Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CALCA,CALCB
  • Mouse genes Calca
  • Rat genes Calca
  • Zfish genes calca
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Calca

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031716	calcitonin receptor binding	CALCA	IPI	UniProtKB:P30988-2	Human	PMID:8078488
Molecular Function	GO:0031716	calcitonin receptor binding	CALCA	IPI	UniProtKB:P79222-1	Human	PMID:8940110
Molecular Function	GO:0031716	calcitonin receptor binding	CALCA	IPI	UniProtKB:P79222-2	Human	PMID:8940110
Molecular Function	GO:0031716	calcitonin receptor binding	Calca	IDA		Mouse	PMID:9322931
Molecular Function	GO:0042802	identical protein binding	CALCA	IPI	UniProtKB:P01258	Human	PMID:23395606
Molecular Function	GO:0005515	protein binding	CALCA	IPI	UniProtKB:P23634	Human	PMID:17689535
Molecular Function	GO:0005515	protein binding	CALCA	IPI	UniProtKB:Q01814	Human	PMID:17689535
Molecular Function	GO:0005515	protein binding	CALCA	IPI	UniProtKB:X5D778	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CALCB	IPI	UniProtKB:Q99828	Human	PMID:32296183
Molecular Function	GO:0005102	signaling receptor binding	Calca	IDA		Mouse	PMID:7698182
Molecular Function	GO:0005102	signaling receptor binding	Calca	IDA		Mouse	PMID:8278635
Cellular Component	GO:0030424	axon	Calca	IDA		Mouse	PMID:8261138
Cellular Component	GO:0030424	axon	Calca	IDA		Mouse	PMID:8582325
Cellular Component	GO:0030424	axon	Calca	IDA		Mouse	PMID:7521790
Cellular Component	GO:0030424	axon	Calca	IDA		Mouse	PMID:21606356
Cellular Component	GO:0030424	axon	Calca	IDA		Rat	PMID:11836000|RGD:9686421
Cellular Component	GO:0030424	axon	Calca	IDA		Rat	PMID:15535136|RGD:1598599
Cellular Component	GO:0005737	cytoplasm	Calca	IDA		Mouse	PMID:9271704
Cellular Component	GO:0005737	cytoplasm	Calca	IDA		Mouse	PMID:11551509
Cellular Component	GO:0005576	extracellular region	Calca	IDA		Mouse	PMID:8735980
Cellular Component	GO:0005615	extracellular space	CALCA	IDA		Human	PMID:18057382
Cellular Component	GO:0005615	extracellular space	Calca	IDA		Rat	PMID:11208722|RGD:8553462
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Calca	IDA		Rat	PMID:9383204|RGD:155230740
Cellular Component	GO:0005622	intracellular anatomical structure	Calca	IDA		Mouse	PMID:12888222
Cellular Component	GO:0005622	intracellular anatomical structure	Calca	IDA		Mouse	PMID:7955356
Cellular Component	GO:0043005	neuron projection	Calca	IDA		Mouse	PMID:11466438
Cellular Component	GO:0043025	neuronal cell body	Calca	IDA		Rat	PMID:11836000|RGD:9686421
Cellular Component	GO:0098992	neuronal dense core vesicle	Calca	IDA		Rat	PMID:9383204|RGD:155230740
Cellular Component	GO:0005634	nucleus	Calca	IDA		Rat	PMID:16763782|RGD:1600608
Cellular Component	GO:0043195	terminal bouton	Calca	IDA		Mouse	PMID:8453761
Cellular Component	GO:0043195	terminal bouton	Calca	IDA		Mouse	PMID:10532808
Cellular Component	GO:0043195	terminal bouton	Calca	IDA		Mouse	PMID:10208559
Cellular Component	GO:0043195	terminal bouton	Calca	IDA		Mouse	PMID:9853118
Biological Process	GO:0007190	activation of adenylate cyclase activity	Calca	IDA		Mouse	PMID:8582325
Biological Process	GO:0032147	activation of protein kinase activity	CALCA	IDA		Human	PMID:17983652
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCA	IDA		Human	PMID:11014233
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCA	IDA		Human	PMID:8078488
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Calca	IGI	MGI:MGI:1926944	Mouse	PMID:8582325
Biological Process	GO:0007568	aging	Calca	IEP		Rat	PMID:19152794|RGD:2314033
Biological Process	GO:0001984	artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure	Calca	IMP	MGI:MGI:2445489	Mouse	PMID:11717154
Biological Process	GO:0055074	calcium ion homeostasis	calca	IMP	ZFIN:ZDB-MRPHLNO-120227-7	Zfish	PMID:21542008
Biological Process	GO:0007155	cell adhesion	Calca	IDA		Mouse	MGI:MGI:78878
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Calca	IDA		Mouse	PMID:24760869
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Calca	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Calca	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0055064	chloride ion homeostasis	calca	IMP	ZFIN:ZDB-MRPHLNO-120227-7	Zfish	PMID:27306053
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Calca	IMP		Mouse	PMID:16118273
Biological Process	GO:0007566	embryo implantation	CALCA	IDA		Human	PMID:17983652
Biological Process	GO:0007631	feeding behavior	Calca	IDA		Mouse	PMID:8735980
Biological Process	GO:0006954	inflammatory response	Calca	IDA		Mouse	PMID:7698182
Biological Process	GO:0006954	inflammatory response	Calca	IEP		Rat	PMID:21958434|RGD:8657122
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Calca	IGI	MGI:MGI:97799	Mouse	PMID:12488435
Biological Process	GO:0002548	monocyte chemotaxis	CALCA	IDA		Human	PMID:15248232
Biological Process	GO:0045776	negative regulation of blood pressure	Calca	IMP	MGI:MGI:3527257	Mouse	PMID:10642343
Biological Process	GO:0045776	negative regulation of blood pressure	Calca	IMP	MGI:MGI:3527257	Mouse	PMID:15583078
Biological Process	GO:0045776	negative regulation of blood pressure	Calca	IMP		Rat	PMID:11230364|RGD:68890
Biological Process	GO:0045779	negative regulation of bone resorption	CALCA	IDA		Human	PMID:17241109
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CALCA	IDA		Human	PMID:11014233
Biological Process	GO:0030279	negative regulation of ossification	Calca	IMP	MGI:MGI:3527257	Mouse	PMID:12488435
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Calca	IDA		Mouse	PMID:9322931
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Calca	IMP		Rat	PMID:11230364|RGD:68890
Biological Process	GO:0007218	neuropeptide signaling pathway	Calca	IDA		Mouse	PMID:7698182
Biological Process	GO:0001503	ossification	Calca	IMP	MGI:MGI:3527257	Mouse	PMID:12488435
Biological Process	GO:0045785	positive regulation of cell adhesion	Calca	IDA		Mouse	MGI:MGI:78878
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	CALCA	IDA		Human	PMID:17983652
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	CALCA	IDA		Human	PMID:8078488
Biological Process	GO:0008016	regulation of heart contraction	Calca	IDA		Rat	PMID:12903912|RGD:1598597
Biological Process	GO:0009408	response to heat	Calca	IMP	MGI:MGI:3527257	Mouse	PMID:11166483
Biological Process	GO:0048265	response to pain	Calca	IMP	MGI:MGI:2148771	Mouse	PMID:10208559
Biological Process	GO:0006939	smooth muscle contraction	Calca	IDA		Mouse	PMID:9322931
Biological Process	GO:0042311	vasodilation	Calca	IDA		Rat	PMID:12903912|RGD:1598597

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern