Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CBL
  • Mouse genes Cbl
  • Rat genes Cbl
  • Zfish genes cbl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cbl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	CBL	HDA		Human	PMID:25468996
Molecular Function	GO:0046875	ephrin receptor binding	CBL	IPI	UniProtKB:P54762	Human	PMID:18034775
Molecular Function	GO:0046875	ephrin receptor binding	Cbl	IPI	UniProtKB:Q8CBF3	Mouse	MGI:MGI:5294293|PMID:18034775
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Cbl	IDA		Rat	PMID:18773943|RGD:4108486
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Cbl	IDA		Rat	PMID:9259313|RGD:11038829
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q9Y2R2	Human	PMID:10068674
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P08631-2	Human	PMID:10092522
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:10679202
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P31946	Human	PMID:11157475
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27348	Human	PMID:11697890
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P31946	Human	PMID:11697890
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q04917	Human	PMID:11697890
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q9H6Q3	Human	PMID:11891219
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:12177062
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O43597	Human	PMID:12815057
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:14596919
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:15090612
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27348	Human	PMID:15094368
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96JA1	Human	PMID:15282549
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:15657067
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P55085	Human	PMID:15708858
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O14492	Human	PMID:15737992
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O43597	Human	PMID:15962011
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:15962011
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:15962011
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q14155	Human	PMID:16407834
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:16407834
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P08487	Human	PMID:16467851
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P12931	Human	PMID:16636290
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O43597	Human	PMID:16893902
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:16914641
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q15811	Human	PMID:16914641
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27986	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P45983	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46109	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q9Y5K6	Human	PMID:17020880
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P12931	Human	PMID:17094785
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:17094785
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P12931	Human	PMID:17141222
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:F1SDV6	Human	PMID:17372230
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q8IZP0-2	Human	PMID:17395426
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O43597	Human	PMID:17974561
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O14492	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O43597	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P08581	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P12931	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P17948	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P43405	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q9C004	Human	PMID:18273061
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q15811	Human	PMID:18654987
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:19268472
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O00459	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27986	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46108	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:20308550
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:20562913
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:20711168
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P08581	Human	PMID:21163258
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P04629	Human	PMID:21570973
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P43403	Human	PMID:22266821
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62837	Human	PMID:22266821
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:23799367
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:23799367
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P31946	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q04917	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q9Y5K6	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P08581	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O00459	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46108	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46109	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q92569	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:27059931
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q04917	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q13191	Human	PMID:29237719
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q8IY31	Human	PMID:29237719
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:A0A0H3L6J6	Human	PMID:30118682
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46108	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q96B97	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:O15357	Human	PMID:5668240
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P00533	Human	PMID:7657591
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46108	Human	PMID:8524328
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46108	Human	PMID:8626543
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P46109	Human	PMID:8626543
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27348	Human	PMID:8663231
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27348	Human	PMID:9092538
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27986	Human	PMID:9160881
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:Q62417	Human	PMID:9447983
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P27986	Human	PMID:9890970
Molecular Function	GO:0005515	protein binding	CBL	IPI	UniProtKB:P39688	Human	PMID:9890970
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:Q62417	Mouse	MGI:MGI:1201213|PMID:9447983
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:Q01279	Mouse	MGI:MGI:5553215|PMID:23799367
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:Q8R550	Mouse	MGI:MGI:5700492|PMID:21830225
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:Q9JLQ0	Mouse	MGI:MGI:5758812|PMID:12559036
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:P13379|UniProtKB:P39688|UniProtKB:Q9JLQ0	Mouse	MGI:MGI:5825410|PMID:27474268
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:P39688	Mouse	MGI:MGI:5508303|PMID:9890970
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:Q6Q899	Mouse	MGI:MGI:5468580|PMID:23374343
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:P16056	Mouse	MGI:MGI:5553025|PMID:24440350
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:Q64010	Mouse	MGI:MGI:1201213|PMID:9447983
Molecular Function	GO:0005515	protein binding	Cbl	IPI	UniProtKB:P00533	Mouse	MGI:MGI:4418647|PMID:7657591
Molecular Function	GO:0005515	protein binding	Cbl	IPI	PR:P39688	Mouse	PMID:8551236
Molecular Function	GO:0005515	protein binding	Cbl	IPI	PR:P43404	Mouse	PMID:8551236
Molecular Function	GO:0005515	protein binding	Cbl	IPI	PR:O08917	Mouse	PMID:16455755
Molecular Function	GO:0005515	protein binding	Cbl	IPI	PR:Q8R550	Mouse	PMID:11152963
Molecular Function	GO:0005515	protein binding	Cbl	IPI	RGD:620904	Rat	PMID:11152963|RGD:729812
Molecular Function	GO:0005515	protein binding	Cbl	IPI	RGD:1586598	Rat	PMID:14525909|RGD:11038810
Molecular Function	GO:0005515	protein binding	Cbl	IPI	RGD:1310357	Rat	PMID:17675467|RGD:11576315
Molecular Function	GO:0005515	protein binding	Cbl	IPI	RGD:620904	Rat	PMID:17675467|RGD:11576315
Molecular Function	GO:0005515	protein binding	Cbl	IPI	RGD:619758	Rat	PMID:9259313|RGD:11038829
Molecular Function	GO:0005515	protein binding	Cbl	IPI	RGD:2405	Rat	PMID:9348226|RGD:11038915
Molecular Function	GO:0019901	protein kinase binding	Cbl	IPI	RGD:3329	Rat	PMID:18773943|RGD:4108486
Molecular Function	GO:1990782	protein tyrosine kinase binding	Cbl	IPI	RGD:2641	Rat	PMID:12231245|RGD:632732
Molecular Function	GO:1990782	protein tyrosine kinase binding	Cbl	IPI	RGD:628758	Rat	PMID:16945503|RGD:1642613
Molecular Function	GO:1990782	protein tyrosine kinase binding	Cbl	IPI	RGD:3796	Rat	PMID:8920860|RGD:11576303
Molecular Function	GO:0017124	SH3 domain binding	CBL	IPI	UniProtKB:Q62417	Human	PMID:9447983
Molecular Function	GO:0017124	SH3 domain binding	Cbl	IPI	UniProtKB:Q62417|UniProtKB:Q64010	Mouse	MGI:MGI:1201213|PMID:9447983
Molecular Function	GO:0017124	SH3 domain binding	Cbl	IPI	RGD:732890	Rat	PMID:17675467|RGD:11576315
Molecular Function	GO:0017124	SH3 domain binding	Cbl	IDA		Rat	PMID:9259313|RGD:11038829
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Cbl	IDA		Rat	PMID:17675467|RGD:11576315
Cellular Component	GO:0030424	axon	Cbl	IDA		Rat	PMID:15128873|RGD:1642627
Cellular Component	GO:0005929	cilium	CBL	IDA		Human	PMID:29237719
Cellular Component	GO:0005929	cilium	Cbl	IDA		Mouse	MGI:MGI:6108066|PMID:29237719
Cellular Component	GO:0005829	cytosol	CBL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016600	flotillin complex	Cbl	IDA		Mouse	MGI:MGI:3690172|PMID:11001060
Cellular Component	GO:0005925	focal adhesion	Cbl	IDA		Rat	PMID:22203672|RGD:11576305
Cellular Component	GO:0005794	Golgi apparatus	CBL	IDA		Human	PMID:29237719
Cellular Component	GO:0005794	Golgi apparatus	Cbl	IDA		Mouse	MGI:MGI:6108066|PMID:29237719
Cellular Component	GO:0030426	growth cone	Cbl	IDA		Rat	PMID:15128873|RGD:1642627
Cellular Component	GO:0045121	membrane raft	Cbl	IDA		Rat	PMID:15128873|RGD:1642627
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cbl	IDA		Rat	PMID:15128873|RGD:1642627
Cellular Component	GO:0005886	plasma membrane	CBL	IDA		Human	PMID:15465819
Cellular Component	GO:0005886	plasma membrane	Cbl	IDA		Rat	PMID:18702941|RGD:11038822
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Cbl	IEP		Rat	PMID:19546888|RGD:11038823
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Cbl	IEP		Rat	PMID:24229686|RGD:11038824
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Cbl	IEP		Rat	PMID:15128873|RGD:1642627
Biological Process	GO:0060216	definitive hemopoiesis	cbl	IMP	ZFIN:ZDB-GENO-180726-1	Zfish	PMID:26104663
Biological Process	GO:0006974	DNA damage response	Cbl	IEP		Rat	PMID:19546888|RGD:11038823
Biological Process	GO:0008584	male gonad development	Cbl	IEP		Rat	PMID:16301331|RGD:1579837
Biological Process	GO:0043303	mast cell degranulation	Cbl	IEP		Rat	PMID:18243321|RGD:11576314
Biological Process	GO:0043066	negative regulation of apoptotic process	CBL	IMP		Human	PMID:18070883
Biological Process	GO:0043066	negative regulation of apoptotic process	Cbl	IMP		Rat	PMID:19546888|RGD:11038823
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	CBL	IMP		Human	PMID:25178484
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	CBL	IMP		Human	PMID:17003487
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	CBL	IMP		Human	PMID:25178484
Biological Process	GO:0051865	protein autoubiquitination	Cbl	IDA		Rat	PMID:22203672|RGD:11576305
Biological Process	GO:0006513	protein monoubiquitination	Cbl	IMP		Rat	PMID:22706924|RGD:11533125
Biological Process	GO:0000209	protein polyubiquitination	Cbl	IDA		Rat	PMID:17675467|RGD:11576315
Biological Process	GO:0016567	protein ubiquitination	CBL	IMP		Human	PMID:17094949
Biological Process	GO:0016567	protein ubiquitination	CBL	IDA		Human	PMID:17974561
Biological Process	GO:2000583	regulation of platelet-derived growth factor receptor-alpha signaling pathway	Cbl	IMP		Mouse	MGI:MGI:6108066|PMID:29237719
Biological Process	GO:0032487	regulation of Rap protein signal transduction	Cbl	IMP	MGI:MGI:2180576	Mouse	PMID:12671687
Biological Process	GO:0014823	response to activity	Cbl	IEP		Rat	PMID:18502271|RGD:11038815
Biological Process	GO:0046677	response to antibiotic	Cbl	IDA		Rat	PMID:18773943|RGD:4108486
Biological Process	GO:0045471	response to ethanol	Cbl	IEP		Rat	PMID:16105861|RGD:1579848
Biological Process	GO:0010332	response to gamma radiation	Cbl	IEP		Rat	PMID:16301331|RGD:1579837
Biological Process	GO:0042594	response to starvation	Cbl	IEP		Rat	PMID:14525909|RGD:11038810
Biological Process	GO:0033574	response to testosterone	Cbl	IEP		Rat	PMID:16301331|RGD:1579837
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	CBL	IMP		Human	PMID:25178484

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern