Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Casp8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CASP8
- Mouse genes Casp8
- Rat genes Casp8
- Zfish genes casp8
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casp8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP8	IDA		Human	PMID:16920334
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP8	IDA		Human	PMID:19240112
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP8	IDA		Human	PMID:33852854
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	CASP8	IDA		Human	PMID:35594856
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp8	IMP		Mouse	MGI:MGI:6378798\|PMID:31511692
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp8	IMP		Mouse	MGI:MGI:6401035\|PMID:31748744
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp8	IDA		Mouse	MGI:MGI:6270017\|PMID:30361383
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp8	IGI	MGI:MGI:1336166	Mouse	PMID:21368763
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp8	IDA		Mouse	PMID:15456877
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	Casp8	IDA		Rat	PMID:16493077\|RGD:4143200
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	CASP8	IDA		Human	PMID:16916640
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	CASP8	IMP		Human	PMID:21737330
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	CASP8	IDA		Human	PMID:31827280
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Casp8	IMP		Mouse	MGI:MGI:6401044\|PMID:31827281
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Casp8	IDA		Mouse	PMID:12065591
Molecular Function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	Casp8	IDA		Mouse	PMID:16183742
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	CASP8	IMP		Human	PMID:11717445
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	CASP8	IDA		Human	PMID:16916640
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	CASP8	IDA		Human	PMID:16920334
Molecular Function	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	CASP8	IMP		Human	PMID:21980415
Molecular Function	GO:0035877	death effector domain binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:11717445
Molecular Function	GO:0005123	death receptor binding	Casp8	IPI	RGD:619831	Rat	PMID:17518537\|RGD:2290177
Molecular Function	GO:0004175	endopeptidase activity	Casp8	IDA		Mouse	MGI:MGI:6472603\|PMID:32971525
Molecular Function	GO:0004175	endopeptidase activity	Casp8	IDA		Mouse	PMID:22037414
Molecular Function	GO:0004175	endopeptidase activity	Casp8	IMP		Mouse	PMID:22037414
Molecular Function	GO:0042802	identical protein binding	CASP8	IPI	UniProtKB:Q14790	Human	PMID:16169070
Molecular Function	GO:0042802	identical protein binding	CASP8	IPI	UniProtKB:Q14790	Human	PMID:17170703
Molecular Function	GO:0008233	peptidase activity	CASP8	IMP		Human	PMID:17047155
Molecular Function	GO:0008233	peptidase activity	CASP8	IDA		Human	PMID:19740745
Molecular Function	GO:0008233	peptidase activity	Casp8	IMP	MGI:MGI:3609638	Mouse	PMID:12404118
Molecular Function	GO:0008233	peptidase activity	Casp8	IDA		Mouse	PMID:11369777
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q15121	Human	PMID:10442631
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P48023	Human	PMID:12198154
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P39429	Human	PMID:12884866
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:12884866
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q61160	Human	PMID:12884866
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q99558	Human	PMID:12884866
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O15519	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P48023	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q92851	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P10636	Human	PMID:12888622
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:14612908
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q969K3	Human	PMID:15069192
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O60936	Human	PMID:15509781
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445	Human	PMID:16498403
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P48023	Human	PMID:16498403
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13418	Human	PMID:16936772
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O00220	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O15519	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O15519-1	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O15519-1	Human	PMID:17159907
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445	Human	PMID:17159907
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:17159907
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q92851	Human	PMID:17159907
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P10275	Human	PMID:17170703
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q9UKL3	Human	PMID:17245429
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q9WUF3	Human	PMID:17245429
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P50453	Human	PMID:17479112
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P29350	Human	PMID:18086677
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O60936	Human	PMID:18245485
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445	Human	PMID:18328427
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:18485876
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:18485876
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O14763	Human	PMID:18846110
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P21580	Human	PMID:19060883
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:19060883
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:19060883
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:19176810
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O00220	Human	PMID:19427028
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13618	Human	PMID:19427028
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:19524512
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:19524512
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:19524513
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O00220	Human	PMID:20103630
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:20103630
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445-1	Human	PMID:20956295
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P51572	Human	PMID:21183955
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:21458669
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:21458669
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:21525013
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:21525013
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445	Human	PMID:21625644
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445-1	Human	PMID:21713032
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O00220	Human	PMID:21785459
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:21785459
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445	Human	PMID:21803845
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:22173242
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:22173242
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q9UDY8	Human	PMID:22267217
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:22274400
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:22274400
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P48023	Human	PMID:24025841
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O15519	Human	PMID:24438025
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:25043603
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:25911380
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:25911380
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P25445-1	Human	PMID:26942442
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13546	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P04049	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P13051-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P53350	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q06787-7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q96AX1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O15519	Human	PMID:9208847
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:9208847
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:P51572	Human	PMID:9334338
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:9343261
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:Q1XBR6	Human	PMID:9343261
Molecular Function	GO:0005515	protein binding	CASP8	IPI	UniProtKB:O60936	Human	PMID:9560245
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:6362574\|PMID:31519887
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:P25446\|UniProtKB:Q9D8Y7	Mouse	MGI:MGI:3810048\|PMID:18455983
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:5698536\|PMID:26555174
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:P25446	Mouse	MGI:MGI:5002421\|PMID:21382479
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:3690188\|PMID:16469705
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:6093208\|PMID:18946037
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:6120592\|PMID:29440439
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q61160	Mouse	MGI:MGI:5566546\|PMID:24557836
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:P19091	Mouse	MGI:MGI:5508612\|PMID:17170703
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:P25446	Mouse	MGI:MGI:5508614\|PMID:17159908
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q9D1X0	Mouse	MGI:MGI:5613476\|PMID:15383280
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:P01375\|UniProtKB:Q61160	Mouse	MGI:MGI:5706670\|PMID:26649818
Molecular Function	GO:0005515	protein binding	Casp8	IPI	PR:O35732	Mouse	PMID:21368763
Molecular Function	GO:0005515	protein binding	Casp8	IPI	PR:P28033	Mouse	PMID:11684016
Molecular Function	GO:0005515	protein binding	Casp8	IPI	PR:Q8BXR6	Mouse	PMID:24113711
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q62881	Rat	PMID:12191471\|RGD:631884
Molecular Function	GO:0005515	protein binding	Casp8	IPI	UniProtKB:Q8R2E7	Rat	PMID:19001025\|RGD:8553292
Molecular Function	GO:0044877	protein-containing complex binding	Casp8	IPI	RGD:619831	Rat	PMID:17518537\|RGD:2290177
Molecular Function	GO:0097110	scaffold protein binding	CASP8	IPI	UniProtKB:Q13158	Human	PMID:21785459
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	Casp8	IPI	RGD:621237	Rat	PMID:20649583\|RGD:5130976
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CASP8	IPI	UniProtKB:Q8WZ73	Human	PMID:15069192
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	CASP8	IDA		Human	PMID:11717445
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	Casp8	IDA		Rat	PMID:16493077\|RGD:4143200
Cellular Component	GO:0044297	cell body	Casp8	IDA		Rat	PMID:18096138\|RGD:4142863
Cellular Component	GO:0005737	cytoplasm	CASP8	IDA		Human	PMID:17167422
Cellular Component	GO:0005737	cytoplasm	Casp8	IDA		Mouse	MGI:MGI:1351404\|PMID:10638761
Cellular Component	GO:0005737	cytoplasm	Casp8	IDA		Mouse	PMID:12065591
Cellular Component	GO:0005737	cytoplasm	Casp8	IDA		Rat	PMID:10197541\|RGD:734695
Cellular Component	GO:0005829	cytosol	CASP8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CASP8	IDA		Human	PMID:17167422
Cellular Component	GO:0005829	cytosol	Casp8	IDA		Rat	PMID:15036620\|RGD:2311439
Cellular Component	GO:0031264	death-inducing signaling complex	CASP8	IDA		Human	PMID:11101870
Cellular Component	GO:0031264	death-inducing signaling complex	CASP8	IDA		Human	PMID:21803845
Cellular Component	GO:0031264	death-inducing signaling complex	Casp8	IDA		Rat	PMID:17518537\|RGD:2290177
Cellular Component	GO:0045121	membrane raft	Casp8	IDA		Rat	PMID:15590916\|RGD:1624191
Cellular Component	GO:0045121	membrane raft	Casp8	IDA		Rat	PMID:17518537\|RGD:2290177
Cellular Component	GO:0005739	mitochondrion	Casp8	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043005	neuron projection	Casp8	IDA		Rat	PMID:18096138\|RGD:4142863
Cellular Component	GO:0030690	Noc1p-Noc2p complex	Casp8	IMP		Mouse	PMID:14657025
Cellular Component	GO:0005654	nucleoplasm	CASP8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Casp8	IDA		Mouse	PMID:12065591
Cellular Component	GO:0005634	nucleus	Casp8	IDA		Rat	PMID:10197541\|RGD:734695
Cellular Component	GO:0005886	plasma membrane	Casp8	IDA		Mouse	MGI:MGI:1351404\|PMID:10638761
Cellular Component	GO:0032991	protein-containing complex	CASP8	IDA		Human	PMID:22267217
Cellular Component	GO:0032991	protein-containing complex	Casp8	IDA		Rat	PMID:15590916\|RGD:1624191
Cellular Component	GO:0097342	ripoptosome	CASP8	IDA		Human	PMID:21737330
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	CASP8	IDA		Human	PMID:18387192
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	CASP8	IDA		Human	PMID:16916640
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Casp8	IDA		Mouse	PMID:12011074
Biological Process	GO:0001525	angiogenesis	Casp8	IMP		Mouse	MGI:MGI:6401035\|PMID:31748744
Biological Process	GO:0001525	angiogenesis	Casp8	IMP	MGI:MGI:3609638	Mouse	PMID:12404118
Biological Process	GO:0006915	apoptotic process	CASP8	IMP		Human	PMID:22891283
Biological Process	GO:0006915	apoptotic process	Casp8	IDA		Mouse	PMID:16183742
Biological Process	GO:0006915	apoptotic process	Casp8	IMP		Rat	PMID:11841995\|RGD:632452
Biological Process	GO:0097190	apoptotic signaling pathway	CASP8	IMP		Human	PMID:11101870
Biological Process	GO:0097190	apoptotic signaling pathway	Casp8	IDA		Mouse	PMID:16183742
Biological Process	GO:0071260	cellular response to mechanical stimulus	CASP8	IEP		Human	PMID:19593445
Biological Process	GO:0071407	cellular response to organic cyclic compound	Casp8	IEP		Rat	PMID:16987298\|RGD:7240698
Biological Process	GO:0097194	execution phase of apoptosis	CASP8	IMP		Human	PMID:21737330
Biological Process	GO:0097194	execution phase of apoptosis	Casp8	IMP		Mouse	MGI:MGI:5602911\|PMID:24813849
Biological Process	GO:0097194	execution phase of apoptosis	Casp8	IMP		Mouse	MGI:MGI:5602910\|PMID:24813850
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	CASP8	IDA		Human	PMID:21785459
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	CASP8	IDA		Human	PMID:35446120
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Casp8	IMP		Mouse	MGI:MGI:6401035\|PMID:31748744
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Casp8	IGI	MGI:MGI:104798	Mouse	PMID:22089168
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Casp8	IDA		Mouse	PMID:12065591
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Casp8	IGI	MGI:MGI:1336166	Mouse	PMID:22675671
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Casp8	IDA		Mouse	PMID:10588860
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Casp8	IGI	MGI:MGI:109324	Mouse	PMID:22675671
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Casp8	IMP	MGI:MGI:2177602,MGI:MGI:3054930	Mouse	PMID:15322156
Biological Process	GO:0007507	heart development	Casp8	IMP		Mouse	MGI:MGI:6401035\|PMID:31748744
Biological Process	GO:0007507	heart development	Casp8	IMP	MGI:MGI:3609638	Mouse	PMID:12404118
Biological Process	GO:0097284	hepatocyte apoptotic process	Casp8	IMP	MGI:MGI:2177602,MGI:MGI:3054930	Mouse	PMID:15322156
Biological Process	GO:0019051	induction by virus of host apoptotic process	casp8	IMP	ZFIN:ZDB-MRPHLNO-080808-7	Zfish	PMID:22615868
Biological Process	GO:0030225	macrophage differentiation	Casp8	IMP	MGI:MGI:2176089	Mouse	PMID:15322156
Biological Process	GO:0070266	necroptotic process	Casp8	IGI	MGI:MGI:104798	Mouse	PMID:21368763
Biological Process	GO:0070266	necroptotic process	Casp8	IGI	MGI:MGI:104798	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Casp8	IGI	MGI:MGI:2154952	Mouse	PMID:21402742
Biological Process	GO:0070266	necroptotic process	Casp8	IGI	MGI:MGI:2154952	Mouse	PMID:21368763
Biological Process	GO:0070266	necroptotic process	Casp8	IGI	MGI:MGI:1921506	Mouse	PMID:22037414
Biological Process	GO:0070266	necroptotic process	Casp8	IGI	MGI:MGI:1336166	Mouse	PMID:21368763
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	CASP8	IMP		Human	PMID:17047155
Biological Process	GO:0060546	negative regulation of necroptotic process	CASP8	IDA		Human	PMID:31827280
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IMP		Mouse	MGI:MGI:6378798\|PMID:31511692
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IMP		Mouse	MGI:MGI:6401044\|PMID:31827281
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IMP		Mouse	MGI:MGI:6401035\|PMID:31748744
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IGI	MGI:MGI:104798	Mouse	PMID:22089168
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IGI	MGI:MGI:2154952	Mouse	PMID:21402742
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IGI	MGI:MGI:2154952	Mouse	PMID:21368763
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IGI	MGI:MGI:104798	Mouse	PMID:22037414
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IGI	MGI:MGI:104798	Mouse	PMID:21368763
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IGI	MGI:MGI:1336166	Mouse	PMID:21368763
Biological Process	GO:0060546	negative regulation of necroptotic process	Casp8	IGI	MGI:MGI:1921506	Mouse	PMID:22037414
Biological Process	GO:0001841	neural tube formation	Casp8	IMP	MGI:MGI:3609638	Mouse	PMID:12404118
Biological Process	GO:0043065	positive regulation of apoptotic process	Casp8	IMP		Mouse	MGI:MGI:5602911\|PMID:24813849
Biological Process	GO:0043065	positive regulation of apoptotic process	Casp8	IMP		Mouse	MGI:MGI:5602910\|PMID:24813850
Biological Process	GO:0043065	positive regulation of apoptotic process	Casp8	IMP		Mouse	PMID:9654089
Biological Process	GO:0043065	positive regulation of apoptotic process	Casp8	IDA		Mouse	PMID:9654089
Biological Process	GO:0043065	positive regulation of apoptotic process	casp8	IDA		Zfish	PMID:17459614
Biological Process	GO:0043065	positive regulation of apoptotic process	casp8	IDA		Zfish	PMID:16888647
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Casp8	IGI	MGI:MGI:1889507	Mouse	PMID:16183742
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CASP8	IEP		Human	PMID:12761501
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CASP8	IMP		Human	PMID:12884866
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	CASP8	IMP		Human	PMID:22267217
Biological Process	GO:0045651	positive regulation of macrophage differentiation	CASP8	IMP		Human	PMID:17047155
Biological Process	GO:1901216	positive regulation of neuron death	Casp8	IMP		Rat	PMID:10197541\|RGD:734695
Biological Process	GO:0045862	positive regulation of proteolysis	CASP8	IDA		Human	PMID:18387192
Biological Process	GO:0051604	protein maturation	CASP8	IDA		Human	PMID:16916640
Biological Process	GO:0051604	protein maturation	CASP8	IDA		Human	PMID:33852854
Biological Process	GO:0051604	protein maturation	CASP8	IDA		Human	PMID:35594856
Biological Process	GO:0016485	protein processing	Casp8	IDA		Mouse	MGI:MGI:6270017\|PMID:30361383
Biological Process	GO:0016485	protein processing	Casp8	IDA		Rat	PMID:16493077\|RGD:4143200
Biological Process	GO:0006508	proteolysis	CASP8	IDA		Human	PMID:12888622
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CASP8	IMP		Human	PMID:10521396
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	Casp8	IDA		Mouse	MGI:MGI:6472603\|PMID:32971525
Biological Process	GO:0070269	pyroptosis	Casp8	IDA		Mouse	MGI:MGI:6270017\|PMID:30361383
Biological Process	GO:0070269	pyroptosis	Casp8	IMP		Mouse	MGI:MGI:6401035\|PMID:31748744
Biological Process	GO:2001233	regulation of apoptotic signaling pathway	Casp8	IGI	MGI:MGI:103223	Mouse	PMID:15456877
Biological Process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	casp8	IGI	ZFIN:ZDB-MRPHLNO-080808-7,ZFIN:ZDB-MRPHLNO-130620-1	Zfish	PMID:22956347
Biological Process	GO:0001817	regulation of cytokine production	Casp8	IDA		Mouse	MGI:MGI:6472603\|PMID:32971525
Biological Process	GO:0045088	regulation of innate immune response	Casp8	IDA		Mouse	MGI:MGI:6472603\|PMID:32971525
Biological Process	GO:0070243	regulation of thymocyte apoptotic process	Casp8	IGI	MGI:MGI:103223	Mouse	PMID:15456877
Biological Process	GO:0046677	response to antibiotic	Casp8	IEP		Rat	PMID:18595259\|RGD:2311434
Biological Process	GO:0032025	response to cobalt ion	Casp8	IEP		Rat	PMID:18598848\|RGD:2311433
Biological Process	GO:0009409	response to cold	Casp8	IEP		Rat	PMID:18410517\|RGD:2311437
Biological Process	GO:0032355	response to estradiol	Casp8	IEP		Rat	PMID:18598848\|RGD:2311433
Biological Process	GO:0045471	response to ethanol	Casp8	IDA		Rat	PMID:18269875\|RGD:2311438
Biological Process	GO:0032496	response to lipopolysaccharide	Casp8	IEP		Rat	PMID:18289516\|RGD:2293323
Biological Process	GO:0034612	response to tumor necrosis factor	CASP8	IMP		Human	PMID:10521396
Biological Process	GO:0097264	self proteolysis	Casp8	IMP		Mouse	MGI:MGI:6378798\|PMID:31511692
Biological Process	GO:0036462	TRAIL-activated apoptotic signaling pathway	CASP8	IDA		Human	PMID:21785459

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.