Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CAST
  • Mouse genes Cast
  • Rat genes Cast
  • Zfish genes cast
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cast

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	CAST	HDA		Human	PMID:25468996
Molecular Function	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity	CAST	IMP		Human	PMID:2407243
Molecular Function	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity	Cast	IDA		Rat	PMID:17429681|RGD:1626249
Molecular Function	GO:0002020	protease binding	Cast	IDA		Rat	PMID:19020622|RGD:5683624
Molecular Function	GO:0005515	protein binding	CAST	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	CAST	IPI	UniProtKB:O35505	Human	PMID:24462690
Molecular Function	GO:0005515	protein binding	Cast	IPI	UniProtKB:Q07009	Rat	PMID:17543955|RGD:8553978
Molecular Function	GO:0005515	protein binding	Cast	IPI	UniProtKB:Q07009	Rat	PMID:19020622|RGD:5683624
Molecular Function	GO:0005515	protein binding	Cast	IPI	UniProtKB:Q07009	Rat	PMID:19020623|RGD:11531696
Molecular Function	GO:0003723	RNA binding	CAST	HDA		Human	PMID:22658674
Cellular Component	GO:0005737	cytoplasm	Cast	IDA		Rat	PMID:20393603|RGD:5509807
Cellular Component	GO:0005829	cytosol	CAST	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CAST	IDA		Human	PMID:14559243
Cellular Component	GO:0005783	endoplasmic reticulum	CAST	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	CAST	IDA		Human	PMID:14559243
Cellular Component	GO:0016020	membrane	Cast	IDA		Mouse	PMID:11090425
Cellular Component	GO:0016020	membrane	Cast	IDA		Rat	PMID:20393603|RGD:5509807
Cellular Component	GO:0016020	membrane	Cast	IDA		Rat	PMID:27626661|RGD:13601985
Cellular Component	GO:0005634	nucleus	Cast	IDA		Rat	PMID:20393603|RGD:5509807
Cellular Component	GO:0014069	postsynaptic density	Cast	IDA		Rat	PMID:27626661|RGD:13601985
Biological Process	GO:0007568	aging	Cast	IEP		Rat	PMID:15453993|RGD:5509820
Biological Process	GO:0031100	animal organ regeneration	Cast	IEP		Rat	PMID:16871587|RGD:5683869
Biological Process	GO:0007420	brain development	Cast	IEP		Rat	PMID:19751724|RGD:5509802
Biological Process	GO:0007343	egg activation	Cast	IDA		Rat	PMID:16388007|RGD:5683870
Biological Process	GO:0097340	inhibition of cysteine-type endopeptidase activity	CAST	IMP		Human	PMID:2407243
Biological Process	GO:0001889	liver development	Cast	IEP		Rat	PMID:16871587|RGD:5683869
Biological Process	GO:0045445	myoblast differentiation	Cast	IEP		Rat	PMID:16997608|RGD:5683868
Biological Process	GO:0007520	myoblast fusion	Cast	IEP		Rat	PMID:12832042|RGD:1298731
Biological Process	GO:0043086	negative regulation of catalytic activity	Cast	IDA		Rat	PMID:17429681|RGD:1626249
Biological Process	GO:0010466	negative regulation of peptidase activity	Cast	IGI	MGI:MGI:88264	Mouse	PMID:21849499
Biological Process	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	CAST	IDA		Human	PMID:15044459
Biological Process	GO:0051726	regulation of cell cycle	Cast	IMP		Rat	PMID:18809371|RGD:5683637

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern