Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CACNA1S
  • Mouse genes Cacna1s
  • Rat genes Cacna1s
  • Zfish genes cacna1sa,cacna1sb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cacna1s

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	CACNA1S	IDA		Human	PMID:9852570
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	Cacna1s	IDA		Rat	PMID:7479909|RGD:634679
Molecular Function	GO:0140677	molecular function activator activity	CACNA1S	EXP		Human	PMID:18761102
Molecular Function	GO:0140677	molecular function activator activity	CACNA1S	EXP		Human	PMID:21525002
Molecular Function	GO:0005515	protein binding	CACNA1S	IPI	UniProtKB:Q9H2K2	Human	PMID:12080061
Molecular Function	GO:0005515	protein binding	CACNA1S	IPI	UniProtKB:Q9H2K2	Human	PMID:22153077
Molecular Function	GO:0005515	protein binding	CACNA1S	IPI	UniProtKB:Q86UT5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CACNA1S	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CACNA1S	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CACNA1S	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CACNA1S	IPI	UniProtKB:Q9BWC9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	cacna1sb	IPI	ZFIN:ZDB-GENE-040801-248	Zfish	PMID:23736855
Molecular Function	GO:0036094	small molecule binding	CACNA1S	EXP		Human	PMID:18761102
Molecular Function	GO:0036094	small molecule binding	CACNA1S	EXP		Human	PMID:21525002
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA1S	IDA		Human	PMID:9852570
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:9929471
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna1s	IDA		Mouse	PMID:12954602
Cellular Component	GO:0005737	cytoplasm	CACNA1S	IDA		Human	PMID:11206130
Cellular Component	GO:0044327	dendritic spine head	Cacna1s	IDA		Rat	PMID:24519419|RGD:11340724
Cellular Component	GO:0031674	I band	CACNA1S	IDA		Human	PMID:11206130
Cellular Component	GO:0005886	plasma membrane	CACNA1S	IDA		Human	PMID:11206130
Cellular Component	GO:0042383	sarcolemma	Cacna1s	IDA		Rat	PMID:21474431|RGD:7175530
Cellular Component	GO:0016529	sarcoplasmic reticulum	Cacna1s	IDA		Mouse	PMID:8943043
Cellular Component	GO:0016529	sarcoplasmic reticulum	Cacna1s	IDA		Mouse	PMID:16403451
Cellular Component	GO:0016529	sarcoplasmic reticulum	Cacna1s	IDA		Mouse	PMID:12954602
Cellular Component	GO:0016529	sarcoplasmic reticulum	Cacna1s	IDA		Mouse	PMID:15536090
Cellular Component	GO:0030315	T-tubule	CACNA1S	IDA		Human	PMID:17204937
Cellular Component	GO:0030315	T-tubule	Cacna1s	IDA		Mouse	PMID:15536090
Cellular Component	GO:0030315	T-tubule	Cacna1s	IDA		Mouse	PMID:8943043
Cellular Component	GO:0030315	T-tubule	Cacna1s	IDA		Mouse	PMID:10444070
Cellular Component	GO:0005891	voltage-gated calcium channel complex	CACNA1S	IDA		Human	PMID:9852570
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacna1s	IDA		Rat	PMID:7479909|RGD:634679
Biological Process	GO:0006816	calcium ion transport	CACNA1S	IDA		Human	PMID:9852570
Biological Process	GO:0006816	calcium ion transport	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:1663002
Biological Process	GO:0006816	calcium ion transport	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:10929205
Biological Process	GO:0006816	calcium ion transport	Cacna1s	IDA		Mouse	PMID:12954602
Biological Process	GO:0006816	calcium ion transport	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:9929471
Biological Process	GO:0006816	calcium ion transport	Cacna1s	IDA		Rat	PMID:7479909|RGD:634679
Biological Process	GO:0007029	endoplasmic reticulum organization	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:5041196
Biological Process	GO:0002074	extraocular skeletal muscle development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:14618389
Biological Process	GO:0055001	muscle cell development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:5041196
Biological Process	GO:0006936	muscle contraction	CACNA1S	IMP		Human	PMID:17418573
Biological Process	GO:0006936	muscle contraction	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:6708965
Biological Process	GO:0006936	muscle contraction	Cacna1s	IDA		Mouse	PMID:8143864
Biological Process	GO:0006936	muscle contraction	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:6708966
Biological Process	GO:0006936	muscle contraction	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:4738109
Biological Process	GO:0007520	myoblast fusion	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:10949052
Biological Process	GO:0007528	neuromuscular junction development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:6692972
Biological Process	GO:0007528	neuromuscular junction development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:7286424
Biological Process	GO:0007528	neuromuscular junction development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:6692971
Biological Process	GO:0043501	skeletal muscle adaptation	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:2419767
Biological Process	GO:0048741	skeletal muscle fiber development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:289331
Biological Process	GO:0048741	skeletal muscle fiber development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:8462749
Biological Process	GO:0048741	skeletal muscle fiber development	Cacna1s	IDA		Mouse	PMID:8143864
Biological Process	GO:0007519	skeletal muscle tissue development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:14300096
Biological Process	GO:0007519	skeletal muscle tissue development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:6500174
Biological Process	GO:0007519	skeletal muscle tissue development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:7635187
Biological Process	GO:0007519	skeletal muscle tissue development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:14300095
Biological Process	GO:0001501	skeletal system development	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:6501560
Biological Process	GO:0006941	striated muscle contraction	Cacna1s	IMP	MGI:MGI:1856326	Mouse	PMID:1281468

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern