Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CBS
  • Mouse genes Cbs
  • Rat genes Cbs
  • Zfish genes cbsa,cbsb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cbs

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070025	carbon monoxide binding	CBS	IDA		Human	PMID:24515102
Molecular Function	GO:0004122	cystathionine beta-synthase activity	CBS	IDA		Human	PMID:18776696
Molecular Function	GO:0004122	cystathionine beta-synthase activity	CBS	IDA		Human	PMID:19010420
Molecular Function	GO:0004122	cystathionine beta-synthase activity	CBS	IDA		Human	PMID:22985361
Molecular Function	GO:0004122	cystathionine beta-synthase activity	CBS	IDA		Human	PMID:23981774
Molecular Function	GO:0004122	cystathionine beta-synthase activity	CBS	IDA		Human	PMID:24416422
Molecular Function	GO:0004122	cystathionine beta-synthase activity	CBS	IDA		Human	PMID:7929220
Molecular Function	GO:0004122	cystathionine beta-synthase activity	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:7878023
Molecular Function	GO:0004122	cystathionine beta-synthase activity	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:10953023
Molecular Function	GO:0004122	cystathionine beta-synthase activity	Cbs	IDA		Rat	PMID:9359866|RGD:1359024
Molecular Function	GO:0019899	enzyme binding	CBS	IPI	UniProtKB:O00257	Human	PMID:17087506
Molecular Function	GO:0019899	enzyme binding	CBS	IPI	UniProtKB:O75925	Human	PMID:17087506
Molecular Function	GO:0019899	enzyme binding	CBS	IPI	UniProtKB:Q9Y6X2	Human	PMID:17087506
Molecular Function	GO:0020037	heme binding	CBS	IMP		Human	PMID:18776696
Molecular Function	GO:0020037	heme binding	CBS	IDA		Human	PMID:24515102
Molecular Function	GO:0020037	heme binding	CBS	IDA		Human	PMID:7929220
Molecular Function	GO:0042802	identical protein binding	CBS	IPI	UniProtKB:P35520	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	CBS	IPI	UniProtKB:P35520	Human	PMID:19447967
Molecular Function	GO:0042802	identical protein binding	CBS	IPI	UniProtKB:P35520	Human	PMID:21900206
Molecular Function	GO:0042802	identical protein binding	CBS	IPI	UniProtKB:P35520	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	CBS	IPI	UniProtKB:P35520	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	CBS	IPI	UniProtKB:P35520	Human	PMID:31515488
Molecular Function	GO:0043167	ion binding	CBS	EXP		Human	PMID:29410458
Molecular Function	GO:0072341	modified amino acid binding	CBS	IDA		Human	PMID:20031578
Molecular Function	GO:0070026	nitric oxide binding	CBS	IDA		Human	PMID:24416422
Molecular Function	GO:0070026	nitric oxide binding	CBS	IDA		Human	PMID:24515102
Molecular Function	GO:0050421	nitrite reductase (NO-forming) activity	CBS	IDA		Human	PMID:24416422
Molecular Function	GO:0019825	oxygen binding	CBS	IDA		Human	PMID:24515102
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P51116	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q96S59	Human	PMID:17087506
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P51116	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P25786	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P54619	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P57075	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q08426	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q13526	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q7KZS0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P25786	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P51116	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P57075	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q08426	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q13526	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:O75928-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q9UJ78-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:O75344	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P06241	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P22466	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P35222	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q15438	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q92993-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CBS	IPI	UniProtKB:Q9UQM7	Human	PMID:32814053
Molecular Function	GO:0042803	protein homodimerization activity	CBS	IDA		Human	PMID:11483494
Molecular Function	GO:0030170	pyridoxal phosphate binding	CBS	IDA		Human	PMID:18776696
Molecular Function	GO:0030170	pyridoxal phosphate binding	CBS	IDA		Human	PMID:7929220
Molecular Function	GO:1904047	S-adenosyl-L-methionine binding	CBS	IDA		Human	PMID:22985361
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CBS	IPI	UniProtKB:P63279	Human	PMID:17087506
Cellular Component	GO:0005737	cytoplasm	CBS	IDA		Human	PMID:23981774
Cellular Component	GO:0005829	cytosol	CBS	HDA		Human	PMID:16780588
Cellular Component	GO:0005634	nucleus	CBS	IDA		Human	PMID:17087506
Biological Process	GO:0003401	axis elongation	cbsb	IMP	ZFIN:ZDB-GENO-180808-2	Zfish	PMID:29503817
Biological Process	GO:0003401	axis elongation	cbsb	IMP	ZFIN:ZDB-MRPHLNO-180727-2	Zfish	PMID:29503817
Biological Process	GO:0097746	blood vessel diameter maintenance	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:10953023
Biological Process	GO:0001974	blood vessel remodeling	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:12433838
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15622513
Biological Process	GO:0071456	cellular response to hypoxia	Cbs	IDA		Rat	PMID:20149843|RGD:8554341
Biological Process	GO:0021587	cerebellum morphogenesis	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:16160063
Biological Process	GO:0019344	cysteine biosynthetic process	CBS	IDA		Human	PMID:24416422
Biological Process	GO:0019344	cysteine biosynthetic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15030387
Biological Process	GO:0042262	DNA protection	CBS	IMP		Human	PMID:24534463
Biological Process	GO:0001958	endochondral ossification	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15622513
Biological Process	GO:0043418	homocysteine catabolic process	CBS	IDA		Human	PMID:18776696
Biological Process	GO:0043418	homocysteine catabolic process	CBS	IDA		Human	PMID:24416422
Biological Process	GO:0050667	homocysteine metabolic process	CBS	IDA		Human	PMID:19010420
Biological Process	GO:0050667	homocysteine metabolic process	CBS	IDA		Human	PMID:20031578
Biological Process	GO:0050667	homocysteine metabolic process	CBS	IDA		Human	PMID:23981774
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15916860
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15622513
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:10993757
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15131763
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:10953023
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:7878023
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15555590
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:16226235
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:18541157
Biological Process	GO:0050667	homocysteine metabolic process	Cbs	IDA		Rat	PMID:9359866|RGD:1359024
Biological Process	GO:0070814	hydrogen sulfide biosynthetic process	CBS	IDA		Human	PMID:15520012
Biological Process	GO:0070814	hydrogen sulfide biosynthetic process	CBS	IDA		Human	PMID:24416422
Biological Process	GO:0070814	hydrogen sulfide biosynthetic process	Cbs	IDA		Rat	PMID:20149843|RGD:8554341
Biological Process	GO:0019448	L-cysteine catabolic process	CBS	IDA		Human	PMID:15520012
Biological Process	GO:0006565	L-serine catabolic process	CBS	IDA		Human	PMID:18776696
Biological Process	GO:0006563	L-serine metabolic process	CBS	IDA		Human	PMID:19010420
Biological Process	GO:0060135	maternal process involved in female pregnancy	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:16984962
Biological Process	GO:0043066	negative regulation of apoptotic process	Cbs	IDA		Rat	PMID:20149843|RGD:8554341
Biological Process	GO:0050666	regulation of homocysteine metabolic process	cbsb	IMP	ZFIN:ZDB-GENO-180808-2	Zfish	PMID:29503817
Biological Process	GO:0050666	regulation of homocysteine metabolic process	cbsb	IMP	ZFIN:ZDB-MRPHLNO-180727-2	Zfish	PMID:29503817
Biological Process	GO:0043506	regulation of JUN kinase activity	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:15030387
Biological Process	GO:0010749	regulation of nitric oxide mediated signal transduction	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:10953023
Biological Process	GO:0051593	response to folic acid	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:10993757
Biological Process	GO:0031667	response to nutrient levels	Cbs	IEP		Rat	PMID:19352060|RGD:2306414
Biological Process	GO:0006801	superoxide metabolic process	Cbs	IMP	MGI:MGI:1857139	Mouse	PMID:10953023
Biological Process	GO:0019346	transsulfuration	Cbs	IDA		Rat	PMID:16636197|RGD:1600624

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern