Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CASP12
  • Mouse genes Casp12
  • Rat genes Casp12
  • Zfish genes caspa
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casp12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp12	IDA		Mouse	MGI:MGI:5634893|PMID:12097332
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	caspa	IDA		Zfish	PMID:12464617
Molecular Function	GO:0008234	cysteine-type peptidase activity	Casp12	IDA		Rat	PMID:18316105|RGD:2311460
Molecular Function	GO:0004175	endopeptidase activity	Casp12	IDA		Rat	PMID:18332441|RGD:2311459
Molecular Function	GO:0004175	endopeptidase activity	caspa	IDA		Zfish	PMID:30150286
Molecular Function	GO:0002020	protease binding	Casp12	IDA		Rat	PMID:18332441|RGD:2311459
Molecular Function	GO:0005515	protein binding	Casp12	IPI	UniProtKB:Q12933	Mouse	MGI:MGI:5430900|PMID:11278723
Molecular Function	GO:0005515	protein binding	Casp12	IPI	PR:Q01853	Mouse	PMID:14561754
Molecular Function	GO:0005515	protein binding	Casp12	IPI	PR:P12815	Mouse	PMID:14561754
Molecular Function	GO:0005515	protein binding	Casp12	IPI	UniProtKB:O95786	Rat	PMID:20818395|RGD:8554587
Molecular Function	GO:0005515	protein binding	caspa	IPI	ZFIN:ZDB-GENE-020812-1	Zfish	PMID:29791979
Molecular Function	GO:0032090	Pyrin domain binding	caspa	IPI	ZFIN:ZDB-GENE-000511-2	Zfish	PMID:12464617
Cellular Component	GO:0061702	canonical inflammasome complex	caspa	IPI	ZFIN:ZDB-GENE-000511-2,ZFIN:ZDB-GENE-120709-59	Zfish	PMID:30150286
Cellular Component	GO:0005829	cytosol	Casp12	IDA		Rat	PMID:18316105|RGD:2311460
Cellular Component	GO:0005783	endoplasmic reticulum	CASP12	IDA		Human	PMID:10638761
Cellular Component	GO:0005783	endoplasmic reticulum	Casp12	IDA		Mouse	MGI:MGI:1351404|PMID:10638761
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Casp12	IDA		Rat	PMID:18316105|RGD:2311460
Cellular Component	GO:0072558	NLRP1 inflammasome complex	caspa	IPI		Zfish	PMID:30150286|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0072558	NLRP1 inflammasome complex	caspa	IDA		Zfish	PMID:30150286|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0005634	nucleus	Casp12	IDA		Rat	PMID:18316105|RGD:2311460
Biological Process	GO:0007568	aging	Casp12	IEP		Rat	PMID:16139996|RGD:2311469
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Casp12	IEP		Rat	PMID:29568958|RGD:34888236
Biological Process	GO:0071287	cellular response to manganese ion	Casp12	IEP		Rat	PMID:23934647|RGD:10047151
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	caspa	IMP	ZFIN:ZDB-MRPHLNO-120808-1	Zfish	PMID:12464617
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Casp12	IDA		Mouse	PMID:10882126
Biological Process	GO:0044346	fibroblast apoptotic process	Casp12	IDA		Mouse	PMID:12847083
Biological Process	GO:0045087	innate immune response	caspa	IGI	ZFIN:ZDB-MRPHLNO-180823-3	Zfish	PMID:29123523
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	Casp12	IMP		Rat	PMID:10638761|RGD:10047306
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Casp12	IMP		Mouse	MGI:MGI:1351404|PMID:10638761
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Casp12	IDA		Mouse	MGI:MGI:5634893|PMID:12097332
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Casp12	IGI	MGI:MGI:1097161	Mouse	PMID:12847083
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Casp12	IGI	MGI:MGI:99702	Mouse	PMID:12847083
Biological Process	GO:0001554	luteolysis	Casp12	IEP		Rat	PMID:25332219|RGD:13782179
Biological Process	GO:0043065	positive regulation of apoptotic process	Casp12	IMP		Rat	PMID:17083921|RGD:2311464
Biological Process	GO:0043065	positive regulation of apoptotic process	caspa	IDA		Zfish	PMID:12464617
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Casp12	IMP		Rat	PMID:17083921|RGD:2311464
Biological Process	GO:0010954	positive regulation of protein processing	caspa	IMP		Zfish	PMID:31852739
Biological Process	GO:0010954	positive regulation of protein processing	caspa	IDA		Zfish	PMID:31852739
Biological Process	GO:0010663	positive regulation of striated muscle cell apoptotic process	Casp12	IMP		Rat	PMID:26801321|RGD:11571826
Biological Process	GO:0016540	protein autoprocessing	Casp12	IDA		Rat	PMID:18332441|RGD:2311459
Biological Process	GO:0030163	protein catabolic process	Casp12	IDA		Rat	PMID:18316105|RGD:2311460
Biological Process	GO:0070269	pyroptosis	caspa	IGI	ZFIN:ZDB-GENO-210602-8	Zfish	PMID:32332700
Biological Process	GO:0034059	response to anoxia	Casp12	IEP		Rat	PMID:17083921|RGD:2311464
Biological Process	GO:0009409	response to cold	Casp12	IEP		Rat	PMID:18456407|RGD:2311457
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Casp12	IEP		Rat	PMID:16979584|RGD:2311465
Biological Process	GO:0045471	response to ethanol	Casp12	IEP		Rat	PMID:17433554|RGD:2311463
Biological Process	GO:0010035	response to inorganic substance	Casp12	IEP		Rat	PMID:18675883|RGD:2311454
Biological Process	GO:0010041	response to iron(III) ion	Casp12	IEP		Rat	PMID:19594550|RGD:2311452
Biological Process	GO:0035094	response to nicotine	Casp12	IEP		Rat	PMID:18477628|RGD:2311456
Biological Process	GO:0010243	response to organonitrogen compound	Casp12	IEP		Rat	PMID:18675883|RGD:2311454
Biological Process	GO:0009410	response to xenobiotic stimulus	Casp12	IEP		Rat	PMID:16236330|RGD:2311468
Biological Process	GO:0097264	self proteolysis	Casp12	IDA		Mouse	MGI:MGI:5634893|PMID:12097332
Biological Process	GO:0097264	self proteolysis	caspa	IDA		Zfish	PMID:31852739

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern