Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CASP2
  • Mouse genes Casp2
  • Rat genes Casp2
  • Zfish genes casp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP2	IDA		Human	PMID:10980123
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP2	IDA		Human	PMID:21726810
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP2	IDA		Human	PMID:9044836
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Casp2	IDA		Mouse	PMID:16183742
Molecular Function	GO:0042802	identical protein binding	CASP2	IPI	UniProtKB:P42575	Human	PMID:22531785
Molecular Function	GO:0042802	identical protein binding	CASP2	IPI	UniProtKB:P42575	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	CASP2	IPI	UniProtKB:P42575	Human	PMID:26871637
Molecular Function	GO:0042802	identical protein binding	CASP2	IPI	UniProtKB:P42575	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	CASP2	IPI	UniProtKB:P42575	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:Q9C000	Human	PMID:11076957
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P42575-1	Human	PMID:11156409
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:11156409
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:Q8WU39-2	Human	PMID:11350957
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:15073321
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:16652156
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:31467278
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:O43741	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:O95429	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:8985253
Molecular Function	GO:0005515	protein binding	CASP2	IPI	UniProtKB:O60936	Human	PMID:9560245
Molecular Function	GO:0005515	protein binding	Casp2	IPI	PR:P52293	Mouse	PMID:12477715
Molecular Function	GO:0005515	protein binding	Casp2	IPI	UniProtKB:Q62881	Rat	PMID:16639714|RGD:10047164
Molecular Function	GO:0019904	protein domain specific binding	CASP2	IPI	UniProtKB:P78560	Human	PMID:9044836
Cellular Component	GO:0005737	cytoplasm	Casp2	IDA		Mouse	PMID:10931486
Cellular Component	GO:1905369	endopeptidase complex	CASP2	IPI		Human	PMID:15073321
Cellular Component	GO:0016020	membrane	Casp2	IDA		Rat	PMID:16123172|RGD:4107078
Cellular Component	GO:0005739	mitochondrion	Casp2	IDA		Rat	PMID:11716979|RGD:4107083
Cellular Component	GO:0005634	nucleus	Casp2	IDA		Mouse	PMID:12477715
Biological Process	GO:0007568	aging	Casp2	IEP		Rat	PMID:12175478|RGD:4107079
Biological Process	GO:0006915	apoptotic process	Casp2	IMP		Rat	PMID:18614702|RGD:4107075
Biological Process	GO:0097190	apoptotic signaling pathway	Casp2	IDA		Mouse	PMID:16183742
Biological Process	GO:0097190	apoptotic signaling pathway	Casp2	IDA		Mouse	PMID:12477715
Biological Process	GO:0007420	brain development	Casp2	IEP		Rat	PMID:11741299|RGD:4107082
Biological Process	GO:0071260	cellular response to mechanical stimulus	CASP2	IEP		Human	PMID:19593445
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	CASP2	IMP		Human	PMID:21726810
Biological Process	GO:0035234	ectopic germ cell programmed cell death	Casp2	IGI	MGI:MGI:107700	Mouse	PMID:11536012
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Casp2	IMP	MGI:MGI:2159368	Mouse	PMID:11536012
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	casp2	IGI	ZFIN:ZDB-GENO-050428-1,ZFIN:ZDB-MRPHLNO-080804-1,ZFIN:ZDB-MRPHLNO-080808-6	Zfish	PMID:18510930
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	casp2	IGI	ZFIN:ZDB-GENO-050428-1,ZFIN:ZDB-MRPHLNO-080804-1,ZFIN:ZDB-MRPHLNO-090205-1	Zfish	PMID:18510930
Biological Process	GO:0001554	luteolysis	Casp2	IEP		Rat	PMID:16940287|RGD:4107077
Biological Process	GO:0003407	neural retina development	Casp2	IEP		Rat	PMID:9809666|RGD:4107085
Biological Process	GO:0043065	positive regulation of apoptotic process	CASP2	IDA		Human	PMID:10980123
Biological Process	GO:0043065	positive regulation of apoptotic process	Casp2	IDA		Mouse	MGI:MGI:2450211|PMID:12477715
Biological Process	GO:0043065	positive regulation of apoptotic process	casp2	IDA		Zfish	PMID:16888647
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Casp2	IGI	MGI:MGI:1889507	Mouse	PMID:16183742
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Casp2	IMP		Rat	PMID:12067235|RGD:4107080
Biological Process	GO:0016485	protein processing	CASP2	IDA		Human	PMID:9044836
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	casp2	IGI	ZFIN:ZDB-MRPHLNO-080808-6,ZFIN:ZDB-MRPHLNO-130620-1	Zfish	PMID:22956347
Biological Process	GO:0097752	regulation of DNA stability	Casp2	IDA		Mouse	MGI:MGI:5543364|PMID:22498700

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern