Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CAPN10
  • Mouse genes Capn10
  • Rat genes Capn10
  • Zfish genes capn10
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Capn10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	CAPN10	IMP		Human	PMID:15044459
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn10	IDA		Rat	PMID:16790502|RGD:1625051
Molecular Function	GO:0008092	cytoskeletal protein binding	Capn10	IDA		Rat	PMID:17150188|RGD:1625052
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:P02545-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:P04792	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:P10636	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:Q16595	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:Q96G97-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:Q99732	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CAPN10	IPI	UniProtKB:Q9P1N4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Capn10	IPI	UniProtKB:P60881	Rat	PMID:15471947|RGD:8553339
Molecular Function	GO:0000149	SNARE binding	Capn10	IDA		Rat	PMID:15471947|RGD:8553339
Cellular Component	GO:0005938	cell cortex	Capn10	IDA		Rat	PMID:17150188|RGD:1625052
Cellular Component	GO:0005737	cytoplasm	Capn10	IDA		Rat	PMID:11375982|RGD:68750
Cellular Component	GO:0005856	cytoskeleton	Capn10	IDA		Rat	PMID:17150188|RGD:1625052
Cellular Component	GO:0005829	cytosol	CAPN10	IDA		Human	PMID:16790502
Cellular Component	GO:0005829	cytosol	Capn10	IDA		Rat	PMID:15471947|RGD:8553339
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Capn10	IDA		Rat	PMID:17150188|RGD:1625052
Cellular Component	GO:0005743	mitochondrial inner membrane	Capn10	IDA		Rat	PMID:16790502|RGD:1625051
Cellular Component	GO:0005758	mitochondrial intermembrane space	Capn10	IDA		Rat	PMID:16790502|RGD:1625051
Cellular Component	GO:0005759	mitochondrial matrix	Capn10	IDA		Rat	PMID:16790502|RGD:1625051
Cellular Component	GO:0005741	mitochondrial outer membrane	Capn10	IDA		Rat	PMID:16790502|RGD:1625051
Cellular Component	GO:0005739	mitochondrion	CAPN10	IDA		Human	PMID:16790502
Cellular Component	GO:0005634	nucleus	Capn10	IDA		Rat	PMID:11375982|RGD:68750
Cellular Component	GO:0005886	plasma membrane	Capn10	IDA		Rat	PMID:15471947|RGD:8553339
Biological Process	GO:0031532	actin cytoskeleton reorganization	Capn10	IMP		Mouse	MGI:MGI:3777524|PMID:12974673
Biological Process	GO:0031532	actin cytoskeleton reorganization	Capn10	IMP		Rat	PMID:17150188|RGD:1625052
Biological Process	GO:0007568	aging	Capn10	IDA		Rat	PMID:19144693|RGD:2317923
Biological Process	GO:0000422	autophagy of mitochondrion	Capn10	IMP		Rat	PMID:22568896|RGD:7247732
Biological Process	GO:0032869	cellular response to insulin stimulus	CAPN10	IMP		Human	PMID:17572128
Biological Process	GO:0032869	cellular response to insulin stimulus	Capn10	IMP		Mouse	MGI:MGI:3777524|PMID:12974673
Biological Process	GO:0007005	mitochondrion organization	Capn10	IMP		Rat	PMID:22568896|RGD:7247732
Biological Process	GO:0043065	positive regulation of apoptotic process	Capn10	IMP		Rat	PMID:15936930|RGD:7247737
Biological Process	GO:0046326	positive regulation of glucose import	CAPN10	IMP		Human	PMID:17572128
Biological Process	GO:0046326	positive regulation of glucose import	Capn10	IMP		Mouse	MGI:MGI:3777524|PMID:12974673
Biological Process	GO:0032024	positive regulation of insulin secretion	CAPN10	IMP		Human	PMID:15471947
Biological Process	GO:0032388	positive regulation of intracellular transport	Capn10	IMP		Mouse	MGI:MGI:3777524|PMID:12974673
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	Capn10	IMP		Mouse	PMID:15044459
Biological Process	GO:0030163	protein catabolic process	Capn10	IDA		Rat	PMID:16790502|RGD:1625051
Biological Process	GO:0006508	proteolysis	CAPN10	IMP		Human	PMID:15044459
Biological Process	GO:0009749	response to glucose	Capn10	IEP		Rat	PMID:17150188|RGD:1625052
Biological Process	GO:0031667	response to nutrient levels	Capn10	IDA		Rat	PMID:19144693|RGD:2317923
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	CAPN10	IDA		Human	PMID:15044459
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	Capn10	IMP		Mouse	MGI:MGI:3720302|PMID:15044459

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern