Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CACTIN
  • Mouse genes Cactin
  • Rat genes Cactin
  • Zfish genes cactin
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cactin

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CACTIN	IPI	UniProtKB:Q9UBC1	Human	PMID:20829348
Molecular Function	GO:0005515	protein binding	CACTIN	IPI	UniProtKB:Q9HCM9-2	Human	PMID:26363554
Molecular Function	GO:0005515	protein binding	CACTIN	IPI	UniProtKB:P49760	Human	PMID:32296183
Molecular Function	GO:0003723	RNA binding	CACTIN	HDA		Human	PMID:22681889
Cellular Component	GO:0071013	catalytic step 2 spliceosome	CACTIN	IDA		Human	PMID:11991638
Cellular Component	GO:0005829	cytosol	CACTIN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	CACTIN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CACTIN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CACTIN	IDA		Human	PMID:15302935
Cellular Component	GO:0005634	nucleus	CACTIN	IDA		Human	PMID:20829348
Cellular Component	GO:0005634	nucleus	CACTIN	IDA		Human	PMID:28062851
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	cactin	IMP		Zfish	PMID:20348034|ZFIN:ZDB-PUB-100330-40
Biological Process	GO:0071347	cellular response to interleukin-1	CACTIN	IDA		Human	PMID:20829348
Biological Process	GO:0071222	cellular response to lipopolysaccharide	CACTIN	IDA		Human	PMID:20829348
Biological Process	GO:0071356	cellular response to tumor necrosis factor	CACTIN	IDA		Human	PMID:20829348
Biological Process	GO:0001654	eye development	cactin	IMP		Zfish	PMID:20348034|ZFIN:ZDB-PUB-100330-40
Biological Process	GO:0000398	mRNA splicing, via spliceosome	CACTIN	IMP		Human	PMID:28062851
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	CACTIN	IDA		Human	PMID:26363554
Biological Process	GO:0032688	negative regulation of interferon-beta production	CACTIN	IMP		Human	PMID:20829348
Biological Process	GO:0032717	negative regulation of interleukin-8 production	CACTIN	IDA		Human	PMID:20829348
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	CACTIN	IMP		Human	PMID:20829348
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	CACTIN	IDA		Human	PMID:20829348
Biological Process	GO:0001933	negative regulation of protein phosphorylation	CACTIN	IMP		Human	PMID:20829348
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	CACTIN	IDA		Human	PMID:20829348
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	CACTIN	IDA		Human	PMID:20829348
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	CACTIN	IMP		Human	PMID:20829348
Biological Process	GO:0003407	neural retina development	cactin	IMP	ZFIN:ZDB-MRPHLNO-100726-2	Zfish	PMID:20348034
Biological Process	GO:0040019	positive regulation of embryonic development	cactin	IMP		Zfish	PMID:20348034|ZFIN:ZDB-PUB-100330-40

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern