Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Capn3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CAPN3
- Mouse genes Capn3
- Rat genes Capn3
- Zfish genes capn3a,capn3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Capn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Capn3	IDA		Mouse	MGI:MGI:4839427\|PMID:20460380
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn3	IDA		Mouse	PMID:15138196
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	Capn3	IDA		Rat	PMID:11904300\|RGD:1600775
Molecular Function	GO:0003824	catalytic activity	CAPN3	IDA		Human	PMID:9642272
Molecular Function	GO:0019899	enzyme binding	Capn3	IPI	UniProtKB:P05064	Rat	PMID:18676612\|RGD:8554705
Molecular Function	GO:0055103	ligase regulator activity	CAPN3	IDA		Human	PMID:20694146
Molecular Function	GO:0060090	molecular adaptor activity	Capn3	IMP		Mouse	MGI:MGI:3811664\|PMID:18676612
Molecular Function	GO:0008233	peptidase activity	CAPN3	IDA		Human	PMID:23707407
Molecular Function	GO:0008233	peptidase activity	CAPN3	IDA		Human	PMID:9642272
Molecular Function	GO:0008233	peptidase activity	Capn3	IDA		Rat	PMID:14506720\|RGD:1600774
Molecular Function	GO:0008233	peptidase activity	capn3b	IDA		Zfish	PMID:30773582
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q8WZ42	Human	PMID:20860623
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q68CQ4	Human	PMID:23357851
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q8WZ42	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q8NDZ2	Human	PMID:23707407
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q9UJX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q68CQ4	Human	PMID:27657329
Molecular Function	GO:0005515	protein binding	CAPN3	IPI	UniProtKB:Q9UJX0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Capn3	IPI	UniProtKB:Q9ES46	Mouse	MGI:MGI:6383346\|PMID:19924298
Molecular Function	GO:0005515	protein binding	Capn3	IPI	PR:A2ASS6	Mouse	PMID:14741210
Molecular Function	GO:0005515	protein binding	Capn3	IPI	PR:Q9ESD7	Mouse	PMID:20405035
Molecular Function	GO:0005515	protein binding	Capn3	IPI	RefSeq:NP_035782	Mouse	PMID:15138196
Molecular Function	GO:0005515	protein binding	Capn3	IPI	RGD:3171	Rat	PMID:16938483\|RGD:1600770
Molecular Function	GO:0005102	signaling receptor binding	Capn3	IPI	UniProtKB:E9PZQ0	Rat	PMID:18676612\|RGD:8554705
Molecular Function	GO:0031402	sodium ion binding	Capn3	IDA		Mouse	MGI:MGI:4839427\|PMID:20460380
Molecular Function	GO:0008307	structural constituent of muscle	Capn3	IMP		Mouse	MGI:MGI:3811664\|PMID:18676612
Molecular Function	GO:0031432	titin binding	CAPN3	IPI	UniProtKB:Q8WZ42	Human	PMID:18310072
Molecular Function	GO:0031432	titin binding	CAPN3	IPI	UniProtKB:Q8WZ42	Human	PMID:9642272
Molecular Function	GO:0031432	titin binding	Capn3	IDA		Rat	PMID:19144634\|RGD:8553509
Cellular Component	GO:0005737	cytoplasm	CAPN3	IDA		Human	PMID:19386580
Cellular Component	GO:0005737	cytoplasm	CAPN3	IDA		Human	PMID:19556129
Cellular Component	GO:0005737	cytoplasm	Capn3	IDA		Mouse	MGI:MGI:5306294\|PMID:18073330
Cellular Component	GO:0005737	cytoplasm	Capn3	IDA		Mouse	MGI:MGI:5306562\|PMID:20139084
Cellular Component	GO:0005737	cytoplasm	Capn3	IDA		Rat	PMID:16938483\|RGD:1600770
Cellular Component	GO:0005829	cytosol	Capn3	IDA		Mouse	MGI:MGI:3811664\|PMID:18676612
Cellular Component	GO:0030016	myofibril	Capn3	IDA		Rat	PMID:19144634\|RGD:8553509
Cellular Component	GO:0005730	nucleolus	CAPN3	IDA		Human	PMID:27657329
Cellular Component	GO:0005634	nucleus	CAPN3	IDA		Human	PMID:19386580
Cellular Component	GO:0005634	nucleus	Capn3	IDA		Rat	PMID:16938483\|RGD:1600770
Cellular Component	GO:0005886	plasma membrane	Capn3	IDA		Mouse	MGI:MGI:3811664\|PMID:18676612
Cellular Component	GO:0005886	plasma membrane	Capn3	IDA		Rat	PMID:19144634\|RGD:8553509
Cellular Component	GO:0032991	protein-containing complex	Capn3	IDA		Mouse	MGI:MGI:3811664\|PMID:18676612
Cellular Component	GO:0030315	T-tubule	Capn3	IDA		Rat	PMID:19144634\|RGD:8553509
Cellular Component	GO:0030018	Z disc	Capn3	IDA		Rat	PMID:19144634\|RGD:8553509
Biological Process	GO:1990092	calcium-dependent self proteolysis	CAPN3	IDA		Human	PMID:12482600
Biological Process	GO:0071277	cellular response to calcium ion	Capn3	IDA		Mouse	MGI:MGI:4839427\|PMID:20460380
Biological Process	GO:0071472	cellular response to salt stress	Capn3	IDA		Mouse	MGI:MGI:4839427\|PMID:20460380
Biological Process	GO:0070315	G1 to G0 transition involved in cell differentiation	Capn3	IDA		Mouse	MGI:MGI:5306562\|PMID:20139084
Biological Process	GO:0061061	muscle structure development	Capn3	IMP		Mouse	MGI:MGI:3811664\|PMID:18676612
Biological Process	GO:0030239	myofibril assembly	Capn3	IMP	MGI:MGI:3046866	Mouse	PMID:15138196
Biological Process	GO:0043066	negative regulation of apoptotic process	CAPN3	IMP		Human	PMID:18073330
Biological Process	GO:0043066	negative regulation of apoptotic process	Capn3	IMP		Mouse	MGI:MGI:5306294\|PMID:18073330
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Capn3	IDA		Mouse	MGI:MGI:5306562\|PMID:20139084
Biological Process	GO:0033234	negative regulation of protein sumoylation	CAPN3	IDA		Human	PMID:20694146
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CAPN3	IMP		Human	PMID:18073330
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Capn3	IMP		Mouse	MGI:MGI:5306294\|PMID:18073330
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	CAPN3	IMP		Human	PMID:18073330
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Capn3	IMP		Mouse	MGI:MGI:5306294\|PMID:18073330
Biological Process	GO:0045862	positive regulation of proteolysis	Capn3	IDA		Mouse	MGI:MGI:5306562\|PMID:20139084
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Capn3	IMP		Mouse	MGI:MGI:3811664\|PMID:18676612
Biological Process	GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration	Capn3	IDA		Mouse	MGI:MGI:5306562\|PMID:20139084
Biological Process	GO:0012501	programmed cell death	Capn3	IDA		Mouse	MGI:MGI:4839427\|PMID:20460380
Biological Process	GO:0030163	protein catabolic process	CAPN3	IMP		Human	PMID:23357851
Biological Process	GO:0030163	protein catabolic process	CAPN3	IDA		Human	PMID:27657329
Biological Process	GO:0030163	protein catabolic process	capn3b	IMP		Zfish	PMID:30773582
Biological Process	GO:0030163	protein catabolic process	capn3b	IDA		Zfish	PMID:30773582
Biological Process	GO:0030163	protein catabolic process	capn3b	IGI	ZFIN:ZDB-GENO-100414-18,ZFIN:ZDB-MRPHLNO-130613-2	Zfish	PMID:23357851
Biological Process	GO:0031648	protein destabilization	CAPN3	IMP		Human	PMID:23357851
Biological Process	GO:0072657	protein localization to membrane	Capn3	IMP		Mouse	MGI:MGI:3811664\|PMID:18676612
Biological Process	GO:0065003	protein-containing complex assembly	Capn3	IMP		Mouse	MGI:MGI:3811664\|PMID:18676612
Biological Process	GO:0006508	proteolysis	CAPN3	IDA		Human	PMID:18310072
Biological Process	GO:0006508	proteolysis	CAPN3	IDA		Human	PMID:19386580
Biological Process	GO:0006508	proteolysis	CAPN3	IDA		Human	PMID:20694146
Biological Process	GO:0006508	proteolysis	CAPN3	IDA		Human	PMID:9642272
Biological Process	GO:0006508	proteolysis	Capn3	IDA		Mouse	MGI:MGI:4839427\|PMID:20460380
Biological Process	GO:0006508	proteolysis	Capn3	IDA		Mouse	PMID:15138196
Biological Process	GO:0006508	proteolysis	Capn3	IDA		Rat	PMID:18676612\|RGD:8554705
Biological Process	GO:0050790	regulation of catalytic activity	CAPN3	IDA		Human	PMID:20694146
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	CAPN3	IMP		Human	PMID:18073330
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	Capn3	IMP		Mouse	MGI:MGI:5306294\|PMID:18073330
Biological Process	GO:0045661	regulation of myoblast differentiation	Capn3	IDA		Mouse	MGI:MGI:5306562\|PMID:20139084
Biological Process	GO:0051592	response to calcium ion	Capn3	IDA		Rat	PMID:11904300\|RGD:1600775
Biological Process	GO:0014850	response to muscle activity	Capn3	IDA		Rat	PMID:19144634\|RGD:8553509
Biological Process	GO:0009410	response to xenobiotic stimulus	Capn3	IEP		Rat	PMID:15726428\|RGD:1600773
Biological Process	GO:0045214	sarcomere organization	Capn3	IMP	MGI:MGI:3046866	Mouse	PMID:15138196
Biological Process	GO:0097264	self proteolysis	CAPN3	IDA		Human	PMID:9642272
Biological Process	GO:0097264	self proteolysis	Capn3	IDA		Rat	PMID:18676612\|RGD:8554705
Biological Process	GO:0097264	self proteolysis	Capn3	IDA		Rat	PMID:19144634\|RGD:8553509
Biological Process	GO:1990091	sodium-dependent self proteolysis	Capn3	IDA		Rat	PMID:20460380\|RGD:7242575

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.