Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CALCRL
  • Mouse genes Calcrl
  • Rat genes Calcrl
  • Zfish genes calcrla,calcrlb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Calcrl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990409	adrenomedullin binding	CALCRL	IPI	UniProtKB:O60895	Human	PMID:20074556
Molecular Function	GO:1990409	adrenomedullin binding	CALCRL	IPI	UniProtKB:O60895	Human	PMID:22102369
Molecular Function	GO:0001605	adrenomedullin receptor activity	CALCRL	IPI	UniProtKB:O60896	Human	PMID:10882736
Molecular Function	GO:0001605	adrenomedullin receptor activity	CALCRL	IPI	UniProtKB:O60895	Human	PMID:20074556
Molecular Function	GO:0001605	adrenomedullin receptor activity	CALCRL	IPI	UniProtKB:O60895	Human	PMID:22102369
Molecular Function	GO:0001605	adrenomedullin receptor activity	CALCRL	IPI	UniProtKB:O60895	Human	PMID:9620797
Molecular Function	GO:0001635	calcitonin gene-related peptide receptor activity	CALCRL	IPI	UniProtKB:O60894	Human	PMID:10882736
Molecular Function	GO:0001635	calcitonin gene-related peptide receptor activity	CALCRL	IPI	UniProtKB:O60894	Human	PMID:9620797
Molecular Function	GO:0001635	calcitonin gene-related peptide receptor activity	Calcrl	IGI	MGI:MGI:2151253	Mouse	PMID:8582325
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:O60894	Human	PMID:16293613
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:O60894	Human	PMID:20596610
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:O60895	Human	PMID:20596610
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:O60894	Human	PMID:20826335
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:O60895	Human	PMID:22102369
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:P06881	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:O60895	Human	PMID:30115739
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:P06881	Human	PMID:30209400
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:O60894	Human	PMID:33602864
Molecular Function	GO:0005515	protein binding	CALCRL	IPI	UniProtKB:P06881	Human	PMID:33602864
Cellular Component	GO:1903143	adrenomedullin receptor complex	CALCRL	IDA		Human	PMID:10882736
Cellular Component	GO:1903143	adrenomedullin receptor complex	CALCRL	IDA		Human	PMID:20074556
Cellular Component	GO:1903143	adrenomedullin receptor complex	CALCRL	IDA		Human	PMID:22102369
Cellular Component	GO:1903143	adrenomedullin receptor complex	CALCRL	IDA		Human	PMID:9620797
Cellular Component	GO:1990406	CGRP receptor complex	CALCRL	IDA		Human	PMID:10882736
Cellular Component	GO:1990406	CGRP receptor complex	CALCRL	IDA		Human	PMID:9620797
Cellular Component	GO:0005737	cytoplasm	CALCRL	IDA		Human	PMID:10882736
Cellular Component	GO:0005783	endoplasmic reticulum	CALCRL	IDA		Human	PMID:10882736
Cellular Component	GO:0005768	endosome	CALCRL	IDA		Human	PMID:10882736
Cellular Component	GO:0005764	lysosome	CALCRL	IDA		Human	PMID:10882736
Cellular Component	GO:0098992	neuronal dense core vesicle	Calcrl	IDA		Rat	PMID:17614212|RGD:155230744
Cellular Component	GO:0005886	plasma membrane	CALCRL	IDA		Human	PMID:9620797
Cellular Component	GO:0005886	plasma membrane	CALCRL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CALCRL	IDA		Human	PMID:10882736
Cellular Component	GO:0005886	plasma membrane	CALCRL	IDA		Human	PMID:18039931
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCRL	IPI	UniProtKB:O60894	Human	PMID:10882736
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:10882736
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCRL	IPI	UniProtKB:O60896	Human	PMID:10882736
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:20074556
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:22102369
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCRL	IPI	UniProtKB:O60894	Human	PMID:9620797
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:9620797
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Calcrl	IMP		Mouse	PMID:8582325
Biological Process	GO:1990410	adrenomedullin receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:10882736
Biological Process	GO:1990410	adrenomedullin receptor signaling pathway	CALCRL	IPI	UniProtKB:O60896	Human	PMID:10882736
Biological Process	GO:1990410	adrenomedullin receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:20074556
Biological Process	GO:1990410	adrenomedullin receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:22102369
Biological Process	GO:1990410	adrenomedullin receptor signaling pathway	CALCRL	IPI	UniProtKB:O60895	Human	PMID:9620797
Biological Process	GO:0001525	angiogenesis	CALCRL	IDA		Human	PMID:20596610
Biological Process	GO:0001525	angiogenesis	calcrla	IMP	ZFIN:ZDB-MRPHLNO-080924-4	Zfish	PMID:18326814
Biological Process	GO:0001525	angiogenesis	calcrla	IMP	ZFIN:ZDB-MRPHLNO-080924-3	Zfish	PMID:18326814
Biological Process	GO:0048844	artery morphogenesis	calcrla	IMP	ZFIN:ZDB-MRPHLNO-080924-3	Zfish	PMID:18326814
Biological Process	GO:0048844	artery morphogenesis	calcrla	IMP	ZFIN:ZDB-MRPHLNO-080924-4	Zfish	PMID:18326814
Biological Process	GO:1990408	calcitonin gene-related peptide receptor signaling pathway	CALCRL	IPI	UniProtKB:O60894	Human	PMID:10882736
Biological Process	GO:1990408	calcitonin gene-related peptide receptor signaling pathway	CALCRL	IPI	UniProtKB:O60894	Human	PMID:9620797
Biological Process	GO:0006816	calcium ion transport	CALCRL	IDA		Human	PMID:10882736
Biological Process	GO:0008283	cell population proliferation	Calcrl	IMP		Mouse	PMID:16537897
Biological Process	GO:0071329	cellular response to sucrose stimulus	CALCRL	IDA		Human	PMID:10882736
Biological Process	GO:0055064	chloride ion homeostasis	calcrla	IMP	ZFIN:ZDB-MRPHLNO-160902-1	Zfish	PMID:27306053
Biological Process	GO:0007507	heart development	Calcrl	IMP		Mouse	PMID:16537897
Biological Process	GO:0050728	negative regulation of inflammatory response	Calcrl	IMP		Rat	PMID:17363466|RGD:1625357
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Calcrl	IMP		Rat	PMID:17363466|RGD:1625357
Biological Process	GO:0008284	positive regulation of cell population proliferation	Calcrl	IMP		Mouse	PMID:16537897
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Calcrl	IMP		Mouse	PMID:16537897
Biological Process	GO:0015031	protein transport	CALCRL	IDA		Human	PMID:9620797
Biological Process	GO:0031623	receptor internalization	CALCRL	IDA		Human	PMID:10882736
Biological Process	GO:0031623	receptor internalization	CALCRL	IDA		Human	PMID:20074556
Biological Process	GO:0048659	smooth muscle cell proliferation	Calcrl	IMP		Mouse	PMID:16537897
Biological Process	GO:0001756	somitogenesis	calcrla	IGI	ZFIN:ZDB-GENO-070406-1,ZFIN:ZDB-MRPHLNO-080924-3	Zfish	PMID:18326814
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	Calcrl	IMP		Mouse	PMID:16537897

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern