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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cav3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cav3
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0043014alpha-tubulin bindingCav3IDAMousePMID:14517320
Molecular FunctionGO:0005246calcium channel regulator activityCAV3IDAHumanPMID:21084288
Molecular FunctionGO:0071253connexin bindingCAV3IDAHumanPMID:19544087
Molecular FunctionGO:0071253connexin bindingCav3IPIUniProtKB:P23242MouseMGI:MGI:5448532|PMID:19544087
Molecular FunctionGO:0019899enzyme bindingCav3IPIRGD:620349RatPMID:16479074|RGD:1600265
Molecular FunctionGO:0060090molecular adaptor activityCAV3IPIUniProtKB:Q14524HumanPMID:17060380
Molecular FunctionGO:0060090molecular adaptor activityCav3IDARatPMID:15961389|RGD:1598749
Molecular FunctionGO:0050998nitric-oxide synthase bindingCav3IPIRGD:3186RatPMID:15007069|RGD:7794688
Molecular FunctionGO:0050998nitric-oxide synthase bindingCav3IPIRGD:3186RatPMID:17123860|RGD:1625028
Molecular FunctionGO:0019870potassium channel inhibitor activityCav3IMPRatPMID:22879586|RGD:8553349
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q14118HumanPMID:10988290
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q6NZI2HumanPMID:19726876
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:O95810|UniProtKB:Q6NZI2HumanPMID:24567387
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q5BKX8HumanPMID:24567387
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:P0DOE7HumanPMID:25556234
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q5BKX8HumanPMID:26497963
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q6NZI2HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q8N0V3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q96AL5HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingCAV3IPIUniProtKB:Q8NE08HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingCav3IPIUniProtKB:P18762|UniProtKB:Q01815MouseMGI:MGI:3628972|PMID:16648270
Molecular FunctionGO:0005515protein bindingCav3IPIUniProtKB:Q01815MouseMGI:MGI:6189492|PMID:24952909
Molecular FunctionGO:0005515protein bindingCav3IPIUniProtKB:Q9ES83MouseMGI:MGI:5550350|PMID:24066022
Molecular FunctionGO:0005515protein bindingCav3IPIUniProtKB:Q5SUG4MouseMGI:MGI:4888455|PMID:21084288
Molecular FunctionGO:0005515protein bindingCav3IPIUniProtKB:Q6PE92MouseMGI:MGI:4888455|PMID:21084288
Molecular FunctionGO:0005515protein bindingCav3IPIPR:Q61762MousePMID:15277200
Molecular FunctionGO:0005515protein bindingCav3IPIPR:P11531MousePMID:8663016
Molecular FunctionGO:0005515protein bindingCav3IPIPR:P05480MousePMID:14600260
Molecular FunctionGO:0005515protein bindingCav3IPIPR:Q9ET78MousePMID:15541368
Molecular FunctionGO:0005515protein bindingCav3IPIPR:Q9ESD7MousePMID:19380584
Molecular FunctionGO:0005515protein bindingCav3IPIPR:P15208MousePMID:16455755
Molecular FunctionGO:0005515protein bindingCav3IPIPR:P51637MousePMID:10988290
Molecular FunctionGO:0005515protein bindingCav3IPIPR:Q9ESD7MousePMID:20405035
Molecular FunctionGO:0005515protein bindingCav3IPIPR:Q811D0MousePMID:15277200
Molecular FunctionGO:0005515protein bindingCav3IPIUniProtKB:P51638MousePMID:10988290
Molecular FunctionGO:0005515protein bindingCav3IPIPR:Q1XH17MousePMID:19380584
Molecular FunctionGO:0005515protein bindingCav3IPIRGD:620348RatPMID:12649076|RGD:1299267
Molecular FunctionGO:0005515protein bindingCav3IPIRGD:1593550RatPMID:17069850|RGD:1599530
Molecular FunctionGO:0005515protein bindingCav3IPIRGD:2711RatPMID:17277024|RGD:1600213
Molecular FunctionGO:0005515protein bindingCav3IPIRGD:2048|RGD:69247RatPMID:19181933|RGD:7297041
Molecular FunctionGO:0005515protein bindingCav3IPIRGD:3959RatPMID:20015453|RGD:4889912
Molecular FunctionGO:0005515protein bindingCav3IPIRGD:69412RatPMID:20224290|RGD:6902941
Molecular FunctionGO:0005515protein bindingCav3IPIRGD:69247RatPMID:20332621|RGD:7296942
Molecular FunctionGO:0044877protein-containing complex bindingCAV3IDAHumanPMID:10988290
Molecular FunctionGO:0017080sodium channel regulator activityCAV3IDAHumanPMID:17060380
Molecular FunctionGO:0017080sodium channel regulator activityCAV3IMPHumanPMID:17275750
Molecular FunctionGO:0044325transmembrane transporter bindingCAV3IPIUniProtKB:Q14524HumanPMID:17060380
Molecular FunctionGO:0044325transmembrane transporter bindingCAV3IPIUniProtKB:O43497HumanPMID:21084288
Molecular FunctionGO:0044325transmembrane transporter bindingCAV3IPIUniProtKB:O95180HumanPMID:21084288
Molecular FunctionGO:0044325transmembrane transporter bindingCav3IPIMGI:MGI:1201678MousePMID:21084288
Molecular FunctionGO:0044325transmembrane transporter bindingCav3IPIPR:O88427MousePMID:21084288
Molecular FunctionGO:0044325transmembrane transporter bindingCav3IPIMGI:MGI:1298209MousePMID:19238754
Molecular FunctionGO:0044325transmembrane transporter bindingCav3IPIUniProtKB:O08962RatPMID:22879586|RGD:8553349
Cellular ComponentGO:0005901caveolaCav3IDAMouseMGI:MGI:5550350|PMID:24066022
Cellular ComponentGO:0005901caveolaCav3IDAMouseMGI:MGI:5613473|PMID:19800018
Cellular ComponentGO:0005901caveolaCav3IDAMousePMID:9008709
Cellular ComponentGO:0005901caveolaCav3IDAMousePMID:12138167
Cellular ComponentGO:0005901caveolaCav3IDAMousePMID:21084288
Cellular ComponentGO:0005901caveolaCav3IDAMousePMID:15155732
Cellular ComponentGO:0005901caveolaCav3IDAMousePMID:16648270
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:16479074|RGD:1600265
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:16497156|RGD:1599532
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:11884374|RGD:8553403
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:16135403|RGD:1599539
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:16480946|RGD:1582162
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:16624992|RGD:2302992
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:17982011|RGD:8554071
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:18054955|RGD:8554773
Cellular ComponentGO:0005901caveolaCav3IDARatPMID:9925767|RGD:8553487
Cellular ComponentGO:0009986cell surfaceCav3IDARatPMID:12649076|RGD:1299267
Cellular ComponentGO:0005737cytoplasmCav3IDARatPMID:12649076|RGD:1299267
Cellular ComponentGO:0016010dystrophin-associated glycoprotein complexCAV3IDAHumanPMID:10988290
Cellular ComponentGO:0005783endoplasmic reticulumCAV3IDAHumanPMID:22792322
Cellular ComponentGO:0014704intercalated discCav3IDARatPMID:15961389|RGD:1598749
Cellular ComponentGO:0043231intracellular membrane-bounded organelleCAV3IDAHumanGO_REF:0000052
Cellular ComponentGO:0016020membraneCav3IDAMousePMID:15541368
Cellular ComponentGO:0016020membraneCav3IDAMousePMID:10835421
Cellular ComponentGO:0016020membraneCav3IDAMousePMID:21296051
Cellular ComponentGO:0045121membrane raftCav3IDAMousePMID:11259414
Cellular ComponentGO:0031594neuromuscular junctionCav3IDARatPMID:12923236|RGD:1600290
Cellular ComponentGO:0005886plasma membraneCAV3IDAHumanGO_REF:0000052
Cellular ComponentGO:0005886plasma membraneCAV3IDAHumanPMID:17060380
Cellular ComponentGO:0005886plasma membraneCAV3IDAHumanPMID:20472890
Cellular ComponentGO:0005886plasma membraneCav3IDAMouseMGI:MGI:5763521|PMID:26497963
Cellular ComponentGO:0005886plasma membraneCav3IDAMousePMID:17200204
Cellular ComponentGO:0005886plasma membraneCav3IDAMousePMID:15277200
Cellular ComponentGO:0005886plasma membraneCav3IDAMousePMID:17164264
Cellular ComponentGO:0005886plasma membraneCav3IDAMousePMID:14600260
Cellular ComponentGO:0005886plasma membraneCav3IDARatPMID:10988290|RGD:8554249
Cellular ComponentGO:0005886plasma membraneCav3IDARatPMID:26497963|RGD:11061021
Cellular ComponentGO:0005886plasma membraneCav3IDARatPMID:9925767|RGD:8553487
Cellular ComponentGO:0032991protein-containing complexCav3IDARatPMID:12649076|RGD:1299267
Cellular ComponentGO:0032991protein-containing complexCav3IDARatPMID:16479074|RGD:1600265
Cellular ComponentGO:0042383sarcolemmaCAV3IDAHumanPMID:12847114
Cellular ComponentGO:0042383sarcolemmaCAV3IDAHumanPMID:17060380
Cellular ComponentGO:0042383sarcolemmaCav3IDAMouseMGI:MGI:5550350|PMID:24066022
Cellular ComponentGO:0042383sarcolemmaCav3IDAMousePMID:21084288
Cellular ComponentGO:0042383sarcolemmaCav3IDAMousePMID:16455755
Cellular ComponentGO:0042383sarcolemmaCav3IDAMousePMID:11115849
Cellular ComponentGO:0042383sarcolemmaCav3IDAMousePMID:16319126
Cellular ComponentGO:0042383sarcolemmaCav3IDAMousePMID:8663016
Cellular ComponentGO:0042383sarcolemmaCav3IDAMousePMID:12138167
Cellular ComponentGO:0042383sarcolemmaCav3IDAMousePMID:9008709
Cellular ComponentGO:0042383sarcolemmaCav3IDARatPMID:15961389|RGD:1598749
Cellular ComponentGO:0042383sarcolemmaCav3IDARatPMID:16501018|RGD:1599531
Cellular ComponentGO:0042383sarcolemmacav3IDAZfishPMID:15888488
Cellular ComponentGO:0030315T-tubuleCav3IDAMousePMID:9008709
Cellular ComponentGO:0030315T-tubuleCav3IDAMousePMID:16319126
Cellular ComponentGO:0030315T-tubuleCav3IDARatPMID:16501018|RGD:1599531
Cellular ComponentGO:0030315T-tubuleCav3IDARatPMID:9925767|RGD:8553487
Cellular ComponentGO:0031982vesicleCav3IDARatPMID:11884374|RGD:8553403
Cellular ComponentGO:0030018Z discCav3IDARatPMID:15980179|RGD:1600288
Biological ProcessGO:0007015actin filament organizationCav3IMPMGI:MGI:2180558MousePMID:14517320
Biological ProcessGO:0006816calcium ion transportCav3IMPMousePMID:21084288
Biological ProcessGO:0055013cardiac muscle cell developmentCav3IMPMGI:MGI:2684578MousePMID:19535499
Biological ProcessGO:0003300cardiac muscle hypertrophyCav3IMPMGI:MGI:2180558MousePMID:18552160
Biological ProcessGO:0070836caveola assemblyCAV3IDAHumanPMID:18936328
Biological ProcessGO:0070836caveola assemblyCav3IMPMGI:MGI:2684578MousePMID:18054955
Biological ProcessGO:0030154cell differentiationCav3IEPRatPMID:16135403|RGD:1599539
Biological ProcessGO:0071417cellular response to organonitrogen compoundCav3IEPRatPMID:15725944|RGD:1599540
Biological ProcessGO:0042632cholesterol homeostasisCav3IMPMGI:MGI:2684578MousePMID:15314230
Biological ProcessGO:0031122cytoplasmic microtubule organizationCav3IMPMGI:MGI:2180558MousePMID:14517320
Biological ProcessGO:0035995detection of muscle stretchCav3IMPMouseMGI:MGI:5613732|PMID:25257915
Biological ProcessGO:0006897endocytosisCav3IMPMousePMID:14600260
Biological ProcessGO:0051649establishment of localization in cellCav3IMPMousePMID:21084288
Biological ProcessGO:0051649establishment of localization in cellCav3IMPMousePMID:14600260
Biological ProcessGO:0042593glucose homeostasisCav3IMPMGI:MGI:2684578MousePMID:15314230
Biological ProcessGO:0060347heart trabecula formationCav3IMPMGI:MGI:2684578MousePMID:19535499
Biological ProcessGO:0000165MAPK cascadeCav3IMPMGI:MGI:2180558MousePMID:12138167
Biological ProcessGO:0031579membrane raft organizationCav3IMPMGI:MGI:2180558MousePMID:11259414
Biological ProcessGO:0031579membrane raft organizationCav3IMPMousePMID:14600260
Biological ProcessGO:0042693muscle cell fate commitmentcav3IMPZFIN:ZDB-MRPHLNO-050801-2ZfishPMID:15888488
Biological ProcessGO:0042693muscle cell fate commitmentcav3IMPZFIN:ZDB-MRPHLNO-050801-1ZfishPMID:15888488
Biological ProcessGO:0007520myoblast fusionCav3IMPMGI:MGI:2180558MousePMID:14517320
Biological ProcessGO:0007520myoblast fusioncav3IMPZFIN:ZDB-MRPHLNO-050801-1ZfishPMID:15888488
Biological ProcessGO:0014902myotube differentiationCav3IMPMGI:MGI:2180558MousePMID:14517320
Biological ProcessGO:0014902myotube differentiationCav3IMPMousePMID:21182936
Biological ProcessGO:0051926negative regulation of calcium ion transportCAV3IDAHumanPMID:21084288
Biological ProcessGO:0051926negative regulation of calcium ion transportCav3IMPMousePMID:21084288
Biological ProcessGO:0010614negative regulation of cardiac muscle hypertrophyCAV3IMPHumanPMID:12847114
Biological ProcessGO:0010614negative regulation of cardiac muscle hypertrophyCav3IMPMGI:MGI:2180558MousePMID:18552160
Biological ProcessGO:0061052negative regulation of cell growth involved in cardiac muscle cell developmentCav3IMPRatPMID:21170593|RGD:6784534
Biological ProcessGO:0045792negative regulation of cell sizeCAV3IMPHumanPMID:12847114
Biological ProcessGO:0043407negative regulation of MAP kinase activityCAV3IMPHumanPMID:12847114
Biological ProcessGO:0043409negative regulation of MAPK cascadeCav3IMPMGI:MGI:2180558MousePMID:12138167
Biological ProcessGO:1900826negative regulation of membrane depolarization during cardiac muscle cell action potentialCav3IMPMouseMGI:MGI:5613732|PMID:25257915
Biological ProcessGO:0051001negative regulation of nitric-oxide synthase activityCav3IMPMGI:MGI:2180562MousePMID:11159934
Biological ProcessGO:1901380negative regulation of potassium ion transmembrane transportCav3IMPRatPMID:22879586|RGD:8553349
Biological ProcessGO:1901017negative regulation of potassium ion transmembrane transporter activityCav3IMPRatPMID:22879586|RGD:8553349
Biological ProcessGO:0006469negative regulation of protein kinase activityCav3IMPMousePMID:14600260
Biological ProcessGO:0060299negative regulation of sarcomere organizationCAV3IMPHumanPMID:12847114
Biological ProcessGO:0060035notochord cell developmentcav3IGIZFIN:ZDB-MRPHLNO-050801-1,ZFIN:ZDB-MRPHLNO-070321-1ZfishPMID:17550965
Biological ProcessGO:0051647nucleus localizationCav3IMPMGI:MGI:2684578MousePMID:19535499
Biological ProcessGO:0007009plasma membrane organizationCav3IMPMGI:MGI:2180558MousePMID:12138167
Biological ProcessGO:0007009plasma membrane organizationCav3IMPMousePMID:14600260
Biological ProcessGO:0007009plasma membrane organizationCav3IMPMGI:MGI:2684578MousePMID:11115849
Biological ProcessGO:0001778plasma membrane repairCav3IMPMousePMID:19380584
Biological ProcessGO:2001288positive regulation of caveolin-mediated endocytosisCav3IMPRatPMID:22879586|RGD:8553349
Biological ProcessGO:0008284positive regulation of cell population proliferationCav3IMPRatPMID:21508095|RGD:6784533
Biological ProcessGO:0007204positive regulation of cytosolic calcium ion concentrationCav3IMPRatPMID:16318846|RGD:1599533
Biological ProcessGO:0031116positive regulation of microtubule polymerizationCav3IMPRatPMID:16480946|RGD:1582162
Biological ProcessGO:0010831positive regulation of myotube differentiationCav3IMPMGI:MGI:2180558MousePMID:14517320
Biological ProcessGO:0008104protein localizationCav3IGIMGI:MGI:107231MousePMID:15277200
Biological ProcessGO:0008104protein localizationCav3IMPMousePMID:16319126
Biological ProcessGO:0008104protein localizationCav3IMPMGI:MGI:2180558MousePMID:11259414
Biological ProcessGO:0008104protein localizationCav3IMPMGI:MGI:2180558MousePMID:12138167
Biological ProcessGO:0008104protein localizationCav3IMPMousePMID:14600260
Biological ProcessGO:0072659protein localization to plasma membraneCav3IMPMousePMID:19380584
Biological ProcessGO:0072659protein localization to plasma membraneCav3IMPMousePMID:16455755
Biological ProcessGO:0060762regulation of branching involved in mammary gland duct morphogenesisCav3IMPMGI:MGI:2180558MousePMID:19164602
Biological ProcessGO:0090279regulation of calcium ion importCAV3IDAHumanPMID:21084288
Biological ProcessGO:1901019regulation of calcium ion transmembrane transporter activityCAV3IDAHumanPMID:21084288
Biological ProcessGO:0051924regulation of calcium ion transportCav3IMPMousePMID:16648270
Biological ProcessGO:0098909regulation of cardiac muscle cell action potential involved in regulation of contractionCAV3IMPHumanPMID:17060380
Biological ProcessGO:0055117regulation of cardiac muscle contractionCAV3IMPHumanPMID:17275750
Biological ProcessGO:0008016regulation of heart contractionCav3IMPRatPMID:16318846|RGD:1599533
Biological ProcessGO:0002027regulation of heart rateCAV3IMPHumanPMID:17060380
Biological ProcessGO:1900825regulation of membrane depolarization during cardiac muscle cell action potentialCAV3IMPHumanPMID:17275750
Biological ProcessGO:0042391regulation of membrane potentialCAV3IDAHumanPMID:21084288
Biological ProcessGO:0042391regulation of membrane potentialCav3IGIMGI:MGI:96662MousePMID:15277200
Biological ProcessGO:0042391regulation of membrane potentialCav3IGIMGI:MGI:107231MousePMID:15277200
Biological ProcessGO:0051394regulation of nerve growth factor receptor activityCAV3IMPHumanPMID:20472890
Biological ProcessGO:1900744regulation of p38MAPK cascadeCav3IMPMousePMID:21182936
Biological ProcessGO:0051896regulation of protein kinase B signalingCav3IMPMousePMID:21182936
Biological ProcessGO:0038009regulation of signal transduction by receptor internalizationCAV3IMPHumanPMID:20472890
Biological ProcessGO:0014819regulation of skeletal muscle contractionCAV3IMPHumanPMID:17524427
Biological ProcessGO:2000649regulation of sodium ion transmembrane transporter activityCAV3IDAHumanPMID:17060380
Biological ProcessGO:2000649regulation of sodium ion transmembrane transporter activityCAV3IDAHumanPMID:17275750
Biological ProcessGO:0017015regulation of transforming growth factor beta receptor signaling pathwayCav3IMPMousePMID:21182936
Biological ProcessGO:0060373regulation of ventricular cardiac muscle cell membrane depolarizationCAV3IDAHumanPMID:17060380
Biological ProcessGO:0060307regulation of ventricular cardiac muscle cell membrane repolarizationCAV3IMPHumanPMID:17060380
Biological ProcessGO:0001666response to hypoxiaCav3IEPRatPMID:29438664|RGD:126925221
Biological ProcessGO:0002931response to ischemiaCav3IEPRatPMID:29438664|RGD:126925221
Biological ProcessGO:0045214sarcomere organizationcav3IMPZFIN:ZDB-MRPHLNO-050801-1ZfishPMID:15888488
Biological ProcessGO:0006641triglyceride metabolic processCav3IMPMGI:MGI:2684578MousePMID:15314230
Biological ProcessGO:0086005ventricular cardiac muscle cell action potentialCav3IMPRatPMID:22879586|RGD:8553349

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory