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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Calm2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Calm2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0010856adenylate cyclase activator activityCALM2IDAHumanPMID:11807546
Molecular FunctionGO:0008179adenylate cyclase bindingCALM2IPIUniProtKB:P40136HumanPMID:11807546
Molecular FunctionGO:0019855calcium channel inhibitor activityCALM2IDAHumanPMID:26969752
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:11807546
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:23040497
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:26164367
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:26969752
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:27516456
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:35568036
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:7607248
Molecular FunctionGO:0005509calcium ion bindingCALM2IDAHumanPMID:8631777
Molecular FunctionGO:0005509calcium ion bindingCalm1IDARatPMID:15628869|RGD:7241270
Molecular FunctionGO:0005509calcium ion bindingCalm1IDARatPMID:23109337|RGD:7241220
Molecular FunctionGO:0005509calcium ion bindingCalm2IDARatPMID:15628869|RGD:7241270
Molecular FunctionGO:0005509calcium ion bindingCalm2IDARatPMID:23109337|RGD:7241220
Molecular FunctionGO:0005509calcium ion bindingCalm3IDARatPMID:15628869|RGD:7241270
Molecular FunctionGO:0005509calcium ion bindingCalm3IDARatPMID:23109337|RGD:7241220
Molecular FunctionGO:0048306calcium-dependent protein bindingCalm2IPIUniProtKB:Q8CGQ8MouseMGI:MGI:6716978|PMID:33199372
Molecular FunctionGO:0048306calcium-dependent protein bindingCalm1IPIRGD:736657RatPMID:12032157|RGD:634683
Molecular FunctionGO:0048306calcium-dependent protein bindingCalm1IPIRGD:2745RatPMID:21855531|RGD:7207139
Molecular FunctionGO:0048306calcium-dependent protein bindingCalm1IPIRGD:619857RatPMID:21855531|RGD:7207139
Molecular FunctionGO:0050998nitric-oxide synthase bindingCalm1IDARatPMID:20529840|RGD:7241266
Molecular FunctionGO:0050998nitric-oxide synthase bindingCalm2IDARatPMID:20529840|RGD:7241266
Molecular FunctionGO:0050998nitric-oxide synthase bindingCalm3IDARatPMID:20529840|RGD:7241266
Molecular FunctionGO:0030235nitric-oxide synthase regulator activityCalm1IDARatPMID:20529840|RGD:7241266
Molecular FunctionGO:0030235nitric-oxide synthase regulator activityCalm2IDARatPMID:20529840|RGD:7241266
Molecular FunctionGO:0030235nitric-oxide synthase regulator activityCalm3IDARatPMID:20529840|RGD:7241266
Molecular FunctionGO:0043548phosphatidylinositol 3-kinase bindingCalm1IPIRGD:3329RatPMID:17492691|RGD:4108506
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:P11171HumanPMID:10692436
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:Q99698HumanPMID:11984006
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:Q13936HumanPMID:15140941
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:P03406HumanPMID:15632291
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:O43303HumanPMID:16760425
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:P02687HumanPMID:19855925
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:P04370HumanPMID:19855925
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:P81558HumanPMID:19855925
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:Q13576HumanPMID:21299499
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:Q86VI3HumanPMID:21299499
Molecular FunctionGO:0005515protein bindingCALM2IPIUniProtKB:P10636HumanPMID:3111527
Molecular FunctionGO:0005515protein bindingCalm2IPIUniProtKB:Q8CGQ8MouseMGI:MGI:6716978|PMID:33199372
Molecular FunctionGO:0005515protein bindingCalm1IPIUniProtKB:P35400RatPMID:12021391|RGD:8554716
Molecular FunctionGO:0005515protein bindingCalm2IPIUniProtKB:P35400RatPMID:12021391|RGD:8554716
Molecular FunctionGO:0005515protein bindingCalm3IPIUniProtKB:P35400RatPMID:12021391|RGD:8554716
Molecular FunctionGO:0019904protein domain specific bindingCalm1IPIRGD:2745RatPMID:21855531|RGD:7207139
Molecular FunctionGO:0019904protein domain specific bindingCalm1IPIRGD:619857RatPMID:21855531|RGD:7207139
Molecular FunctionGO:0019901protein kinase bindingCALM2IPIUniProtKB:Q13557HumanPMID:20668654
Molecular FunctionGO:0019901protein kinase bindingCALM2IPIUniProtKB:Q9UQM7HumanPMID:20668654
Molecular FunctionGO:0072542protein phosphatase activator activityCALM2IDAHumanPMID:8631777
Molecular FunctionGO:0043539protein serine/threonine kinase activator activityCALM2IDAHumanPMID:35568036
Molecular FunctionGO:0031432titin bindingCALM2IPIUniProtKB:Q8WZ42HumanPMID:7607248
Molecular FunctionGO:0044325transmembrane transporter bindingCALM2IPIUniProtKB:Q14524HumanPMID:21167176
Molecular FunctionGO:0044325transmembrane transporter bindingCALM2IPIUniProtKB:Q92736HumanPMID:23040497
Molecular FunctionGO:0044325transmembrane transporter bindingCalm1IDARatPMID:15628869|RGD:7241270
Molecular FunctionGO:0044325transmembrane transporter bindingCalm1IDARatPMID:23109337|RGD:7241220
Molecular FunctionGO:0044325transmembrane transporter bindingCalm2IDARatPMID:15628869|RGD:7241270
Molecular FunctionGO:0044325transmembrane transporter bindingCalm2IDARatPMID:23109337|RGD:7241220
Molecular FunctionGO:0044325transmembrane transporter bindingCalm3IDARatPMID:15628869|RGD:7241270
Molecular FunctionGO:0044325transmembrane transporter bindingCalm3IDARatPMID:23109337|RGD:7241220
Molecular FunctionGO:0031800type 3 metabotropic glutamate receptor bindingCalm1IPIRGD:2745RatPMID:21855531|RGD:7207139
Molecular FunctionGO:0031800type 3 metabotropic glutamate receptor bindingCalm1IPIRGD:619857RatPMID:21855531|RGD:7207139
Cellular ComponentGO:0034704calcium channel complexCALM2IDAHumanPMID:23040497
Cellular ComponentGO:1902494catalytic complexCALM2IDAHumanPMID:11807546
Cellular ComponentGO:0005813centrosomeCALM2IDAHumanPMID:16760425
Cellular ComponentGO:0005737cytoplasmCALM2IDAHumanPMID:27165696
Cellular ComponentGO:0005737cytoplasmCalm1IDARatPMID:21912933|RGD:7205683
Cellular ComponentGO:0005737cytoplasmCalm1IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0005737cytoplasmCalm2IDARatPMID:21912933|RGD:7205683
Cellular ComponentGO:0005737cytoplasmCalm2IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0005737cytoplasmCalm3IDARatPMID:21912933|RGD:7205683
Cellular ComponentGO:0005737cytoplasmCalm3IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0030426growth coneCalm1IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0030426growth coneCalm2IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0030426growth coneCalm3IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0016020membraneCalm2IDAMouseMGI:MGI:6716978|PMID:33199372
Cellular ComponentGO:0031966mitochondrial membraneCalm1IMPRatPMID:23792689|RGD:12793033
Cellular ComponentGO:0031966mitochondrial membraneCalm2IMPRatPMID:23792689|RGD:12793033
Cellular ComponentGO:0031966mitochondrial membraneCalm3IMPRatPMID:23792689|RGD:12793033
Cellular ComponentGO:0043209myelin sheathCalm2IDAMouseMGI:MGI:5883208|PMID:19855925
Cellular ComponentGO:0043209myelin sheathCalm1IDARatPMID:19855925|RGD:12793026
Cellular ComponentGO:0043209myelin sheathCalm2IDARatPMID:19855925|RGD:12793026
Cellular ComponentGO:0043209myelin sheathCalm3IDARatPMID:19855925|RGD:12793026
Cellular ComponentGO:0043005neuron projectionCalm1IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0043005neuron projectionCalm2IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0043005neuron projectionCalm3IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0005634nucleusCALM2HDAHumanPMID:21630459
Cellular ComponentGO:0005634nucleusCalm1IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0005634nucleusCalm2IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0005634nucleusCalm3IDARatPMID:7492944|RGD:7241258
Cellular ComponentGO:0005886plasma membraneCalm1IDARatPMID:21912933|RGD:7205683
Cellular ComponentGO:0005886plasma membraneCalm2IDARatPMID:21912933|RGD:7205683
Cellular ComponentGO:0005886plasma membraneCalm3IDARatPMID:21912933|RGD:7205683
Cellular ComponentGO:0032991protein-containing complexCALM2IDAHumanPMID:19855925
Cellular ComponentGO:0030017sarcomereCALM2IDAHumanPMID:20226167
Cellular ComponentGO:0005876spindle microtubuleCALM2IDAHumanPMID:16760425
Cellular ComponentGO:0000922spindle poleCALM2IDAHumanPMID:16760425
Cellular ComponentGO:0030672synaptic vesicle membraneCalm1IMPRatPMID:23792689|RGD:12793033
Cellular ComponentGO:0030672synaptic vesicle membraneCalm2IMPRatPMID:23792689|RGD:12793033
Cellular ComponentGO:0030672synaptic vesicle membraneCalm3IMPRatPMID:23792689|RGD:12793033
Cellular ComponentGO:0031982vesicleCALM2HDAHumanPMID:19190083
Cellular ComponentGO:0031982vesicleCalm2IDAMouseMGI:MGI:6716978|PMID:33199372
Cellular ComponentGO:0008076voltage-gated potassium channel complexCalm2IGIMGI:MGI:88251MousePMID:12223552
Cellular ComponentGO:0008076voltage-gated potassium channel complexCalm2IGIMGI:MGI:103249MousePMID:12223552
Biological ProcessGO:0019722calcium-mediated signalingCalm1IMPRatPMID:20717650|RGD:7207843
Biological ProcessGO:0019722calcium-mediated signalingCalm2IMPRatPMID:20717650|RGD:7207843
Biological ProcessGO:0019722calcium-mediated signalingCalm3IMPRatPMID:20717650|RGD:7207843
Biological ProcessGO:0005513detection of calcium ionCALM2IMPHumanPMID:23040497
Biological ProcessGO:0090150establishment of protein localization to membraneCalm1IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:0090150establishment of protein localization to membraneCalm2IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:0090150establishment of protein localization to membraneCalm3IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:0090151establishment of protein localization to mitochondrial membraneCalm1IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:0090151establishment of protein localization to mitochondrial membraneCalm2IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:0090151establishment of protein localization to mitochondrial membraneCalm3IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:0000086G2/M transition of mitotic cell cycleCalm2IDAMousePMID:2469574
Biological ProcessGO:0021555midbrain-hindbrain boundary morphogenesiscalm1aIMPZFIN:ZDB-MRPHLNO-170519-1ZfishPMID:28148652
Biological ProcessGO:1905913negative regulation of calcium ion export across plasma membraneCalm2IDAMouseMGI:MGI:6716978|PMID:33199372
Biological ProcessGO:1901020negative regulation of calcium ion transmembrane transporter activityCalm2IDAMouseMGI:MGI:6716978|PMID:33199372
Biological ProcessGO:0060315negative regulation of ryanodine-sensitive calcium-release channel activityCALM2IDAHumanPMID:26164367
Biological ProcessGO:0051343positive regulation of cyclic-nucleotide phosphodiesterase activityCALM2IDAHumanPMID:8631777
Biological ProcessGO:0051000positive regulation of nitric-oxide synthase activityCalm1IDARatPMID:20529840|RGD:7241266
Biological ProcessGO:0051000positive regulation of nitric-oxide synthase activityCalm2IDARatPMID:20529840|RGD:7241266
Biological ProcessGO:0051000positive regulation of nitric-oxide synthase activityCalm3IDARatPMID:20529840|RGD:7241266
Biological ProcessGO:0032516positive regulation of phosphoprotein phosphatase activityCALM2IDAHumanPMID:8631777
Biological ProcessGO:0035307positive regulation of protein dephosphorylationCALM2IDAHumanPMID:8631777
Biological ProcessGO:0060316positive regulation of ryanodine-sensitive calcium-release channel activityCALM2IDAHumanPMID:20226167
Biological ProcessGO:0050848regulation of calcium-mediated signalingCalm2IGIUniProtKB:Q8CGQ8MouseMGI:MGI:6716978|PMID:33199372
Biological ProcessGO:0055117regulation of cardiac muscle contractionCALM2IMPHumanPMID:23040497
Biological ProcessGO:0032465regulation of cytokinesisCALM2IMPHumanPMID:16760425
Biological ProcessGO:0002027regulation of heart rateCALM2IMPHumanPMID:23040497
Biological ProcessGO:1901841regulation of high voltage-gated calcium channel activityCalm1IMPRatPMID:18322004|RGD:7207845
Biological ProcessGO:1901841regulation of high voltage-gated calcium channel activityCalm2IMPRatPMID:18322004|RGD:7207845
Biological ProcessGO:1901841regulation of high voltage-gated calcium channel activityCalm3IMPRatPMID:18322004|RGD:7207845
Biological ProcessGO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumCALM2IDAHumanPMID:20226167
Biological ProcessGO:0060314regulation of ryanodine-sensitive calcium-release channel activityCalm1IDARatPMID:15628869|RGD:7241270
Biological ProcessGO:0060314regulation of ryanodine-sensitive calcium-release channel activityCalm2IDARatPMID:15628869|RGD:7241270
Biological ProcessGO:0060314regulation of ryanodine-sensitive calcium-release channel activityCalm3IDARatPMID:15628869|RGD:7241270
Biological ProcessGO:1900242regulation of synaptic vesicle endocytosisCalm1IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:1900242regulation of synaptic vesicle endocytosisCalm2IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:1900242regulation of synaptic vesicle endocytosisCalm3IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:2000300regulation of synaptic vesicle exocytosisCalm1IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:2000300regulation of synaptic vesicle exocytosisCalm2IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:2000300regulation of synaptic vesicle exocytosisCalm3IMPRatPMID:23792689|RGD:12793033
Biological ProcessGO:0001975response to amphetamineCalm1IEPRatPMID:10854758|RGD:6892957
Biological ProcessGO:0001975response to amphetamineCalm2IEPRatPMID:10854758|RGD:6892957
Biological ProcessGO:0001975response to amphetamineCalm3IEPRatPMID:10854758|RGD:6892957
Biological ProcessGO:0051592response to calcium ionCALM2IDAHumanPMID:7607248
Biological ProcessGO:0051412response to corticosteroneCalm2IEPRatPMID:16503919|RGD:6892959
Biological ProcessGO:0021762substantia nigra developmentCALM2HEPHumanPMID:22926577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory