Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CASQ1
  • Mouse genes Casq1
  • Rat genes Casq1
  • Zfish genes casq1a,casq1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casq1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	CASQ1	IDA		Human	PMID:22337878
Molecular Function	GO:0005509	calcium ion binding	CASQ1	IDA		Human	PMID:28895244
Molecular Function	GO:0005509	calcium ion binding	Casq1	IDA		Mouse	MGI:MGI:5582187|PMID:7945294
Molecular Function	GO:0005509	calcium ion binding	Casq1	IDA		Rat	PMID:19029185|RGD:2313265
Molecular Function	GO:0005509	calcium ion binding	casq1a	IDA		Zfish	PMID:26585961
Molecular Function	GO:0005509	calcium ion binding	casq1b	IDA		Zfish	PMID:26585961
Molecular Function	GO:0042802	identical protein binding	CASQ1	IDA		Human	PMID:27185316
Molecular Function	GO:0042802	identical protein binding	CASQ1	IDA		Human	PMID:28895244
Molecular Function	GO:0005515	protein binding	CASQ1	IPI	UniProtKB:Q13586	Human	PMID:27185316
Molecular Function	GO:0005515	protein binding	CASQ1	IPI	UniProtKB:Q8NHY3	Human	PMID:32296183
Cellular Component	GO:0005737	cytoplasm	Casq1	IDA		Rat	PMID:15684334|RGD:2313225
Cellular Component	GO:0005783	endoplasmic reticulum	CASQ1	IDA		Human	PMID:27185316
Cellular Component	GO:0005794	Golgi apparatus	Casq1	IDA		Rat	PMID:149586|RGD:2313260
Cellular Component	GO:0031674	I band	Casq1	IDA		Rat	PMID:15684334|RGD:2313225
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Casq1	IDA		Rat	PMID:14506614|RGD:1581765
Cellular Component	GO:0005759	mitochondrial matrix	Casq1	IDA		Mouse	MGI:MGI:5582187|PMID:7945294
Cellular Component	GO:0005739	mitochondrion	CASQ1	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Casq1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0030016	myofibril	Casq1	IDA		Rat	PMID:15684334|RGD:2313225
Cellular Component	GO:0042383	sarcolemma	Casq1	IDA		Rat	PMID:15684334|RGD:2313225
Cellular Component	GO:0016529	sarcoplasmic reticulum	Casq1	IDA		Mouse	MGI:MGI:5582187|PMID:7945294
Cellular Component	GO:0016529	sarcoplasmic reticulum	Casq1	IDA		Mouse	PMID:14728599
Cellular Component	GO:0016529	sarcoplasmic reticulum	Casq1	IDA		Mouse	PMID:12419813
Cellular Component	GO:0016529	sarcoplasmic reticulum	Casq1	IDA		Rat	PMID:19029185|RGD:2313265
Cellular Component	GO:0033018	sarcoplasmic reticulum lumen	Casq1	IDA		Mouse	MGI:MGI:5306707|PMID:22049211
Cellular Component	GO:0033018	sarcoplasmic reticulum lumen	Casq1	IDA		Mouse	PMID:16600288
Cellular Component	GO:0030315	T-tubule	Casq1	IDA		Rat	PMID:11010809|RGD:2313244
Cellular Component	GO:0014802	terminal cisterna	Casq1	IDA		Rat	PMID:11010809|RGD:2313244
Cellular Component	GO:0014804	terminal cisterna lumen	Casq1	IDA		Rat	PMID:6355123|RGD:2313258
Cellular Component	GO:0030018	Z disc	casq1a	IDA		Zfish	PMID:26585961
Cellular Component	GO:0030018	Z disc	casq1b	IDA		Zfish	PMID:26585961
Biological Process	GO:0007029	endoplasmic reticulum organization	Casq1	IMP	MGI:MGI:3530841	Mouse	PMID:17627988
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	CASQ1	IMP		Human	PMID:28895244
Biological Process	GO:1901341	positive regulation of store-operated calcium channel activity	CASQ1	IMP		Human	PMID:27185316
Biological Process	GO:1901341	positive regulation of store-operated calcium channel activity	CASQ1	IMP		Human	PMID:28895244
Biological Process	GO:0051258	protein polymerization	CASQ1	IDA		Human	PMID:22337878
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Casq1	IDA		Mouse	PMID:12419813
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Casq1	IMP	MGI:MGI:3530841	Mouse	PMID:17627988
Biological Process	GO:0051282	regulation of sequestering of calcium ion	Casq1	IDA		Rat	PMID:19029185|RGD:2313265
Biological Process	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	Casq1	IMP		Mouse	MGI:MGI:5306707|PMID:22049211
Biological Process	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	Casq1	IMP	MGI:MGI:3530841	Mouse	PMID:17627988
Biological Process	GO:2001256	regulation of store-operated calcium entry	CASQ1	IMP		Human	PMID:28895244
Biological Process	GO:0014894	response to denervation involved in regulation of muscle adaptation	Casq1	IEP		Rat	PMID:15138610|RGD:2313228
Biological Process	GO:0009408	response to heat	Casq1	IMP	MGI:MGI:3530841	Mouse	PMID:19237502
Biological Process	GO:0014870	response to muscle inactivity	Casq1	IEP		Rat	PMID:11546666|RGD:2313240
Biological Process	GO:0010033	response to organic substance	Casq1	IEP		Rat	PMID:19423840|RGD:2313202
Biological Process	GO:0045214	sarcomere organization	Casq1	IMP		Mouse	MGI:MGI:5306707|PMID:22049211
Biological Process	GO:0007519	skeletal muscle tissue development	Casq1	IEP		Rat	PMID:8600158|RGD:2313254

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern