Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CACNA2D1
  • Mouse genes Cacna2d1
  • Rat genes Cacna2d1
  • Zfish genes cacna2d1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cacna2d1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Cacna2d1	IPI	UniProtKB:P04925	Mouse	MGI:MGI:5440396|PMID:22542184
Molecular Function	GO:0005515	protein binding	Cacna2d1	IPI	PR:P42859	Mouse	PMID:17500595
Molecular Function	GO:0005515	protein binding	Cacna2d1	IPI	UniProtKB:P35442	Rat	PMID:19818485|RGD:8553976
Molecular Function	GO:0005515	protein binding	cacna2d1a	IPI	ZFIN:ZDB-GENE-040801-248	Zfish	PMID:23736855
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA2D1	IDA		Human	PMID:11160515
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA2D1	IDA		Human	PMID:17224476
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA2D1	IDA		Human	PMID:1309651
Molecular Function	GO:0005245	voltage-gated calcium channel activity	CACNA2D1	IGI	UniProtKB:O00555,UniProtKB:Q02641	Human	PMID:21883149
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Cacna2d1	IMP		Rat	PMID:11604404|RGD:625474
Molecular Function	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential	CACNA2D1	IMP		Human	PMID:21383000
Cellular Component	GO:0070062	extracellular exosome	CACNA2D1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CACNA2D1	HDA		Human	PMID:23533145
Cellular Component	GO:0098978	glutamatergic synapse	Cacna2d1	IDA		Rat	PMID:19339603|RGD:13702164
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	CACNA2D1	IDA		Human	PMID:1309651
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	Cacna2d1	IDA		Rat	PMID:25527503|RGD:11059598
Cellular Component	GO:0098992	neuronal dense core vesicle	Cacna2d1	IDA		Mouse	PMID:21321602
Cellular Component	GO:0098992	neuronal dense core vesicle	Cacna2d1	EXP		Mouse	PMID:21321602
Cellular Component	GO:0045211	postsynaptic membrane	Cacna2d1	IDA		Rat	PMID:19339603|RGD:13702164
Cellular Component	GO:0048787	presynaptic active zone membrane	Cacna2d1	IDA		Rat	PMID:19339603|RGD:13702164
Cellular Component	GO:0016529	sarcoplasmic reticulum	Cacna2d1	IDA		Mouse	PMID:15536090
Cellular Component	GO:0030315	T-tubule	Cacna2d1	IDA		Mouse	PMID:15536090
Cellular Component	GO:0005891	voltage-gated calcium channel complex	CACNA2D1	IDA		Human	PMID:11160515
Cellular Component	GO:0005891	voltage-gated calcium channel complex	CACNA2D1	IDA		Human	PMID:17224476
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacna2d1	IMP	MGI:MGI:4353680	Mouse	PMID:28115397
Cellular Component	GO:0005891	voltage-gated calcium channel complex	Cacna2d1	IDA		Rat	PMID:21611731|RGD:7205480
Biological Process	GO:0070588	calcium ion transmembrane transport	Cacna2d1	IDA		Rat	PMID:25527503|RGD:11059598
Biological Process	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel	Cacna2d1	IDA		Rat	PMID:25527503|RGD:11059598
Biological Process	GO:0006816	calcium ion transport	CACNA2D1	IDA		Human	PMID:11160515
Biological Process	GO:0006816	calcium ion transport	CACNA2D1	IDA		Human	PMID:1309651
Biological Process	GO:0060402	calcium ion transport into cytosol	Cacna2d1	IDA		Rat	PMID:25527503|RGD:11059598
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	CACNA2D1	IMP		Human	PMID:25527503
Biological Process	GO:1904646	cellular response to amyloid-beta	CACNA2D1	IGI	UniProtKB:O00555,UniProtKB:Q02641	Human	PMID:21883149
Biological Process	GO:0086048	membrane depolarization during bundle of His cell action potential	CACNA2D1	IMP		Human	PMID:21383000
Biological Process	GO:1901843	positive regulation of high voltage-gated calcium channel activity	Cacna2d1	IDA		Rat	PMID:25527503|RGD:11059598
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	Cacna2d1	IDA		Rat	PMID:20478999|RGD:13514093
Biological Process	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA2D1	IGI	UniProtKB:O00555,UniProtKB:P05067:PRO_0000000092,UniProtKB:Q02641	Human	PMID:21883149
Biological Process	GO:0051924	regulation of calcium ion transport	CACNA2D1	IDA		Human	PMID:1309651
Biological Process	GO:0051924	regulation of calcium ion transport	Cacna2d1	IMP		Mouse	PMID:15536090
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	CACNA2D1	IMP		Human	PMID:25527503
Biological Process	GO:0098903	regulation of membrane repolarization during action potential	Cacna2d1	IDA		Rat	PMID:25527503|RGD:11059598
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	CACNA2D1	IMP		Human	PMID:25527503

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern