Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CADM4
  • Mouse genes Cadm4
  • Rat genes Cadm4
  • Zfish genes cadm4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cadm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	cadm4	IPI	UniProtKB:B0CLV6	Zfish	PMID:20802085|ZFIN:ZDB-PUB-100910-6
Molecular Function	GO:0005515	protein binding	cadm4	IPI	UniProtKB:Q6PFK4	Zfish	PMID:20802085|ZFIN:ZDB-PUB-100910-6
Molecular Function	GO:0005515	protein binding	cadm4	IPI	UniProtKB:B0CLV6	Zfish	PMID:26190107|ZFIN:ZDB-PUB-150721-6
Molecular Function	GO:0005515	protein binding	cadm4	IPI	UniProtKB:Q6PFK4	Zfish	PMID:26190107|ZFIN:ZDB-PUB-150721-6
Molecular Function	GO:0019903	protein phosphatase binding	Cadm4	IPI	UniProtKB:Q12923	Mouse	MGI:MGI:6270911|PMID:23611113
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Cadm4	IPI	UniProtKB:P21860	Mouse	MGI:MGI:6270911|PMID:23611113
Molecular Function	GO:0043183	vascular endothelial growth factor receptor 1 binding	Cadm4	IPI	UniProtKB:P35969	Mouse	MGI:MGI:6271409|PMID:25893857
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	CADM4	IPI	UniProtKB:P35968	Human	PMID:25893857
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	Cadm4	IPI	UniProtKB:P35968	Mouse	MGI:MGI:6271409|PMID:25893857
Cellular Component	GO:0031252	cell leading edge	CADM4	IDA		Human	PMID:25893857
Cellular Component	GO:0044291	cell-cell contact zone	CADM4	IDA		Human	PMID:25893857
Biological Process	GO:0003234	bulbus arteriosus formation	cadm4	IMP	ZFIN:ZDB-MRPHLNO-140811-9	Zfish	PMID:24813897
Biological Process	GO:0021782	glial cell development	cadm4	IMP	ZFIN:ZDB-CRISPR-191009-78,ZFIN:ZDB-CRISPR-191009-79	Zfish	PMID:30924555
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	CADM4	IMP		Human	PMID:23611113
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	Cadm4	IMP		Mouse	MGI:MGI:6270911|PMID:23611113
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	CADM4	IMP		Human	PMID:23611113
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Cadm4	IMP		Mouse	MGI:MGI:6270911|PMID:23611113
Biological Process	GO:0001933	negative regulation of protein phosphorylation	CADM4	IMP		Human	PMID:25893857
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:2000145	regulation of cell motility	CADM4	IMP		Human	PMID:25893857
Biological Process	GO:2000145	regulation of cell motility	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:0042127	regulation of cell population proliferation	CADM4	IMP		Human	PMID:25893857
Biological Process	GO:0042127	regulation of cell population proliferation	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:0001932	regulation of protein phosphorylation	CADM4	IMP		Human	PMID:25893857
Biological Process	GO:0001932	regulation of protein phosphorylation	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:0035020	regulation of Rac protein signal transduction	CADM4	IMP		Human	PMID:25893857
Biological Process	GO:0035020	regulation of Rac protein signal transduction	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:0061041	regulation of wound healing	CADM4	IMP		Human	PMID:25893857
Biological Process	GO:0061041	regulation of wound healing	Cadm4	IMP		Mouse	MGI:MGI:6271409|PMID:25893857
Biological Process	GO:0060041	retina development in camera-type eye	cadm4	IMP	ZFIN:ZDB-CRISPR-191009-78,ZFIN:ZDB-CRISPR-191009-79	Zfish	PMID:30924555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern