Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CASP8AP2
  • Mouse genes Casp8ap2
  • Rat genes Casp8ap2
  • Zfish genes casp8ap2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casp8ap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	Casp8ap2	IDA		Mouse	PMID:10235259
Molecular Function	GO:0042802	identical protein binding	Casp8ap2	IDA		Mouse	PMID:10235259
Molecular Function	GO:0002020	protease binding	Casp8ap2	IPI	UniProtKB:Q14790	Mouse	MGI:MGI:5486553|PMID:17245429
Molecular Function	GO:0005515	protein binding	CASP8AP2	IPI	UniProtKB:Q61026	Human	PMID:12477726
Molecular Function	GO:0005515	protein binding	CASP8AP2	IPI	UniProtKB:Q9Y6Q9	Human	PMID:15698540
Molecular Function	GO:0005515	protein binding	CASP8AP2	IPI	UniProtKB:P23497	Human	PMID:17245429
Molecular Function	GO:0005515	protein binding	CASP8AP2	IPI	UniProtKB:Q14790	Human	PMID:17245429
Molecular Function	GO:0005515	protein binding	CASP8AP2	IPI	UniProtKB:O75925	Human	PMID:21338522
Molecular Function	GO:0005515	protein binding	CASP8AP2	IPI	UniProtKB:O15350-1	Human	PMID:21725362
Molecular Function	GO:0005515	protein binding	Casp8ap2	IPI	UniProtKB:P25445	Mouse	PMID:10235259
Molecular Function	GO:0005515	protein binding	Casp8ap2	IPI	PR:Q61160	Mouse	PMID:10235259
Molecular Function	GO:0005515	protein binding	Casp8ap2	IPI	UniProtKB:Q14790	Mouse	PMID:10235259
Molecular Function	GO:0032184	SUMO polymer binding	CASP8AP2	IDA		Human	PMID:23086935
Molecular Function	GO:0003714	transcription corepressor activity	CASP8AP2	IDA		Human	PMID:12477726
Cellular Component	GO:0005737	cytoplasm	CASP8AP2	IDA		Human	PMID:12477726
Cellular Component	GO:0005737	cytoplasm	CASP8AP2	IDA		Human	PMID:17245429
Cellular Component	GO:0005737	cytoplasm	Casp8ap2	IDA		Rat	PMID:19721136|RGD:14397558
Cellular Component	GO:0005739	mitochondrion	CASP8AP2	IDA		Human	PMID:17245429
Cellular Component	GO:0005634	nucleus	CASP8AP2	IDA		Human	PMID:12477726
Cellular Component	GO:0005634	nucleus	Casp8ap2	IDA		Rat	PMID:19721136|RGD:14397558
Cellular Component	GO:0016605	PML body	CASP8AP2	IDA		Human	PMID:17245429
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	CASP8AP2	IMP		Human	PMID:17245429
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Casp8ap2	IDA		Mouse	PMID:10235259
Biological Process	GO:0071260	cellular response to mechanical stimulus	CASP8AP2	IEP		Human	PMID:19593445
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	CASP8AP2	IMP		Human	PMID:17245429
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Casp8ap2	IDA		Mouse	PMID:10235259
Biological Process	GO:0036337	Fas signaling pathway	CASP8AP2	IMP		Human	PMID:17245429

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern