Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CACNA1B
  • Mouse genes Cacna1b
  • Rat genes Cacna1b
  • Zfish genes cacna1ba,cacna1bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cacna1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	CACNA1B	IMP		Human	PMID:23376566
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	Cacna1b	IDA		Mouse	PMID:23648579
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	Cacna1b	IDA		Rat	PMID:18701069|RGD:7205441
Molecular Function	GO:0005515	protein binding	CACNA1B	IPI	UniProtKB:Q86UR5	Human	PMID:11438518
Molecular Function	GO:0005515	protein binding	CACNA1B	IPI	UniProtKB:P20650	Human	PMID:15728831
Molecular Function	GO:0005515	protein binding	CACNA1B	IPI	UniProtKB:P28702	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	PR:Q8R0S4	Mouse	PMID:10328888
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	PR:Q8CC27	Mouse	PMID:10328888
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	PR:O70589	Mouse	PMID:18054859
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	PR:Q8R3Z5	Mouse	PMID:10328888
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	PR:P54285	Mouse	PMID:10328888
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	PR:Q9D8C2	Mouse	PMID:23648579
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	UniProtKB:P58917	Rat	PMID:10938268|RGD:8553988
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	RGD:2517	Rat	PMID:19755421|RGD:2316240
Molecular Function	GO:0005515	protein binding	Cacna1b	IPI	UniProtKB:P21707	Rat	PMID:9830048|RGD:8553400
Molecular Function	GO:0051721	protein phosphatase 2A binding	Cacna1b	IPI	RGD:3380	Rat	PMID:15728831|RGD:8554004
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1b	IMP		Mouse	PMID:12074836
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1b	IMP		Mouse	PMID:12827191
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1b	IMP	MGI:MGI:2180187	Mouse	PMID:11296258
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1b	IMP		Rat	PMID:10864934|RGD:1299351
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Cacna1b	EXP		Rat	PMID:7832825|RGD:13792530
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Cacna1b	IDA		Rat	PMID:7832825|RGD:13792530
Cellular Component	GO:0043679	axon terminus	Cacna1b	IDA		Rat	PMID:16736476|RGD:1582593
Cellular Component	GO:0030425	dendrite	Cacna1b	IDA		Mouse	PMID:15451373
Cellular Component	GO:0043198	dendritic shaft	Cacna1b	IDA		Rat	PMID:11353727|RGD:1580151
Cellular Component	GO:0098978	glutamatergic synapse	Cacna1b	EXP		Rat	PMID:7832825|RGD:13792530
Cellular Component	GO:0098978	glutamatergic synapse	Cacna1b	IDA		Rat	PMID:7832825|RGD:13792530
Cellular Component	GO:0016020	membrane	Cacna1b	IDA		Mouse	PMID:18054859
Cellular Component	GO:0043005	neuron projection	Cacna1b	IDA		Rat	PMID:17562281|RGD:1626314
Cellular Component	GO:0043025	neuronal cell body	Cacna1b	IDA		Mouse	PMID:15451373
Cellular Component	GO:0043025	neuronal cell body	Cacna1b	IDA		Rat	PMID:11353727|RGD:1580151
Cellular Component	GO:0005886	plasma membrane	Cacna1b	IDA		Rat	PMID:10864934|RGD:1299351
Cellular Component	GO:0005886	plasma membrane	Cacna1b	IDA		Rat	PMID:17068255|RGD:7205477
Cellular Component	GO:0048786	presynaptic active zone	Cacna1b	IDA		Mouse	PMID:25891347
Cellular Component	GO:0032991	protein-containing complex	Cacna1b	IDA		Rat	PMID:17068255|RGD:7205477
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Cacna1b	EXP		Rat	PMID:7832825|RGD:13792530
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Cacna1b	IDA		Rat	PMID:7832825|RGD:13792530
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacna1b	IDA		Mouse	PMID:10328888
Biological Process	GO:0070509	calcium ion import	Cacna1b	IMP		Rat	PMID:15548655|RGD:7175534
Biological Process	GO:0070588	calcium ion transmembrane transport	Cacna1b	IMP		Mouse	PMID:12074836
Biological Process	GO:0006816	calcium ion transport	Cacna1b	IMP		Mouse	PMID:12827191
Biological Process	GO:0006816	calcium ion transport	Cacna1b	IMP	MGI:MGI:2180187	Mouse	PMID:11296258
Biological Process	GO:0006816	calcium ion transport	Cacna1b	IMP		Rat	PMID:10864934|RGD:1299351
Biological Process	GO:0051649	establishment of localization in cell	Cacna1b	IMP		Mouse	PMID:12074836
Biological Process	GO:0007626	locomotory behavior	Cacna1b	IMP	MGI:MGI:2180187	Mouse	PMID:12890773
Biological Process	GO:0050804	modulation of chemical synaptic transmission	CACNA1B	IDA		Human	PMID:23376566
Biological Process	GO:0007269	neurotransmitter secretion	Cacna1b	IMP		Mouse	PMID:12827191
Biological Process	GO:0021554	optic nerve development	Cacna1b	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	Cacna1b	IMP		Rat	PMID:15987667|RGD:1626316
Biological Process	GO:0008217	regulation of blood pressure	Cacna1b	IMP	MGI:MGI:2180187	Mouse	PMID:11296258
Biological Process	GO:0051924	regulation of calcium ion transport	Cacna1b	IMP		Mouse	PMID:12074836
Biological Process	GO:0150037	regulation of calcium-dependent activation of synaptic vesicle fusion	Cacna1b	EXP		Rat	PMID:7832825|RGD:13792530
Biological Process	GO:0150037	regulation of calcium-dependent activation of synaptic vesicle fusion	Cacna1b	IDA		Rat	PMID:7832825|RGD:13792530
Biological Process	GO:0008016	regulation of heart contraction	Cacna1b	IMP	MGI:MGI:2180187	Mouse	PMID:11296258
Biological Process	GO:1904645	response to amyloid-beta	CACNA1B	IDA		Human	PMID:23376566
Biological Process	GO:0045471	response to ethanol	Cacna1b	IEP		Rat	PMID:16860782|RGD:1626311
Biological Process	GO:0014070	response to organic cyclic compound	Cacna1b	IDA		Rat	PMID:16704976|RGD:1626315
Biological Process	GO:0048265	response to pain	Cacna1b	IMP		Mouse	PMID:12074836
Biological Process	GO:0033574	response to testosterone	Cacna1b	IMP		Rat	PMID:15987667|RGD:1626316
Biological Process	GO:0019233	sensory perception of pain	Cacna1b	IMP		Rat	PMID:18433788|RGD:7205476

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern