Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cacna1d

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CACNA1D
- Mouse genes Cacna1d
- Rat genes Cacna1d
- Zfish genes cacna1da,cacna1db
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cacna1d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051393	alpha-actinin binding	CACNA1D	IPI	UniProtKB:P35609	Human	PMID:17110593
Molecular Function	GO:0030506	ankyrin binding	Cacna1d	IPI	UniProtKB:Q01484	Mouse	MGI:MGI:5427070\|PMID:21859974
Molecular Function	GO:0030506	ankyrin binding	Cacna1d	IPI	UniProtKB:Q01484	Rat	PMID:21859974\|RGD:6767284
Molecular Function	GO:0005262	calcium channel activity	CACNA1D	IMP		Human	PMID:25620733
Molecular Function	GO:0005262	calcium channel activity	CACNA1D	IMP		Human	PMID:28472301
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	CACNA1D	IDA		Human	PMID:1309651
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	Cacna1d	IDA		Mouse	PMID:12900400
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	Cacna1d	IDA		Rat	PMID:18322004\|RGD:7207845
Molecular Function	GO:0030165	PDZ domain binding	Cacna1d	IDA		Rat	PMID:17287512\|RGD:6906920
Molecular Function	GO:0005515	protein binding	CACNA1D	IPI	UniProtKB:Q9BYB0-1	Human	PMID:30058071
Molecular Function	GO:0005515	protein binding	Cacna1d	IPI	PR:O35526	Mouse	PMID:10468580
Molecular Function	GO:0005515	protein binding	Cacna1d	IPI	UniProtKB:O88871	Rat	PMID:20627102\|RGD:8554172
Molecular Function	GO:0005515	protein binding	Cacna1d	IPI	UniProtKB:Q9QX74-7	Rat	PMID:30058071\|RGD:14402445
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA1D	IDA		Human	PMID:11160515
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA1D	IDA		Human	PMID:21131953
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1d	IDA		Rat	PMID:11487617\|RGD:727563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1d	IDA		Rat	PMID:21859974\|RGD:6767284
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Cacna1d	IMP		Mouse	PMID:10929716
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Cacna1d	IDA		Mouse	PMID:10929716
Molecular Function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential	CACNA1D	IMP		Human	PMID:21131953
Molecular Function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential	Cacna1d	IMP	MGI:MGI:2180141	Mouse	PMID:15932895
Cellular Component	GO:0016324	apical plasma membrane	Cacna1d	IDA		Rat	PMID:14637163\|RGD:7205458
Cellular Component	GO:0016324	apical plasma membrane	Cacna1d	IDA		Rat	PMID:17272350\|RGD:2308883
Cellular Component	GO:0009925	basal plasma membrane	cacna1da	IDA		Zfish	PMID:15115817
Cellular Component	GO:0009986	cell surface	Cacna1d	IDA		Rat	PMID:21822937\|RGD:13782265
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	Cacna1d	IDA		Mouse	PMID:10929716
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	Cacna1d	IMP		Mouse	PMID:10929716
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	Cacna1d	IDA		Mouse	PMID:16354915
Cellular Component	GO:0005737	cytoplasm	Cacna1d	IDA		Rat	PMID:14534084\|RGD:13782368
Cellular Component	GO:0005737	cytoplasm	Cacna1d	IDA		Rat	PMID:19136044\|RGD:7205457
Cellular Component	GO:0032590	dendrite membrane	Cacna1d	IDA		Rat	PMID:16706838\|RGD:6906921
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	CACNA1D	IDA		Human	PMID:1309651
Cellular Component	GO:0005634	nucleus	Cacna1d	IDA		Rat	PMID:21378599\|RGD:6906917
Cellular Component	GO:0043204	perikaryon	Cacna1d	IDA		Rat	PMID:19136044\|RGD:7205457
Cellular Component	GO:0005886	plasma membrane	Cacna1d	IDA		Mouse	MGI:MGI:5427070\|PMID:21859974
Cellular Component	GO:0005886	plasma membrane	Cacna1d	IDA		Mouse	MGI:MGI:5430886\|PMID:18832177
Cellular Component	GO:0005886	plasma membrane	Cacna1d	IDA		Mouse	PMID:10468580
Cellular Component	GO:0048787	presynaptic active zone membrane	Cacna1d	IDA		Mouse	PMID:16354915
Cellular Component	GO:0150001	primary dendrite	Cacna1d	IDA		Rat	PMID:19136044\|RGD:7205457
Cellular Component	GO:0097470	ribbon synapse	cacna1da	IDA		Zfish	PMID:23197719
Cellular Component	GO:0042383	sarcolemma	Cacna1d	IDA		Rat	PMID:21378599\|RGD:6906917
Cellular Component	GO:0005891	voltage-gated calcium channel complex	CACNA1D	IDA		Human	PMID:11160515
Cellular Component	GO:0030018	Z disc	Cacna1d	IDA		Mouse	MGI:MGI:3771286\|PMID:17110593
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Cacna1d	IMP	MGI:MGI:2180141	Mouse	PMID:16706838
Biological Process	GO:0007568	aging	Cacna1d	IEP		Rat	PMID:12425941\|RGD:6906923
Biological Process	GO:0070509	calcium ion import	CACNA1D	IDA		Human	PMID:1309651
Biological Process	GO:0070509	calcium ion import	Cacna1d	IMP		Rat	PMID:16706838\|RGD:6906921
Biological Process	GO:0070588	calcium ion transmembrane transport	Cacna1d	IMP	MGI:MGI:2180141	Mouse	PMID:12700358
Biological Process	GO:0006816	calcium ion transport	CACNA1D	IDA		Human	PMID:11160515
Biological Process	GO:0006816	calcium ion transport	Cacna1d	IDA		Rat	PMID:21859974\|RGD:6767284
Biological Process	GO:0019722	calcium-mediated signaling	Cacna1d	IDA		Rat	PMID:7479909\|RGD:634679
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	CACNA1D	IMP		Human	PMID:21131953
Biological Process	GO:1904646	cellular response to amyloid-beta	Cacna1d	IEP		Rat	PMID:21822937\|RGD:13782265
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	cacna1da	IMP		Zfish	PMID:9491988
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	cacna1da	IMP	ZFIN:ZDB-GENO-980410-316	Zfish	PMID:15115817
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	cacna1da	IMP	ZFIN:ZDB-GENO-040525-1	Zfish	PMID:15115817
Biological Process	GO:0051649	establishment of localization in cell	Cacna1d	IMP	MGI:MGI:2180141	Mouse	PMID:12700358
Biological Process	GO:0007507	heart development	Cacna1d	IEP		Rat	PMID:21378599\|RGD:6906917
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	CACNA1D	IMP		Human	PMID:21131953
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	Cacna1d	IMP	MGI:MGI:2180141	Mouse	PMID:12700358
Biological Process	GO:0007613	memory	Cacna1d	IEP		Rat	PMID:12591156\|RGD:704382
Biological Process	GO:0030001	metal ion transport	Cacna1d	IMP		Rat	PMID:17287512\|RGD:6906920
Biological Process	GO:0050885	neuromuscular process controlling balance	cacna1da	IMP	ZFIN:ZDB-GENO-980410-316	Zfish	PMID:15115817
Biological Process	GO:0050885	neuromuscular process controlling balance	cacna1da	IMP	ZFIN:ZDB-GENO-040525-1	Zfish	PMID:15115817
Biological Process	GO:0021554	optic nerve development	Cacna1d	IEP		Rat	PMID:22473424\|RGD:10411906
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	Cacna1d	IDA		Mouse	MGI:MGI:6243790\|PMID:24086669
Biological Process	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Cacna1d	IMP		Rat	PMID:25675390\|RGD:13782366
Biological Process	GO:0051928	positive regulation of calcium ion transport	CACNA1D	IDA		Human	PMID:1309651
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	Cacna1d	IMP		Rat	PMID:16706838\|RGD:6906921
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Cacna1d	IMP		Rat	PMID:23229155\|RGD:13506727
Biological Process	GO:1904181	positive regulation of membrane depolarization	Cacna1d	IDA		Rat	PMID:7760845\|RGD:70680
Biological Process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	Cacna1d	IMP		Mouse	MGI:MGI:3771286\|PMID:17110593
Biological Process	GO:0051924	regulation of calcium ion transport	Cacna1d	IDA		Rat	PMID:21859974\|RGD:6767284
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	CACNA1D	IMP		Human	PMID:21131953
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	Cacna1d	IMP	MGI:MGI:2180141	Mouse	PMID:12700358
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	Cacna1d	IMP		Mouse	MGI:MGI:3771286\|PMID:17110593
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	Cacna1d	IMP		Mouse	MGI:MGI:3771286\|PMID:17110593
Biological Process	GO:0032355	response to estradiol	Cacna1d	IEP		Rat	PMID:19593990\|RGD:13782367
Biological Process	GO:0007605	sensory perception of sound	CACNA1D	IMP		Human	PMID:21131953
Biological Process	GO:0007605	sensory perception of sound	Cacna1d	IMP	MGI:MGI:2180141	Mouse	PMID:17074442
Biological Process	GO:0050808	synapse organization	cacna1da	IGI	ZFIN:ZDB-GENO-121214-7	Zfish	PMID:23197719
Biological Process	GO:0050808	synapse organization	cacna1da	IGI	ZFIN:ZDB-GENO-121214-8	Zfish	PMID:23197719

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.