Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CA2
  • Mouse genes Car2
  • Rat genes Car2
  • Zfish genes ca2,cahz
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Car2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004064	arylesterase activity	CA2	IMP		Human	PMID:3126084
Molecular Function	GO:0004089	carbonate dehydratase activity	CA2	IMP		Human	PMID:7758465
Molecular Function	GO:0004089	carbonate dehydratase activity	Car2	IMP	MGI:MGI:2135646	Mouse	PMID:23881097
Molecular Function	GO:0004089	carbonate dehydratase activity	Car2	IDA		Mouse	PMID:14660577
Molecular Function	GO:0004089	carbonate dehydratase activity	Car2	IDA		Rat	PMID:6425289|RGD:1600729
Molecular Function	GO:0004089	carbonate dehydratase activity	ca2	IMP	ZFIN:ZDB-MRPHLNO-100517-6	Zfish	PMID:19915126
Molecular Function	GO:0004089	carbonate dehydratase activity	ca2	IGI	ZFIN:ZDB-MRPHLNO-100517-5,ZFIN:ZDB-MRPHLNO-100517-6	Zfish	PMID:19915126
Molecular Function	GO:0004089	carbonate dehydratase activity	cahz	IGI	ZFIN:ZDB-MRPHLNO-100517-5,ZFIN:ZDB-MRPHLNO-100517-6	Zfish	PMID:19915126
Molecular Function	GO:0004089	carbonate dehydratase activity	cahz	IMP	ZFIN:ZDB-MRPHLNO-100517-5	Zfish	PMID:19915126
Molecular Function	GO:0005515	protein binding	CA2	IPI	UniProtKB:Q9Y6M7	Human	PMID:14736710
Molecular Function	GO:0005515	protein binding	CA2	IPI	UniProtKB:Q9Y6R1	Human	PMID:15218065
Molecular Function	GO:0005515	protein binding	CA2	IPI	UniProtKB:Q9BXS9-4	Human	PMID:15990874
Molecular Function	GO:0005515	protein binding	Car2	IPI	UniProtKB:O88343	Mouse	MGI:MGI:7310187|PMID:15218065
Molecular Function	GO:0005515	protein binding	Car2	IPI	RGD:2085	Rat	PMID:10350214|RGD:1600714
Molecular Function	GO:0008270	zinc ion binding	CA2	IDA		Human	PMID:3151020
Cellular Component	GO:0045177	apical part of cell	CA2	IDA		Human	PMID:14675051
Cellular Component	GO:0045177	apical part of cell	Car2	IDA		Rat	PMID:2129509|RGD:1600727
Cellular Component	GO:0030424	axon	Car2	IDA		Rat	PMID:3110266|RGD:1600728
Cellular Component	GO:0016323	basolateral plasma membrane	Car2	IDA		Rat	PMID:16575514|RGD:1600701
Cellular Component	GO:0005737	cytoplasm	CA2	IDA		Human	PMID:114507
Cellular Component	GO:0005737	cytoplasm	CA2	IDA		Human	PMID:15990874
Cellular Component	GO:0005737	cytoplasm	Car2	IDA		Rat	PMID:102414|RGD:8553734
Cellular Component	GO:0005737	cytoplasm	Car2	IDA		Rat	PMID:16575514|RGD:1600701
Cellular Component	GO:0005829	cytosol	Car2	IDA		Mouse	MGI:MGI:3850621|PMID:15385584
Cellular Component	GO:0005829	cytosol	Car2	IDA		Mouse	PMID:23881097
Cellular Component	GO:0005829	cytosol	Car2	IDA		Mouse	PMID:24789143
Cellular Component	GO:0070062	extracellular exosome	CA2	HDA		Human	PMID:19056867
Cellular Component	GO:0005615	extracellular space	Car2	IDA		Rat	PMID:14644548|RGD:1304465
Cellular Component	GO:0005902	microvillus	Car2	IDA		Rat	PMID:16575514|RGD:1600701
Cellular Component	GO:0043209	myelin sheath	Car2	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0043209	myelin sheath	Car2	IDA		Mouse	PMID:14600151
Cellular Component	GO:0005886	plasma membrane	CA2	IDA		Human	PMID:15990874
Biological Process	GO:0038166	angiotensin-activated signaling pathway	CA2	IDA		Human	PMID:15990874
Biological Process	GO:0015670	carbon dioxide transport	Car2	IMP	MGI:MGI:2135646	Mouse	PMID:16217040
Biological Process	GO:0015670	carbon dioxide transport	ca2	IMP	ZFIN:ZDB-MRPHLNO-100517-6	Zfish	PMID:19915126
Biological Process	GO:0015670	carbon dioxide transport	ca2	IGI	ZFIN:ZDB-MRPHLNO-100517-5,ZFIN:ZDB-MRPHLNO-100517-6	Zfish	PMID:19915126
Biological Process	GO:0015670	carbon dioxide transport	cahz	IMP	ZFIN:ZDB-MRPHLNO-100517-5	Zfish	PMID:19915126
Biological Process	GO:0015670	carbon dioxide transport	cahz	IGI	ZFIN:ZDB-MRPHLNO-100517-5,ZFIN:ZDB-MRPHLNO-100517-6	Zfish	PMID:19915126
Biological Process	GO:0071498	cellular response to fluid shear stress	Car2	IEP		Rat	PMID:16777439|RGD:1600700
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ca2	IDA		Zfish	PMID:18618001
Biological Process	GO:0044849	estrous cycle	Car2	IEP		Rat	PMID:23869188|RGD:155226878
Biological Process	GO:0042539	hypotonic salinity response	ca2	IDA		Zfish	PMID:17299134
Biological Process	GO:0042539	hypotonic salinity response	cahz	IDA		Zfish	PMID:17299134
Biological Process	GO:0001822	kidney development	Car2	IEP		Rat	PMID:9655354|RGD:1600719
Biological Process	GO:0002009	morphogenesis of an epithelium	Car2	IMP	MGI:MGI:2135646	Mouse	PMID:16217040
Biological Process	GO:0070050	neuron cellular homeostasis	Car2	IMP	MGI:MGI:2135646	Mouse	PMID:23881097
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Car2	IEP		Rat	PMID:8766158|RGD:1600721
Biological Process	GO:0045780	positive regulation of bone resorption	Car2	IMP		Rat	PMID:8674544|RGD:1600722
Biological Process	GO:0032849	positive regulation of cellular pH reduction	Car2	IMP	MGI:MGI:2135646	Mouse	PMID:23881097
Biological Process	GO:0032849	positive regulation of cellular pH reduction	Car2	IMP		Rat	PMID:9665810|RGD:1342423
Biological Process	GO:2001150	positive regulation of dipeptide transmembrane transport	Car2	IMP		Mouse	MGI:MGI:4442131|PMID:20150244
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Car2	IMP		Rat	PMID:10523502|RGD:1600711
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Car2	IGI	MGI:MGI:103100	Mouse	PMID:23881097
Biological Process	GO:2001225	regulation of chloride transport	Car2	IMP	MGI:MGI:2135646	Mouse	PMID:23881097
Biological Process	GO:0051453	regulation of intracellular pH	Car2	IMP		Mouse	MGI:MGI:4442131|PMID:20150244
Biological Process	GO:0044070	regulation of monoatomic anion transport	CA2	IDA		Human	PMID:15990874
Biological Process	GO:0006885	regulation of pH	ca2	IMP	ZFIN:ZDB-MRPHLNO-080923-3	Zfish	PMID:18322140
Biological Process	GO:0043627	response to estrogen	Car2	IEP		Rat	PMID:16188437|RGD:1600703
Biological Process	GO:0010033	response to organic substance	Car2	IEP		Rat	PMID:17285311|RGD:1600699
Biological Process	GO:0009268	response to pH	Car2	IEP		Rat	PMID:8141264|RGD:1600724
Biological Process	GO:0048545	response to steroid hormone	Car2	IEP		Rat	PMID:1903702|RGD:1600726
Biological Process	GO:0010043	response to zinc ion	Car2	IEP		Rat	PMID:16140947|RGD:1600174
Biological Process	GO:0046903	secretion	Car2	IMP	MGI:MGI:2135646	Mouse	PMID:16217040
Biological Process	GO:0098719	sodium ion import across plasma membrane	ca2	IMP	ZFIN:ZDB-MRPHLNO-130611-3	Zfish	PMID:23565095
Biological Process	GO:0006814	sodium ion transport	ca2	IMP	ZFIN:ZDB-MRPHLNO-080923-3	Zfish	PMID:18322140

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern