Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse C9orf72

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes C9orf72
- Mouse genes C9orf72
- Rat genes RGD1359108
- Zfish genes zgc:100846
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set C9orf72

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	C9orf72	IDA		Human	PMID:27103069
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	C9orf72	IDA		Human	PMID:27617292
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:P49770	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:P09651	Human	PMID:24549040
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:P22626	Human	PMID:24549040
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:O43186	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q13287	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q53XC2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q9BPX4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:P11142	Human	PMID:27103069
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q8TEV9	Human	PMID:27103069
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q8TEV9	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q8TEV9	Human	PMID:27559131
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q8TEV9	Human	PMID:28195531
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:O75817	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:P38432	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:P49770	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q17R54	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q86UV6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q8TEV9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q9H8Y1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q9NP66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q8TEV9,UniProtKB:Q9HAD4	Human	PMID:32303654
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q3UMB5	Mouse	MGI:MGI:5811684\|PMID:27875531
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q9QZM0	Mouse	MGI:MGI:5553382\|PMID:24549040
Molecular Function	GO:0005515	protein binding	C9orf72	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:6451238\|PMID:31651360
Molecular Function	GO:0031267	small GTPase binding	C9orf72	IDA		Human	PMID:24549040
Molecular Function	GO:0031267	small GTPase binding	C9orf72	IPI	UniProtKB:P51150\|UniProtKB:P62821	Mouse	MGI:MGI:5553382\|PMID:24549040
Cellular Component	GO:0005776	autophagosome	C9orf72	IDA		Human	PMID:24549040
Cellular Component	GO:0044295	axonal growth cone	C9orf72	IDA		Human	PMID:27723745
Cellular Component	GO:0005737	cytoplasm	C9orf72	IDA		Human	PMID:27037575
Cellular Component	GO:0005737	cytoplasm	C9orf72	IDA		Human	PMID:27193190
Cellular Component	GO:0005737	cytoplasm	C9orf72	IDA		Mouse	MGI:MGI:5553382\|PMID:24549040
Cellular Component	GO:0005737	cytoplasm	C9orf72	IDA		Mouse	MGI:MGI:6094680\|PMID:26408000
Cellular Component	GO:0005737	cytoplasm	C9orf72	IDA		Mouse	MGI:MGI:5810480\|PMID:27617292
Cellular Component	GO:0005737	cytoplasm	C9orf72	IDA		Mouse	MGI:MGI:6103721\|PMID:27476503
Cellular Component	GO:0010494	cytoplasmic stress granule	C9orf72	IDA		Human	PMID:27037575
Cellular Component	GO:0005829	cytosol	C9orf72	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005768	endosome	C9orf72	IDA		Human	PMID:24549040
Cellular Component	GO:0005615	extracellular space	C9orf72	IDA		Human	PMID:24549040
Cellular Component	GO:0005615	extracellular space	C9orf72	IDA		Mouse	MGI:MGI:5553382\|PMID:24549040
Cellular Component	GO:0090543	Flemming body	C9orf72	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	C9orf72	IDA		Human	PMID:27103069
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	C9orf72	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	C9orf72	IDA		Human	PMID:24549040
Cellular Component	GO:0005764	lysosome	C9orf72	IDA		Human	PMID:27559131
Cellular Component	GO:0044304	main axon	C9orf72	IDA		Human	PMID:27723745
Cellular Component	GO:0043005	neuron projection	C9orf72	IDA		Mouse	MGI:MGI:6094680\|PMID:26408000
Cellular Component	GO:0005634	nucleus	C9orf72	IDA		Human	PMID:24549040
Cellular Component	GO:0005634	nucleus	C9orf72	IDA		Human	PMID:27037575
Cellular Component	GO:0005634	nucleus	C9orf72	IDA		Mouse	MGI:MGI:6103721\|PMID:27476503
Cellular Component	GO:0005634	nucleus	C9orf72	IDA		Mouse	MGI:MGI:5553382\|PMID:24549040
Cellular Component	GO:0005634	nucleus	C9orf72	IDA		Mouse	MGI:MGI:6094680\|PMID:26408000
Cellular Component	GO:0000932	P-body	C9orf72	IDA		Human	PMID:27037575
Cellular Component	GO:0043204	perikaryon	C9orf72	IDA		Mouse	MGI:MGI:6094680\|PMID:26408000
Cellular Component	GO:0098794	postsynapse	C9orf72	IDA		Mouse	MGI:MGI:6451238\|PMID:31651360
Cellular Component	GO:0098793	presynapse	C9orf72	IDA		Mouse	MGI:MGI:6451238\|PMID:31651360
Biological Process	GO:0006914	autophagy	C9orf72	IMP		Human	PMID:24549040
Biological Process	GO:0061564	axon development	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-1	Zfish	PMID:23720273
Biological Process	GO:0061564	axon development	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-2	Zfish	PMID:23720273
Biological Process	GO:0048675	axon extension	C9orf72	IMP		Human	PMID:27723745
Biological Process	GO:0048675	axon extension	C9orf72	IMP		Mouse	MGI:MGI:5818605\|PMID:27723745
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-180910-1	Zfish	PMID:29522758
Biological Process	GO:0006897	endocytosis	C9orf72	IMP		Human	PMID:24549040
Biological Process	GO:1902774	late endosome to lysosome transport	C9orf72	IMP		Mouse	MGI:MGI:5779453\|PMID:26989253
Biological Process	GO:1904425	negative regulation of GTP binding	C9orf72	IMP		Mouse	MGI:MGI:5818605\|PMID:27723745
Biological Process	GO:0001933	negative regulation of protein phosphorylation	C9orf72	IMP		Human	PMID:27723745
Biological Process	GO:0001933	negative regulation of protein phosphorylation	C9orf72	IMP		Mouse	MGI:MGI:5818605\|PMID:27723745
Biological Process	GO:0043547	positive regulation of GTPase activity	C9orf72	IMP		Human	PMID:32303654
Biological Process	GO:0016239	positive regulation of macroautophagy	C9orf72	IGI	UniProtKB:Q96DA2	Human	PMID:27103069
Biological Process	GO:0016239	positive regulation of macroautophagy	C9orf72	IMP		Human	PMID:27103069
Biological Process	GO:0016239	positive regulation of macroautophagy	C9orf72	IMP		Human	PMID:27334615
Biological Process	GO:0110053	regulation of actin filament organization	C9orf72	IMP		Human	PMID:27723745
Biological Process	GO:0110053	regulation of actin filament organization	C9orf72	IMP		Mouse	MGI:MGI:5818605\|PMID:27723745
Biological Process	GO:2000785	regulation of autophagosome assembly	C9orf72	IMP		Human	PMID:27334615
Biological Process	GO:0010506	regulation of autophagy	C9orf72	IMP		Human	PMID:27103069
Biological Process	GO:0010506	regulation of autophagy	C9orf72	IMP		Mouse	MGI:MGI:5811684\|PMID:27875531
Biological Process	GO:0010506	regulation of autophagy	C9orf72	IMP		Mouse	MGI:MGI:5810480\|PMID:27617292
Biological Process	GO:0010506	regulation of autophagy	C9orf72	IMP		Mouse	MGI:MGI:5887182\|PMID:27193190
Biological Process	GO:0032880	regulation of protein localization	C9orf72	IMP		Mouse	MGI:MGI:6451238\|PMID:31651360
Biological Process	GO:1903432	regulation of TORC1 signaling	C9orf72	IMP		Human	PMID:27559131
Biological Process	GO:1903432	regulation of TORC1 signaling	C9orf72	IMP		Mouse	MGI:MGI:5811684\|PMID:27875531
Biological Process	GO:0034063	stress granule assembly	C9orf72	IMP		Human	PMID:27037575
Biological Process	GO:0036268	swimming	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-1	Zfish	PMID:23720273
Biological Process	GO:0036268	swimming	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-2	Zfish	PMID:23720273
Biological Process	GO:0036268	swimming	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-3	Zfish	PMID:23720273
Biological Process	GO:0036269	swimming behavior	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-3	Zfish	PMID:23720273
Biological Process	GO:0036269	swimming behavior	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-2	Zfish	PMID:23720273
Biological Process	GO:0036269	swimming behavior	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-1	Zfish	PMID:23720273
Biological Process	GO:0001966	thigmotaxis	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-1	Zfish	PMID:23720273
Biological Process	GO:0001966	thigmotaxis	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-3	Zfish	PMID:23720273
Biological Process	GO:0001966	thigmotaxis	zgc:100846	IMP	ZFIN:ZDB-MRPHLNO-140617-2	Zfish	PMID:23720273

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.