Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes C5AR1
  • Mouse genes C5ar1
  • Rat genes C5ar1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set C5ar1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001856	complement component C5a binding	C5ar1	IDA		Rat	PMID:15292245|RGD:2303020
Molecular Function	GO:0004878	complement component C5a receptor activity	C5AR1	IDA		Human	PMID:10571060
Molecular Function	GO:0004878	complement component C5a receptor activity	C5AR1	IDA		Human	PMID:22496247
Molecular Function	GO:0004878	complement component C5a receptor activity	C5ar1	IDA		Mouse	PMID:1401897
Molecular Function	GO:0004878	complement component C5a receptor activity	C5ar1	IDA		Rat	PMID:15292245|RGD:2303020
Molecular Function	GO:0004878	complement component C5a receptor activity	C5ar1	IDA		Rat	PMID:9464523|RGD:727626
Molecular Function	GO:0004930	G protein-coupled receptor activity	C5AR1	IPI	UniProtKB:P30678	Human	PMID:10571060
Molecular Function	GO:0004930	G protein-coupled receptor activity	C5AR1	IPI	UniProtKB:P30679	Human	PMID:10571060
Molecular Function	GO:0004930	G protein-coupled receptor activity	C5AR1	IPI	UniProtKB:Q9TU29	Human	PMID:10571060
Cellular Component	GO:0045177	apical part of cell	C5AR1	IDA		Human	PMID:22496247
Cellular Component	GO:0016323	basolateral plasma membrane	C5AR1	IDA		Human	PMID:22960554
Cellular Component	GO:0009986	cell surface	C5ar1	IDA		Rat	PMID:9464523|RGD:727626
Cellular Component	GO:0005886	plasma membrane	C5ar1	IDA		Rat	PMID:15292245|RGD:2303020
Biological Process	GO:0097242	amyloid-beta clearance	C5ar1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4354701|PMID:19561098
Biological Process	GO:0031100	animal organ regeneration	C5ar1	IEP		Rat	PMID:15322206|RGD:1600596
Biological Process	GO:0006915	apoptotic process	C5ar1	IMP		Rat	PMID:18648551|RGD:5130170
Biological Process	GO:0048143	astrocyte activation	C5ar1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4354701|PMID:19561098
Biological Process	GO:0021534	cell proliferation in hindbrain	C5ar1	IMP		Rat	PMID:18635264|RGD:5129699
Biological Process	GO:0050890	cognition	C5ar1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4354701|PMID:19561098
Biological Process	GO:0038178	complement component C5a signaling pathway	C5AR1	IDA		Human	PMID:10571060
Biological Process	GO:0050830	defense response to Gram-positive bacterium	C5ar1	IMP		Mouse	PMID:17114491
Biological Process	GO:0006954	inflammatory response	C5ar1	IEP		Rat	PMID:11823527|RGD:70320
Biological Process	GO:0001774	microglial cell activation	C5ar1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4354701|PMID:19561098
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	C5AR1	IDA		Human	PMID:22496247
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	C5ar1	IDA		Rat	PMID:15292245|RGD:2303020
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	C5ar1	IMP		Rat	PMID:15292245|RGD:2303020
Biological Process	GO:0030593	neutrophil chemotaxis	C5ar1	IMP	MGI:MGI:1934246	Mouse	PMID:17114491
Biological Process	GO:0045766	positive regulation of angiogenesis	C5ar1	IMP		Mouse	MGI:MGI:3617287|PMID:16452172
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	C5ar1	IDA		Rat	PMID:15292245|RGD:2303020
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	C5ar1	IDA		Rat	PMID:9272704|RGD:70679
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	C5ar1	IDA		Rat	PMID:9464523|RGD:727626
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	C5AR1	IDA		Human	PMID:22496247
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	C5AR1	IDA		Human	PMID:22496247
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	C5ar1	IMP		Mouse	MGI:MGI:3617287|PMID:16452172
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	C5ar1	IMP		Mouse	MGI:MGI:3617287|PMID:16452172
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	C5ar1	IMP		Mouse	MGI:MGI:3617287|PMID:16452172
Biological Process	GO:0099172	presynapse organization	C5ar1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4354701|PMID:19561098
Biological Process	GO:1902947	regulation of tau-protein kinase activity	C5ar1	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4354701|PMID:19561098
Biological Process	GO:0032496	response to lipopolysaccharide	C5ar1	IEP		Rat	PMID:15322206|RGD:1600596
Biological Process	GO:0032494	response to peptidoglycan	C5ar1	IMP	MGI:MGI:1934246	Mouse	PMID:17114491

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern