:6189359\|PMID:22632727
Biological Process	GO:0071391	cellular response to estrogen stimulus	c3a.2	IDA		Zfish	PMID:18618001
Biological Process	GO:0043009	chordate embryonic development	c3a.1	IMP	ZFIN:ZDB-MRPHLNO-140818-2	Zfish	PMID:24926798
Biological Process	GO:0006956	complement activation	C3	IMP		Human	PMID:19302245
Biological Process	GO:0006956	complement activation	C3	IMP		Mouse	PMID:25284781
Biological Process	GO:0006956	complement activation	C3	IDA		Mouse	PMID:18947875
Biological Process	GO:0006956	complement activation	C3	IDA		Rat	PMID:20712003\|RGD:5129529
Biological Process	GO:0097278	complement-dependent cytotoxicity	C3	IMP		Mouse	PMID:25284781
Biological Process	GO:0150062	complement-mediated synapse pruning	C3	IMP		Mouse	MGI:MGI:3801262\|PMID:18083105
Biological Process	GO:0042742	defense response to bacterium	c3a.3	IDA		Zfish	PMID:29572872
Biological Process	GO:0006955	immune response	c3a.3	IDA		Zfish	PMID:29572872
Biological Process	GO:0016322	neuron remodeling	C3	IMP		Mouse	MGI:MGI:3801262\|PMID:18083105
Biological Process	GO:0035846	oviduct epithelium development	C3	IGI	MGI:MGI:2137383	Mouse	PMID:31604923
Biological Process	GO:0001970	positive regulation of activation of membrane attack complex	C3	IMP		Mouse	MGI:MGI:4430818\|PMID:15611275
Biological Process	GO:0045766	positive regulation of angiogenesis	C3	IMP		Mouse	MGI:MGI:3617287\|PMID:16452172
Biological Process	GO:0045766	positive regulation of angiogenesis	C3	IMP		Mouse	MGI:MGI:4430818\|PMID:15611275
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance	C3	IMP		Human	PMID:19302245
Biological Process	GO:0048639	positive regulation of developmental growth	C3	IDA		Rat	PMID:20712003\|RGD:5129529
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	C3	IDA		Rat	PMID:18178156\|RGD:5129534
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	C3	IDA		Human	PMID:15833747
Biological Process	GO:0010828	positive regulation of glucose transmembrane transport	C3	IDA		Human	PMID:15833747
Biological Process	GO:0010828	positive regulation of glucose transmembrane transport	C3	IDA		Human	PMID:9059512
Biological Process	GO:0010884	positive regulation of lipid storage	C3	IDA		Human	PMID:9555951
Biological Process	GO:1902624	positive regulation of neutrophil migration	c3a.1	IMP	ZFIN:ZDB-GENO-220510-1	Zfish	PMID:32973200
Biological Process	GO:0050766	positive regulation of phagocytosis	C3	IMP	MGI:MGI:1861799	Mouse	PMID:11901193
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	C3	IMP		Mouse	MGI:MGI:6189359\|PMID:22632727
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	C3	IMP		Mouse	MGI:MGI:5319446\|PMID:22438044
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	C3	IGI	UniProtKB:P05555	Mouse	MGI:MGI:5905548\|PMID:20199584
Biological Process	GO:0001934	positive regulation of protein phosphorylation	C3	IDA		Human	PMID:15833747
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	C3	IMP		Mouse	MGI:MGI:5319446\|PMID:22438044
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	C3	IGI	UniProtKB:P05555	Mouse	MGI:MGI:5905548\|PMID:20199584
Biological Process	GO:0001798	positive regulation of type IIa hypersensitivity	C3	IMP	MGI:MGI:1861799	Mouse	PMID:11901193
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	C3	IDA		Human	PMID:16452172
Biological Process	GO:0010866	regulation of triglyceride biosynthetic process	C3	IDA		Human	PMID:10432298
Biological Process	GO:0009617	response to bacterium	C3	IEP		Mouse	PMID:23012479
Biological Process	GO:0032355	response to estradiol	C3	IEP		Rat	PMID:12370124\|RGD:5129549
Biological Process	GO:0043627	response to estrogen	C3	IEP		Rat	PMID:11846090\|RGD:5129551
Biological Process	GO:0051384	response to glucocorticoid	C3	IEP		Rat	PMID:11566438\|RGD:5129552
Biological Process	GO:0032026	response to magnesium ion	C3	IEP		Rat	PMID:12759143\|RGD:5129546
Biological Process	GO:0032570	response to progesterone	C3	IEP		Rat	PMID:11566438\|RGD:5129552
Biological Process	GO:0009410	response to xenobiotic stimulus	C3	IEP		Rat	PMID:29695418\|RGD:19165124
Biological Process	GO:0060041	retina development in camera-type eye	C3	IGI		Mouse	PMID:28057640
Biological Process	GO:0002507	tolerance induction	C3	IEP		Rat	PMID:16555329\|RGD:5129541
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	C3	IGI		Mouse	PMID:28057640
Biological Process	GO:0150064	vertebrate eye-specific patterning	C3	IMP		Mouse	MGI:MGI:3801262\|PMID:18083105

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/15/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.