Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes C4A,C4B,C4B_2
  • Mouse genes C4b
  • Rat genes C4a,C4b
  • Zfish genes c4,c4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set C4b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	C4B	IDA		Human	PMID:2395880
Molecular Function	GO:0001848	complement binding	C4B	IDA		Human	PMID:2395880
Molecular Function	GO:0001849	complement component C1q complex binding	C4A	IDA		Human	PMID:2395880
Cellular Component	GO:0030424	axon	C4A	IDA		Human	PMID:26814963
Cellular Component	GO:0072562	blood microparticle	C4A	HDA		Human	PMID:22516433
Cellular Component	GO:0072562	blood microparticle	C4B	HDA		Human	PMID:22516433
Cellular Component	GO:0030425	dendrite	C4A	IDA		Human	PMID:26814963
Cellular Component	GO:0070062	extracellular exosome	C4A	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	C4B	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	C4a	IDA		Rat	PMID:8805663|RGD:8554675
Cellular Component	GO:0005615	extracellular space	C4A	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	C4A	IDA		Human	PMID:25645918
Cellular Component	GO:0005615	extracellular space	C4B	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	C4B	IDA		Human	PMID:2395880
Cellular Component	GO:0005615	extracellular space	C4b	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	C4b	IDA		Mouse	PMID:3023818
Cellular Component	GO:0005615	extracellular space	C4b	IDA		Rat	PMID:15634920|RGD:1599521
Cellular Component	GO:0005615	extracellular space	C4a	IDA		Rat	PMID:15634920|RGD:1599521
Cellular Component	GO:0043025	neuronal cell body	C4A	IDA		Human	PMID:26814963
Cellular Component	GO:0106139	symbiont cell surface	C4B	IDA		Human	PMID:22333221
Cellular Component	GO:0045202	synapse	C4A	IDA		Human	PMID:26814963
Biological Process	GO:0006956	complement activation	C4A	IGI	UniProtKB:P0C0L5	Human	PMID:19302245
Biological Process	GO:0006956	complement activation	C4B	IGI	UniProtKB:P0C0L4	Human	PMID:19302245
Biological Process	GO:0006956	complement activation	C4b	IMP	MGI:MGI:1889070	Mouse	PMID:12421924
Biological Process	GO:0032490	detection of molecule of bacterial origin	C4B	IDA		Human	PMID:22333221
Biological Process	GO:0016064	immunoglobulin mediated immune response	C4b	IMP	MGI:MGI:1889070	Mouse	PMID:12421924
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance	C4A	IGI	UniProtKB:P0C0L5	Human	PMID:19302245
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance	C4B	IGI	UniProtKB:P0C0L4	Human	PMID:19302245

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern