Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CASQ2
  • Mouse genes Casq2
  • Rat genes Casq2
  • Zfish genes casq2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Casq2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	CASQ2	IDA		Human	PMID:16601229
Molecular Function	GO:0005509	calcium ion binding	CASQ2	IDA		Human	PMID:16908766
Molecular Function	GO:0005509	calcium ion binding	CASQ2	IDA		Human	PMID:17881003
Molecular Function	GO:0005509	calcium ion binding	Casq2	IMP		Mouse	MGI:MGI:3689635|PMID:16932808
Molecular Function	GO:0140314	calcium ion sequestering activity	CASQ2	IMP		Human	PMID:16908766
Molecular Function	GO:0048306	calcium-dependent protein binding	CASQ2	IDA		Human	PMID:15485681
Molecular Function	GO:0043167	ion binding	CASQ2	IDA		Human	PMID:21416293
Molecular Function	GO:0005515	protein binding	CASQ2	IPI	UniProtKB:Q8BSY0	Human	PMID:22123818
Molecular Function	GO:0005515	protein binding	CASQ2	IPI	UniProtKB:Q13895	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	Casq2	IDA		Rat	PMID:20353949|RGD:8553553
Molecular Function	GO:0005080	protein kinase C binding	Casq2	IDA		Rat	PMID:10431815|RGD:69798
Cellular Component	GO:0005737	cytoplasm	CASQ2	IDA		Human	PMID:22123818
Cellular Component	GO:0030314	junctional membrane complex	Casq2	IDA		Mouse	MGI:MGI:4453101|PMID:19920148
Cellular Component	GO:0016529	sarcoplasmic reticulum	Casq2	IDA		Rat	PMID:17569730|RGD:2314601
Cellular Component	GO:0033018	sarcoplasmic reticulum lumen	Casq2	IDA		Mouse	MGI:MGI:4453101|PMID:19920148
Cellular Component	GO:0030018	Z disc	Casq2	IDA		Mouse	PMID:19383796
Cellular Component	GO:0030018	Z disc	Casq2	IDA		Rat	PMID:11053140|RGD:8554533
Biological Process	GO:0060048	cardiac muscle contraction	CASQ2	IMP		Human	PMID:16908766
Biological Process	GO:0071313	cellular response to caffeine	CASQ2	IMP		Human	PMID:16908766
Biological Process	GO:0006874	intracellular calcium ion homeostasis	CASQ2	IMP		Human	PMID:16908766
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	Casq2	IDA		Mouse	MGI:MGI:5430859|PMID:21063088
Biological Process	GO:0043267	negative regulation of potassium ion transport	Casq2	IDA		Mouse	MGI:MGI:5430859|PMID:21063088
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	CASQ2	IDA		Human	PMID:16601229
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	Casq2	IMP		Rat	PMID:17569730|RGD:2314601
Biological Process	GO:0051258	protein polymerization	CASQ2	IDA		Human	PMID:17881003
Biological Process	GO:0051258	protein polymerization	CASQ2	IDA		Human	PMID:22123818
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Casq2	IMP		Rat	PMID:17569730|RGD:2314601
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	CASQ2	IMP		Human	PMID:16601229
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	CASQ2	IMP		Human	PMID:16908766
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Casq2	IMP		Mouse	MGI:MGI:3689635|PMID:16932808
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Casq2	IDA		Mouse	PMID:9525981
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Casq2	IMP		Rat	PMID:17569730|RGD:2314601
Biological Process	GO:0010649	regulation of cell communication by electrical coupling	CASQ2	IMP		Human	PMID:16908766
Biological Process	GO:0002027	regulation of heart rate	CASQ2	IMP		Human	PMID:15485681
Biological Process	GO:0002027	regulation of heart rate	CASQ2	IMP		Human	PMID:16601229
Biological Process	GO:0002027	regulation of heart rate	CASQ2	IMP		Human	PMID:16908766
Biological Process	GO:0002027	regulation of heart rate	Casq2	IMP		Mouse	MGI:MGI:3689635|PMID:16932808
Biological Process	GO:0060306	regulation of membrane repolarization	Casq2	IDA		Mouse	MGI:MGI:5430859|PMID:21063088
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Casq2	IMP		Mouse	MGI:MGI:3689635|PMID:16932808
Biological Process	GO:0045214	sarcomere organization	Casq2	IMP		Mouse	MGI:MGI:4453101|PMID:19920148
Biological Process	GO:0051208	sequestering of calcium ion	CASQ2	IDA		Human	PMID:16601229
Biological Process	GO:0051238	sequestering of metal ion	CASQ2	IDA		Human	PMID:21416293

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern