Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cask

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CASK
- Mouse genes Cask
- Rat genes Cask
- Zfish genes caska,caskb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cask

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042043	neurexin family protein binding	Cask	IDA		Mouse	PMID:18054859
Molecular Function	GO:0042043	neurexin family protein binding	Cask	IPI	RGD:628659\|RGD:620211\|RGD:620212	Rat	PMID:8786425\|RGD:61546
Molecular Function	GO:0030165	PDZ domain binding	Cask	IPI	RGD:631330	Rat	PMID:12641734\|RGD:632479
Molecular Function	GO:0030165	PDZ domain binding	Cask	IPI	RGD:621660	Rat	PMID:15024025\|RGD:1581350
Molecular Function	GO:0030165	PDZ domain binding	Cask	IPI	RGD:62261	Rat	PMID:15024025\|RGD:1581350
Molecular Function	GO:0030165	PDZ domain binding	Cask	IPI	RGD:733316	Rat	PMID:15024025\|RGD:1581350
Molecular Function	GO:0030165	PDZ domain binding	Cask	IPI	RGD:621667	Rat	PMID:17084383\|RGD:2326120
Molecular Function	GO:0030165	PDZ domain binding	Cask	IPI	RGD:3649	Rat	PMID:9660869\|RGD:11576296
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q9Y2J0	Human	PMID:11377421
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:P41134	Human	PMID:15694377
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:O14910	Human	PMID:16688213
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q12929	Human	PMID:16688213
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q63373	Human	PMID:18423203
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q13009	Human	PMID:21763699
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q8WXD9	Human	PMID:21763699
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:O14910	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:O14910	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q9H788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q13425	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q9H788	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:O14910	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q13009	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:Q13425	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CASK	IPI	UniProtKB:P34741	Human	PMID:9660868
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q8JZS0	Mouse	PMID:18054859
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:B2RUJ5	Mouse	PMID:18054859
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:P49615	Mouse	PMID:18054859
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q99P47	Mouse	PMID:12093160
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q8BIZ1	Mouse	PMID:26085624
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q8R5M8	Mouse	PMID:12202822
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q8BSS9	Mouse	PMID:18054859
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:O55017	Mouse	PMID:18054859
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q811D0	Mouse	PMID:12351654
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q8BR86	Mouse	PMID:16874800
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:O70589	Mouse	PMID:16186258
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:P61809	Mouse	PMID:18054859
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q811D0	Mouse	PMID:16105026
Molecular Function	GO:0005515	protein binding	Cask	IPI	PR:Q8BSS9	Mouse	PMID:23791195
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:1591773	Rat	PMID:10749215\|RGD:11576295
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:3168	Rat	PMID:11356864\|RGD:1599282
Molecular Function	GO:0005515	protein binding	Cask	IPI	UniProtKB:Q8VHK2	Rat	PMID:12040031\|RGD:632380
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:1348952	Rat	PMID:12511555\|RGD:728219
Molecular Function	GO:0005515	protein binding	Cask	IPI	UniProtKB:O94868	Rat	PMID:14627983\|RGD:8554271
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:727861	Rat	PMID:15066269\|RGD:9681727
Molecular Function	GO:0005515	protein binding	Cask	IPI	UniProtKB:Q9R044	Rat	PMID:15994232\|RGD:8553727
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:3567	Rat	PMID:17084383\|RGD:2326120
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:620730	Rat	PMID:17084383\|RGD:2326120
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:620844	Rat	PMID:17084383\|RGD:2326120
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:1309923	Rat	PMID:20623620\|RGD:11100016
Molecular Function	GO:0005515	protein binding	Cask	IPI	RGD:3649	Rat	PMID:9660869\|RGD:11576296
Molecular Function	GO:0005080	protein kinase C binding	Cask	IPI	RGD:61925	Rat	PMID:17084383\|RGD:2326120
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CASK	IDA		Human	PMID:18423203
Molecular Function	GO:0044877	protein-containing complex binding	Cask	IPI	RGD:620460	Rat	PMID:15331416\|RGD:1600864
Cellular Component	GO:0097440	apical dendrite	Cask	IDA		Rat	PMID:9660869\|RGD:11576296
Cellular Component	GO:0005604	basement membrane	CASK	IDA		Human	PMID:18664494
Cellular Component	GO:0005604	basement membrane	Cask	IDA		Mouse	MGI:MGI:3810856\|PMID:18664494
Cellular Component	GO:0016323	basolateral plasma membrane	Cask	IDA		Mouse	PMID:16105026
Cellular Component	GO:0016323	basolateral plasma membrane	Cask	IDA		Mouse	PMID:12351654
Cellular Component	GO:0016323	basolateral plasma membrane	Cask	IDA		Rat	PMID:10710551\|RGD:11576304
Cellular Component	GO:0005911	cell-cell junction	CASK	IDA		Human	PMID:18664494
Cellular Component	GO:0005911	cell-cell junction	Cask	IDA		Mouse	MGI:MGI:3810856\|PMID:18664494
Cellular Component	GO:0060170	ciliary membrane	Cask	IDA		Rat	PMID:18596612\|RGD:8554451
Cellular Component	GO:0005737	cytoplasm	CASK	IDA		Human	PMID:18664494
Cellular Component	GO:0005737	cytoplasm	Cask	IDA		Mouse	MGI:MGI:3810856\|PMID:18664494
Cellular Component	GO:0005829	cytosol	Cask	IDA		Mouse	PMID:12202822
Cellular Component	GO:0030425	dendrite	Cask	IDA		Rat	PMID:12641734\|RGD:632479
Cellular Component	GO:0005925	focal adhesion	CASK	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	Cask	IDA		Mouse	PMID:18054859
Cellular Component	GO:0016020	membrane	Cask	IDA		Rat	PMID:11356864\|RGD:1599282
Cellular Component	GO:0016020	membrane	Cask	IDA		Rat	PMID:17084383\|RGD:2326120
Cellular Component	GO:0045121	membrane raft	Cask	IDA		Rat	PMID:11679592\|RGD:1599945
Cellular Component	GO:0043025	neuronal cell body	Cask	IDA		Rat	PMID:9660869\|RGD:11576296
Cellular Component	GO:0005652	nuclear lamina	CASK	IDA		Human	PMID:18664494
Cellular Component	GO:0016363	nuclear matrix	CASK	IDA		Human	PMID:18664494
Cellular Component	GO:0005730	nucleolus	CASK	IDA		Human	PMID:18664494
Cellular Component	GO:0005634	nucleus	Cask	IDA		Mouse	MGI:MGI:3810856\|PMID:18664494
Cellular Component	GO:0005634	nucleus	Cask	IDA		Rat	PMID:18664494\|RGD:8553702
Cellular Component	GO:0005634	nucleus	Cask	IDA		Rat	PMID:20623620\|RGD:11100016
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cask	IDA		Rat	PMID:12641734\|RGD:632479
Cellular Component	GO:0005886	plasma membrane	Cask	IDA		Rat	PMID:9660869\|RGD:11576296
Cellular Component	GO:0098846	podocyte foot	Cask	IDA		Rat	PMID:15994232\|RGD:8553727
Cellular Component	GO:0014069	postsynaptic density	Cask	IDA		Rat	PMID:11679592\|RGD:1599945
Cellular Component	GO:0014069	postsynaptic density	Cask	IDA		Rat	PMID:12641734\|RGD:632479
Cellular Component	GO:0042734	presynaptic membrane	Cask	IDA		Rat	PMID:18596612\|RGD:8554451
Cellular Component	GO:0032991	protein-containing complex	Cask	IDA		Rat	PMID:11356864\|RGD:1599282
Cellular Component	GO:0032991	protein-containing complex	Cask	IDA		Rat	PMID:15331416\|RGD:1600864
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Cask	IMP		Mouse	PMID:17287346
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Cask	IDA		Mouse	PMID:17287346
Cellular Component	GO:0045202	synapse	Cask	IDA		Mouse	PMID:12202822
Cellular Component	GO:0045202	synapse	Cask	IDA		Mouse	PMID:16186258
Cellular Component	GO:0045202	synapse	Cask	IDA		Mouse	PMID:14622577
Cellular Component	GO:0045202	synapse	Cask	IDA		Mouse	PMID:18054859
Cellular Component	GO:0097060	synaptic membrane	Cask	IDA		Rat	PMID:8786425\|RGD:61546
Cellular Component	GO:0097060	synaptic membrane	Cask	IDA		Rat	PMID:9660869\|RGD:11576296
Cellular Component	GO:0031982	vesicle	Cask	IDA		Mouse	MGI:MGI:3821631\|PMID:19036990
Biological Process	GO:0070509	calcium ion import	Cask	IMP		Mouse	PMID:18054859
Biological Process	GO:0021987	cerebral cortex development	Cask	IEP		Rat	PMID:10749215\|RGD:11576295
Biological Process	GO:0051649	establishment of localization in cell	Cask	IMP		Mouse	PMID:18054859
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	CASK	IMP		Human	PMID:18664494
Biological Process	GO:0090288	negative regulation of cellular response to growth factor stimulus	CASK	IMP		Human	PMID:18664494
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	CASK	IDA		Human	PMID:18664494
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	CASK	IMP		Human	PMID:18664494
Biological Process	GO:0061045	negative regulation of wound healing	CASK	IMP		Human	PMID:18664494
Biological Process	GO:0090280	positive regulation of calcium ion import	Cask	IDA		Mouse	PMID:18054859
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Cask	IMP		Rat	PMID:18606847\|RGD:11576294
Biological Process	GO:0032024	positive regulation of insulin secretion	Cask	IMP		Rat	PMID:24140090\|RGD:11576293
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Cask	IGI	MGI:MGI:107404	Mouse	PMID:15584924
Biological Process	GO:0072659	protein localization to plasma membrane	Cask	IMP		Rat	PMID:14960569\|RGD:1304295
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Cask	IDA		Mouse	PMID:17287346
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Cask	IMP		Mouse	PMID:17287346
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Cask	IDA		Rat	PMID:19275891\|RGD:11576300

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.