Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Casp4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CASP4,CASP5
- Mouse genes Casp4
- Rat genes Casp4
- Zfish genes casp23,caspa,caspb,caspbl
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070001	aspartic-type peptidase activity	caspb	IDA		Zfish	PMID:32111733
Molecular Function	GO:0050700	CARD domain binding	CASP4	IPI	UniProtKB:Q5EG05	Human	PMID:16920334
Molecular Function	GO:0140608	cysteine-type endopeptidase activator activity	caspb	IDA		Zfish	PMID:30076291
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP4	IDA		Human	PMID:15326478
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP4	IDA		Human	PMID:16920334
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP4	IDA		Human	PMID:26375003
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP4	IDA		Human	PMID:32109412
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP4	IDA		Human	PMID:34671164
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP5	IDA		Human	PMID:16920334
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp4	IDA		Mouse	MGI:MGI:6865810\|PMID:34671164
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp4	IMP		Mouse	MGI:MGI:6259277\|PMID:30392956
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp4	IDA		Mouse	MGI:MGI:6467703\|PMID:32109412
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp4	IDA		Mouse	PMID:30135078
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	caspb	IDA		Zfish	PMID:30076291
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	caspa	IDA		Zfish	PMID:12464617
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	caspb	IDA		Zfish	PMID:12464617
Molecular Function	GO:0004175	endopeptidase activity	caspb	IDA		Zfish	PMID:30150286
Molecular Function	GO:0004175	endopeptidase activity	caspa	IDA		Zfish	PMID:30150286
Molecular Function	GO:0001530	lipopolysaccharide binding	CASP4	IDA		Human	PMID:25119034
Molecular Function	GO:0001530	lipopolysaccharide binding	Casp4	IDA		Mouse	PMID:25119034
Molecular Function	GO:0001530	lipopolysaccharide binding	caspb	IDA		Zfish	PMID:30076291
Molecular Function	GO:0005515	protein binding	CASP4	IPI	UniProtKB:P08311	Human	PMID:29077095
Molecular Function	GO:0005515	protein binding	CASP4	IPI	UniProtKB:P30740	Human	PMID:30692621
Molecular Function	GO:0005515	protein binding	CASP5	IPI	UniProtKB:P30740	Human	PMID:30692621
Molecular Function	GO:0005515	protein binding	Casp4	IPI	UniProtKB:Q5SV42\|UniProtKB:Q8VHP7\|UniProtKB:Q9D154	Mouse	MGI:MGI:6294164\|PMID:30692621
Molecular Function	GO:0005515	protein binding	Casp4	IPI	RGD:735204	Rat	PMID:19416975\|RGD:5491011
Molecular Function	GO:0005515	protein binding	caspa	IPI	ZFIN:ZDB-GENE-020812-1	Zfish	PMID:29791979
Molecular Function	GO:0032090	Pyrin domain binding	caspa	IPI	ZFIN:ZDB-GENE-000511-2	Zfish	PMID:12464617
Molecular Function	GO:0097110	scaffold protein binding	Casp4	IPI	RGD:628637	Rat	PMID:19416975\|RGD:5491011
Cellular Component	GO:0061702	canonical inflammasome complex	caspa	IPI	ZFIN:ZDB-GENE-000511-2,ZFIN:ZDB-GENE-120709-59	Zfish	PMID:30150286
Cellular Component	GO:0061702	canonical inflammasome complex	caspb	IPI	ZFIN:ZDB-GENE-000511-2,ZFIN:ZDB-GENE-120709-59	Zfish	PMID:30150286
Cellular Component	GO:0005737	cytoplasm	Casp4	IDA		Mouse	PMID:16670335
Cellular Component	GO:0005829	cytosol	CASP4	IDA		Human	PMID:23661706
Cellular Component	GO:0005829	cytosol	CASP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Casp4	IDA		Mouse	PMID:16670335
Cellular Component	GO:0005783	endoplasmic reticulum	CASP4	IDA		Human	PMID:15123740
Cellular Component	GO:0005739	mitochondrion	CASP4	IDA		Human	PMID:15123740
Cellular Component	GO:0043005	neuron projection	Casp4	IDA		Rat	PMID:19401709\|RGD:5491174
Cellular Component	GO:0043025	neuronal cell body	Casp4	IDA		Rat	PMID:19401709\|RGD:5491174
Cellular Component	GO:0072558	NLRP1 inflammasome complex	CASP5	IDA		Human	PMID:12191486
Cellular Component	GO:0072558	NLRP1 inflammasome complex	caspb	IPI		Zfish	PMID:30150286\|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0072558	NLRP1 inflammasome complex	caspa	IPI		Zfish	PMID:30150286\|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0072558	NLRP1 inflammasome complex	caspa	IDA		Zfish	PMID:30150286\|ZFIN:ZDB-PUB-180829-2
Cellular Component	GO:0005886	plasma membrane	CASP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	CASP4	IDA		Human	PMID:16920334
Cellular Component	GO:0032991	protein-containing complex	Casp4	IDA		Rat	PMID:19416975\|RGD:5491011
Biological Process	GO:0140632	canonical inflammasome complex assembly	CASP4	IDA		Human	PMID:25119034
Biological Process	GO:0140632	canonical inflammasome complex assembly	CASP4	IDA		Human	PMID:31268602
Biological Process	GO:0140632	canonical inflammasome complex assembly	CASP4	IDA		Human	PMID:34671164
Biological Process	GO:0140632	canonical inflammasome complex assembly	Casp4	IMP		Mouse	MGI:MGI:6210638\|PMID:22895188
Biological Process	GO:0140632	canonical inflammasome complex assembly	Casp4	IDA		Mouse	MGI:MGI:5511082\|PMID:24031018
Biological Process	GO:0140632	canonical inflammasome complex assembly	Casp4	IDA		Mouse	MGI:MGI:5510905\|PMID:23887873
Biological Process	GO:0140632	canonical inflammasome complex assembly	Casp4	IDA		Mouse	MGI:MGI:7432483\|PMID:30589883
Biological Process	GO:1904646	cellular response to amyloid-beta	CASP4	IMP		Human	PMID:15123740
Biological Process	GO:0071260	cellular response to mechanical stimulus	CASP5	IEP		Human	PMID:19593445
Biological Process	GO:0042742	defense response to bacterium	CASP4	IDA		Human	PMID:25119034
Biological Process	GO:0042742	defense response to bacterium	Casp4	IMP		Mouse	MGI:MGI:5468357\|PMID:23348507
Biological Process	GO:0042742	defense response to bacterium	Casp4	IDA		Mouse	PMID:25119034
Biological Process	GO:0042742	defense response to bacterium	caspb	IMP		Zfish	PMID:30076291
Biological Process	GO:0042742	defense response to bacterium	caspb	IDA		Zfish	PMID:30076291
Biological Process	GO:0050830	defense response to Gram-positive bacterium	CASP4	IDA		Human	PMID:33377178
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Casp4	IDA		Mouse	MGI:MGI:6259277\|PMID:30392956
Biological Process	GO:0032497	detection of lipopolysaccharide	Casp4	IDA		Mouse	MGI:MGI:7432483\|PMID:30589883
Biological Process	GO:0032497	detection of lipopolysaccharide	Casp4	IDA		Mouse	MGI:MGI:5511082\|PMID:24031018
Biological Process	GO:0032497	detection of lipopolysaccharide	Casp4	IDA		Mouse	MGI:MGI:5510905\|PMID:23887873
Biological Process	GO:0035234	ectopic germ cell programmed cell death	Casp4	IGI	MGI:MGI:97295	Mouse	PMID:11536012
Biological Process	GO:0035234	ectopic germ cell programmed cell death	Casp4	IMP	MGI:MGI:2159366	Mouse	PMID:11536012
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	caspa	IMP	ZFIN:ZDB-MRPHLNO-120808-1	Zfish	PMID:12464617
Biological Process	GO:0045087	innate immune response	caspa	IGI	ZFIN:ZDB-MRPHLNO-180823-3	Zfish	PMID:29123523
Biological Process	GO:0032611	interleukin-1 beta production	Casp4	IGI	MGI:MGI:2653833	Mouse	PMID:22002608
Biological Process	GO:0032611	interleukin-1 beta production	Casp4	IGI	MGI:MGI:1931465	Mouse	PMID:22002608
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	CASP4	IMP		Human	PMID:15123740
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	CASP4	IMP		Human	PMID:15123740
Biological Process	GO:0010934	macrophage cytokine production	Casp4	IGI	MGI:MGI:2653833	Mouse	PMID:22002608
Biological Process	GO:0010934	macrophage cytokine production	Casp4	IGI	MGI:MGI:1931465	Mouse	PMID:22002608
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	Casp4	IDA		Mouse	PMID:30135078
Biological Process	GO:0160075	non-canonical inflammasome complex assembly	Casp4	IDA		Mouse	PMID:25119034
Biological Process	GO:0043065	positive regulation of apoptotic process	caspa	IDA		Zfish	PMID:12464617
Biological Process	GO:0043065	positive regulation of apoptotic process	caspb	IDA		Zfish	PMID:19220579
Biological Process	GO:0043065	positive regulation of apoptotic process	caspb	IDA		Zfish	PMID:12464617
Biological Process	GO:0050729	positive regulation of inflammatory response	CASP4	IDA		Human	PMID:15326478
Biological Process	GO:0050729	positive regulation of inflammatory response	CASP4	IDA		Human	PMID:26375003
Biological Process	GO:0050729	positive regulation of inflammatory response	CASP4	IDA		Human	PMID:33377178
Biological Process	GO:0050729	positive regulation of inflammatory response	CASP4	IDA		Human	PMID:34671164
Biological Process	GO:0050729	positive regulation of inflammatory response	Casp4	IMP		Mouse	MGI:MGI:5468357\|PMID:23348507
Biological Process	GO:0050729	positive regulation of inflammatory response	Casp4	IDA		Mouse	MGI:MGI:6865810\|PMID:34671164
Biological Process	GO:0050729	positive regulation of inflammatory response	Casp4	IDA		Mouse	MGI:MGI:6259277\|PMID:30392956
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Casp4	IGI	MGI:MGI:1931465	Mouse	PMID:22002608
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Casp4	IGI	MGI:MGI:2653833	Mouse	PMID:22002608
Biological Process	GO:0032741	positive regulation of interleukin-18 production	CASP4	IDA		Human	PMID:15326478
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	CASP4	IDA		Human	PMID:33377178
Biological Process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	Casp4	IDA		Mouse	MGI:MGI:6259277\|PMID:30392956
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Casp4	IGI	MGI:MGI:1931465	Mouse	PMID:22002608
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Casp4	IGI	MGI:MGI:2653833	Mouse	PMID:22002608
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Casp4	IDA		Mouse	MGI:MGI:5780643\|PMID:26173909
Biological Process	GO:0010954	positive regulation of protein processing	caspb	IDA		Zfish	PMID:31852739
Biological Process	GO:0010954	positive regulation of protein processing	caspa	IMP		Zfish	PMID:31852739
Biological Process	GO:0010954	positive regulation of protein processing	caspb	IMP		Zfish	PMID:31852739
Biological Process	GO:0010954	positive regulation of protein processing	caspa	IDA		Zfish	PMID:31852739
Biological Process	GO:0140639	positive regulation of pyroptosis	caspb	IDA		Zfish	PMID:31852739
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	CASP4	IDA		Human	PMID:16920334
Biological Process	GO:0016540	protein autoprocessing	CASP4	IDA		Human	PMID:32109412
Biological Process	GO:0016540	protein autoprocessing	CASP4	IDA		Human	PMID:34671164
Biological Process	GO:0016540	protein autoprocessing	Casp4	IDA		Mouse	MGI:MGI:6467703\|PMID:32109412
Biological Process	GO:0016540	protein autoprocessing	Casp4	IMP		Mouse	MGI:MGI:6259277\|PMID:30392956
Biological Process	GO:0051604	protein maturation	CASP4	IDA		Human	PMID:15326478
Biological Process	GO:0051604	protein maturation	CASP4	IDA		Human	PMID:25119034
Biological Process	GO:0051604	protein maturation	CASP4	IDA		Human	PMID:26375003
Biological Process	GO:0051604	protein maturation	CASP4	IDA		Human	PMID:34671164
Biological Process	GO:0051604	protein maturation	Casp4	IDA		Mouse	PMID:30135078
Biological Process	GO:0070269	pyroptosis	CASP4	IDA		Human	PMID:31268602
Biological Process	GO:0070269	pyroptosis	CASP4	IDA		Human	PMID:32109412
Biological Process	GO:0070269	pyroptosis	CASP4	IDA		Human	PMID:34671164
Biological Process	GO:0070269	pyroptosis	Casp4	IDA		Mouse	MGI:MGI:6467703\|PMID:32109412
Biological Process	GO:0070269	pyroptosis	Casp4	IDA		Mouse	MGI:MGI:7432483\|PMID:30589883
Biological Process	GO:0070269	pyroptosis	Casp4	IDA		Mouse	MGI:MGI:6201935\|PMID:30135078
Biological Process	GO:0070269	pyroptosis	Casp4	IMP		Mouse	MGI:MGI:5468357\|PMID:23348507
Biological Process	GO:0070269	pyroptosis	Casp4	IDA		Mouse	MGI:MGI:6865810\|PMID:34671164
Biological Process	GO:0070269	pyroptosis	Casp4	IMP	MGI:MGI:5468949	Mouse	PMID:22002608
Biological Process	GO:0070269	pyroptosis	caspb	IDA		Zfish	PMID:30076291
Biological Process	GO:0070269	pyroptosis	caspb	IMP		Zfish	PMID:30076291
Biological Process	GO:0070269	pyroptosis	caspb	IDA		Zfish	PMID:31852739
Biological Process	GO:0070269	pyroptosis	caspb	IMP	ZFIN:ZDB-GENO-210406-12	Zfish	PMID:32111733
Biological Process	GO:0070269	pyroptosis	caspb	IMP	ZFIN:ZDB-GENO-210406-13	Zfish	PMID:32111733
Biological Process	GO:0070269	pyroptosis	caspa	IGI	ZFIN:ZDB-GENO-210602-8	Zfish	PMID:32332700
Biological Process	GO:0050727	regulation of inflammatory response	CASP4	IDA		Human	PMID:32109412
Biological Process	GO:0050727	regulation of inflammatory response	Casp4	IDA		Mouse	MGI:MGI:6467703\|PMID:32109412
Biological Process	GO:0097264	self proteolysis	caspa	IDA		Zfish	PMID:31852739
Biological Process	GO:0097264	self proteolysis	caspb	IDA		Zfish	PMID:31852739
Biological Process	GO:0021762	substantia nigra development	CASP5	HEP		Human	PMID:22926577

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.