Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Calm2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CALM2
- Mouse genes Calm2
- Rat genes Calm1,Calm2,Calm3
- Zfish genes calm1a,calm1b,calm2a,calm2b,calm3a,calm3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Calm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0010856	adenylate cyclase activator activity	CALM2	IDA		Human	PMID:11807546
Molecular Function	GO:0008179	adenylate cyclase binding	CALM2	IPI	UniProtKB:P40136	Human	PMID:11807546
Molecular Function	GO:0019855	calcium channel inhibitor activity	CALM2	IDA		Human	PMID:26969752
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:11807546
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:23040497
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:26164367
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:26969752
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:27516456
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:35568036
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:7607248
Molecular Function	GO:0005509	calcium ion binding	CALM2	IDA		Human	PMID:8631777
Molecular Function	GO:0005509	calcium ion binding	Calm1	IDA		Rat	PMID:15628869\|RGD:7241270
Molecular Function	GO:0005509	calcium ion binding	Calm1	IDA		Rat	PMID:23109337\|RGD:7241220
Molecular Function	GO:0005509	calcium ion binding	Calm2	IDA		Rat	PMID:15628869\|RGD:7241270
Molecular Function	GO:0005509	calcium ion binding	Calm2	IDA		Rat	PMID:23109337\|RGD:7241220
Molecular Function	GO:0005509	calcium ion binding	Calm3	IDA		Rat	PMID:15628869\|RGD:7241270
Molecular Function	GO:0005509	calcium ion binding	Calm3	IDA		Rat	PMID:23109337\|RGD:7241220
Molecular Function	GO:0048306	calcium-dependent protein binding	Calm2	IPI	UniProtKB:Q8CGQ8	Mouse	MGI:MGI:6716978\|PMID:33199372
Molecular Function	GO:0048306	calcium-dependent protein binding	Calm1	IPI	RGD:736657	Rat	PMID:12032157\|RGD:634683
Molecular Function	GO:0048306	calcium-dependent protein binding	Calm1	IPI	RGD:2745	Rat	PMID:21855531\|RGD:7207139
Molecular Function	GO:0048306	calcium-dependent protein binding	Calm1	IPI	RGD:619857	Rat	PMID:21855531\|RGD:7207139
Molecular Function	GO:0050998	nitric-oxide synthase binding	Calm1	IDA		Rat	PMID:20529840\|RGD:7241266
Molecular Function	GO:0050998	nitric-oxide synthase binding	Calm2	IDA		Rat	PMID:20529840\|RGD:7241266
Molecular Function	GO:0050998	nitric-oxide synthase binding	Calm3	IDA		Rat	PMID:20529840\|RGD:7241266
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	Calm1	IDA		Rat	PMID:20529840\|RGD:7241266
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	Calm2	IDA		Rat	PMID:20529840\|RGD:7241266
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity	Calm3	IDA		Rat	PMID:20529840\|RGD:7241266
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	Calm1	IPI	RGD:3329	Rat	PMID:17492691\|RGD:4108506
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:P11171	Human	PMID:10692436
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:Q99698	Human	PMID:11984006
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:Q13936	Human	PMID:15140941
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:P03406	Human	PMID:15632291
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:O43303	Human	PMID:16760425
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:P02687	Human	PMID:19855925
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:P04370	Human	PMID:19855925
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:P81558	Human	PMID:19855925
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:Q13576	Human	PMID:21299499
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:Q86VI3	Human	PMID:21299499
Molecular Function	GO:0005515	protein binding	CALM2	IPI	UniProtKB:P10636	Human	PMID:3111527
Molecular Function	GO:0005515	protein binding	Calm2	IPI	UniProtKB:Q8CGQ8	Mouse	MGI:MGI:6716978\|PMID:33199372
Molecular Function	GO:0005515	protein binding	Calm1	IPI	UniProtKB:P35400	Rat	PMID:12021391\|RGD:8554716
Molecular Function	GO:0005515	protein binding	Calm2	IPI	UniProtKB:P35400	Rat	PMID:12021391\|RGD:8554716
Molecular Function	GO:0005515	protein binding	Calm3	IPI	UniProtKB:P35400	Rat	PMID:12021391\|RGD:8554716
Molecular Function	GO:0019904	protein domain specific binding	Calm1	IPI	RGD:2745	Rat	PMID:21855531\|RGD:7207139
Molecular Function	GO:0019904	protein domain specific binding	Calm1	IPI	RGD:619857	Rat	PMID:21855531\|RGD:7207139
Molecular Function	GO:0019901	protein kinase binding	CALM2	IPI	UniProtKB:Q13557	Human	PMID:20668654
Molecular Function	GO:0019901	protein kinase binding	CALM2	IPI	UniProtKB:Q9UQM7	Human	PMID:20668654
Molecular Function	GO:0072542	protein phosphatase activator activity	CALM2	IDA		Human	PMID:8631777
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	CALM2	IDA		Human	PMID:35568036
Molecular Function	GO:0031432	titin binding	CALM2	IPI	UniProtKB:Q8WZ42	Human	PMID:7607248
Molecular Function	GO:0044325	transmembrane transporter binding	CALM2	IPI	UniProtKB:Q14524	Human	PMID:21167176
Molecular Function	GO:0044325	transmembrane transporter binding	CALM2	IPI	UniProtKB:Q92736	Human	PMID:23040497
Molecular Function	GO:0044325	transmembrane transporter binding	Calm1	IDA		Rat	PMID:15628869\|RGD:7241270
Molecular Function	GO:0044325	transmembrane transporter binding	Calm1	IDA		Rat	PMID:23109337\|RGD:7241220
Molecular Function	GO:0044325	transmembrane transporter binding	Calm2	IDA		Rat	PMID:15628869\|RGD:7241270
Molecular Function	GO:0044325	transmembrane transporter binding	Calm2	IDA		Rat	PMID:23109337\|RGD:7241220
Molecular Function	GO:0044325	transmembrane transporter binding	Calm3	IDA		Rat	PMID:15628869\|RGD:7241270
Molecular Function	GO:0044325	transmembrane transporter binding	Calm3	IDA		Rat	PMID:23109337\|RGD:7241220
Molecular Function	GO:0031800	type 3 metabotropic glutamate receptor binding	Calm1	IPI	RGD:2745	Rat	PMID:21855531\|RGD:7207139
Molecular Function	GO:0031800	type 3 metabotropic glutamate receptor binding	Calm1	IPI	RGD:619857	Rat	PMID:21855531\|RGD:7207139
Cellular Component	GO:0034704	calcium channel complex	CALM2	IDA		Human	PMID:23040497
Cellular Component	GO:1902494	catalytic complex	CALM2	IDA		Human	PMID:11807546
Cellular Component	GO:0005813	centrosome	CALM2	IDA		Human	PMID:16760425
Cellular Component	GO:0005737	cytoplasm	CALM2	IDA		Human	PMID:27165696
Cellular Component	GO:0005737	cytoplasm	Calm1	IDA		Rat	PMID:21912933\|RGD:7205683
Cellular Component	GO:0005737	cytoplasm	Calm1	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0005737	cytoplasm	Calm2	IDA		Rat	PMID:21912933\|RGD:7205683
Cellular Component	GO:0005737	cytoplasm	Calm2	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0005737	cytoplasm	Calm3	IDA		Rat	PMID:21912933\|RGD:7205683
Cellular Component	GO:0005737	cytoplasm	Calm3	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0030426	growth cone	Calm1	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0030426	growth cone	Calm2	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0030426	growth cone	Calm3	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0016020	membrane	Calm2	IDA		Mouse	MGI:MGI:6716978\|PMID:33199372
Cellular Component	GO:0031966	mitochondrial membrane	Calm1	IMP		Rat	PMID:23792689\|RGD:12793033
Cellular Component	GO:0031966	mitochondrial membrane	Calm2	IMP		Rat	PMID:23792689\|RGD:12793033
Cellular Component	GO:0031966	mitochondrial membrane	Calm3	IMP		Rat	PMID:23792689\|RGD:12793033
Cellular Component	GO:0043209	myelin sheath	Calm2	IDA		Mouse	MGI:MGI:5883208\|PMID:19855925
Cellular Component	GO:0043209	myelin sheath	Calm1	IDA		Rat	PMID:19855925\|RGD:12793026
Cellular Component	GO:0043209	myelin sheath	Calm2	IDA		Rat	PMID:19855925\|RGD:12793026
Cellular Component	GO:0043209	myelin sheath	Calm3	IDA		Rat	PMID:19855925\|RGD:12793026
Cellular Component	GO:0043005	neuron projection	Calm1	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0043005	neuron projection	Calm2	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0043005	neuron projection	Calm3	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0005634	nucleus	CALM2	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	Calm1	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0005634	nucleus	Calm2	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0005634	nucleus	Calm3	IDA		Rat	PMID:7492944\|RGD:7241258
Cellular Component	GO:0005886	plasma membrane	Calm1	IDA		Rat	PMID:21912933\|RGD:7205683
Cellular Component	GO:0005886	plasma membrane	Calm2	IDA		Rat	PMID:21912933\|RGD:7205683
Cellular Component	GO:0005886	plasma membrane	Calm3	IDA		Rat	PMID:21912933\|RGD:7205683
Cellular Component	GO:0032991	protein-containing complex	CALM2	IDA		Human	PMID:19855925
Cellular Component	GO:0030017	sarcomere	CALM2	IDA		Human	PMID:20226167
Cellular Component	GO:0005876	spindle microtubule	CALM2	IDA		Human	PMID:16760425
Cellular Component	GO:0000922	spindle pole	CALM2	IDA		Human	PMID:16760425
Cellular Component	GO:0030672	synaptic vesicle membrane	Calm1	IMP		Rat	PMID:23792689\|RGD:12793033
Cellular Component	GO:0030672	synaptic vesicle membrane	Calm2	IMP		Rat	PMID:23792689\|RGD:12793033
Cellular Component	GO:0030672	synaptic vesicle membrane	Calm3	IMP		Rat	PMID:23792689\|RGD:12793033
Cellular Component	GO:0031982	vesicle	CALM2	HDA		Human	PMID:19190083
Cellular Component	GO:0031982	vesicle	Calm2	IDA		Mouse	MGI:MGI:6716978\|PMID:33199372
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Calm2	IGI	MGI:MGI:88251	Mouse	PMID:12223552
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Calm2	IGI	MGI:MGI:103249	Mouse	PMID:12223552
Biological Process	GO:0019722	calcium-mediated signaling	Calm1	IMP		Rat	PMID:20717650\|RGD:7207843
Biological Process	GO:0019722	calcium-mediated signaling	Calm2	IMP		Rat	PMID:20717650\|RGD:7207843
Biological Process	GO:0019722	calcium-mediated signaling	Calm3	IMP		Rat	PMID:20717650\|RGD:7207843
Biological Process	GO:0005513	detection of calcium ion	CALM2	IMP		Human	PMID:23040497
Biological Process	GO:0090150	establishment of protein localization to membrane	Calm1	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:0090150	establishment of protein localization to membrane	Calm2	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:0090150	establishment of protein localization to membrane	Calm3	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:0090151	establishment of protein localization to mitochondrial membrane	Calm1	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:0090151	establishment of protein localization to mitochondrial membrane	Calm2	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:0090151	establishment of protein localization to mitochondrial membrane	Calm3	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Calm2	IDA		Mouse	PMID:2469574
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	calm1a	IMP	ZFIN:ZDB-MRPHLNO-170519-1	Zfish	PMID:28148652
Biological Process	GO:1905913	negative regulation of calcium ion export across plasma membrane	Calm2	IDA		Mouse	MGI:MGI:6716978\|PMID:33199372
Biological Process	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	Calm2	IDA		Mouse	MGI:MGI:6716978\|PMID:33199372
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	CALM2	IDA		Human	PMID:26164367
Biological Process	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	CALM2	IDA		Human	PMID:8631777
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Calm1	IDA		Rat	PMID:20529840\|RGD:7241266
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Calm2	IDA		Rat	PMID:20529840\|RGD:7241266
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Calm3	IDA		Rat	PMID:20529840\|RGD:7241266
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	CALM2	IDA		Human	PMID:8631777
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	CALM2	IDA		Human	PMID:8631777
Biological Process	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	CALM2	IDA		Human	PMID:20226167
Biological Process	GO:0050848	regulation of calcium-mediated signaling	Calm2	IGI	UniProtKB:Q8CGQ8	Mouse	MGI:MGI:6716978\|PMID:33199372
Biological Process	GO:0055117	regulation of cardiac muscle contraction	CALM2	IMP		Human	PMID:23040497
Biological Process	GO:0032465	regulation of cytokinesis	CALM2	IMP		Human	PMID:16760425
Biological Process	GO:0002027	regulation of heart rate	CALM2	IMP		Human	PMID:23040497
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	Calm1	IMP		Rat	PMID:18322004\|RGD:7207845
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	Calm2	IMP		Rat	PMID:18322004\|RGD:7207845
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	Calm3	IMP		Rat	PMID:18322004\|RGD:7207845
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	CALM2	IDA		Human	PMID:20226167
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Calm1	IDA		Rat	PMID:15628869\|RGD:7241270
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Calm2	IDA		Rat	PMID:15628869\|RGD:7241270
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Calm3	IDA		Rat	PMID:15628869\|RGD:7241270
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Calm1	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Calm2	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	Calm3	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Calm1	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Calm2	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Calm3	IMP		Rat	PMID:23792689\|RGD:12793033
Biological Process	GO:0001975	response to amphetamine	Calm1	IEP		Rat	PMID:10854758\|RGD:6892957
Biological Process	GO:0001975	response to amphetamine	Calm2	IEP		Rat	PMID:10854758\|RGD:6892957
Biological Process	GO:0001975	response to amphetamine	Calm3	IEP		Rat	PMID:10854758\|RGD:6892957
Biological Process	GO:0051592	response to calcium ion	CALM2	IDA		Human	PMID:7607248
Biological Process	GO:0051412	response to corticosterone	Calm2	IEP		Rat	PMID:16503919\|RGD:6892959
Biological Process	GO:0021762	substantia nigra development	CALM2	HEP		Human	PMID:22926577

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.