Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCDC88A
  • Mouse genes Ccdc88a
  • Rat genes Ccdc88a
  • Zfish genes ccdc88aa,ccdc88ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccdc88a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	CCDC88A	IDA		Human	PMID:16139227
Molecular Function	GO:0005154	epidermal growth factor receptor binding	CCDC88A	IPI	UniProtKB:P00533	Human	PMID:20462955
Molecular Function	GO:0005154	epidermal growth factor receptor binding	CCDC88A	IPI	UniProtKB:P00533	Human	PMID:25187647
Molecular Function	GO:0001965	G-protein alpha-subunit binding	CCDC88A	IPI	UniProtKB:P08753	Human	PMID:19211784
Molecular Function	GO:0001965	G-protein alpha-subunit binding	CCDC88A	IPI	UniProtKB:P08753	Human	PMID:23509302
Molecular Function	GO:0001965	G-protein alpha-subunit binding	CCDC88A	IPI	UniProtKB:P08753	Human	PMID:27621449
Molecular Function	GO:0001965	G-protein alpha-subunit binding	CCDC88A	IPI	UniProtKB:P08754	Human	PMID:27621449
Molecular Function	GO:0001965	G-protein alpha-subunit binding	CCDC88A	IPI	UniProtKB:P63092	Human	PMID:27621449
Molecular Function	GO:0031682	G-protein gamma-subunit binding	Ccdc88a	IPI	RGD:2716	Rat	PMID:15749703|RGD:10401274
Molecular Function	GO:0005092	GDP-dissociation inhibitor activity	CCDC88A	IDA		Human	PMID:27621449
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	CCDC88A	IDA		Human	PMID:19211784
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	CCDC88A	IDA		Human	PMID:23509302
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	CCDC88A	IDA		Human	PMID:27864364
Molecular Function	GO:0005158	insulin receptor binding	CCDC88A	IPI	UniProtKB:P06213	Human	PMID:25187647
Molecular Function	GO:0008017	microtubule binding	Ccdc88a	IDA		Mouse	MGI:MGI:3710717|PMID:15882442
Molecular Function	GO:0035091	phosphatidylinositol binding	CCDC88A	IDA		Human	PMID:16139227
Molecular Function	GO:0005515	protein binding	Ccdc88a	IPI	UniProtKB:Q811T9	Mouse	MGI:MGI:4411937|PMID:19778506
Molecular Function	GO:0005515	protein binding	Ccdc88a	IPI	PR:Q8BRT1	Mouse	PMID:24211587
Molecular Function	GO:0042803	protein homodimerization activity	CCDC88A	IPI	UniProtKB:Q3V6T2	Human	PMID:16139227
Molecular Function	GO:0043422	protein kinase B binding	CCDC88A	IPI	UniProtKB:P31749	Human	PMID:16139227
Molecular Function	GO:0043422	protein kinase B binding	Ccdc88a	IPI	UniProtKB:P31750	Mouse	MGI:MGI:3581096|PMID:15753085
Molecular Function	GO:0005080	protein kinase C binding	CCDC88A	IPI	UniProtKB:Q04759	Human	PMID:23509302
Molecular Function	GO:0042169	SH2 domain binding	CCDC88A	IPI	UniProtKB:P27986	Human	PMID:21954290
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	CCDC88A	IPI	UniProtKB:P35968	Human	PMID:25187647
Cellular Component	GO:0031252	cell leading edge	Ccdc88a	IDA		Mouse	PMID:24211587
Cellular Component	GO:0005814	centriole	CCDC88A	IDA		Human	PMID:27623382
Cellular Component	GO:0036064	ciliary basal body	CCDC88A	IDA		Human	PMID:27623382
Cellular Component	GO:0030142	COPI-coated Golgi to ER transport vesicle	Ccdc88a	IDA		Rat	PMID:15749703|RGD:10401274
Cellular Component	GO:0031410	cytoplasmic vesicle	CCDC88A	IDA		Human	PMID:15882442
Cellular Component	GO:0005829	cytosol	CCDC88A	IDA		Human	PMID:15749703
Cellular Component	GO:0005829	cytosol	CCDC88A	IDA		Human	PMID:27864364
Cellular Component	GO:0005783	endoplasmic reticulum	CCDC88A	IDA		Human	PMID:15882442
Cellular Component	GO:0005794	Golgi apparatus	CCDC88A	IDA		Human	PMID:15882442
Cellular Component	GO:0030027	lamellipodium	CCDC88A	IDA		Human	PMID:16139227
Cellular Component	GO:0016020	membrane	CCDC88A	IDA		Human	PMID:15749703
Cellular Component	GO:0016020	membrane	CCDC88A	IDA		Human	PMID:15882442
Cellular Component	GO:0005886	plasma membrane	CCDC88A	IDA		Human	PMID:15882442
Cellular Component	GO:0005886	plasma membrane	CCDC88A	IDA		Human	PMID:27864364
Biological Process	GO:0032147	activation of protein kinase activity	CCDC88A	IDA		Human	PMID:21954290
Biological Process	GO:0032148	activation of protein kinase B activity	Ccdc88a	IDA		Mouse	MGI:MGI:3581096|PMID:15753085
Biological Process	GO:0016477	cell migration	CCDC88A	IMP		Human	PMID:16139227
Biological Process	GO:0030032	lamellipodium assembly	CCDC88A	IMP		Human	PMID:16139227
Biological Process	GO:0072660	maintenance of protein location in plasma membrane	CCDC88A	IDA		Human	PMID:20462955
Biological Process	GO:0061024	membrane organization	CCDC88A	IDA		Human	PMID:15882442
Biological Process	GO:0045724	positive regulation of cilium assembly	CCDC88A	IMP		Human	PMID:27623382
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	CCDC88A	IDA		Human	PMID:20462955
Biological Process	GO:1903566	positive regulation of protein localization to cilium	CCDC88A	IMP		Human	PMID:27623382
Biological Process	GO:0051496	positive regulation of stress fiber assembly	CCDC88A	IMP		Human	PMID:16139227
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	CCDC88A	IMP		Human	PMID:16139227
Biological Process	GO:0042127	regulation of cell population proliferation	Ccdc88a	IMP		Mouse	MGI:MGI:3581096|PMID:15753085
Biological Process	GO:0006275	regulation of DNA replication	Ccdc88a	IMP		Mouse	MGI:MGI:3581096|PMID:15753085
Biological Process	GO:0010975	regulation of neuron projection development	Ccdc88a	IDA		Mouse	MGI:MGI:4411937|PMID:19778506
Biological Process	GO:0001932	regulation of protein phosphorylation	Ccdc88a	IDA		Mouse	MGI:MGI:3581096|PMID:15753085
Biological Process	GO:0007264	small GTPase mediated signal transduction	CCDC88A	IDA		Human	PMID:19211784
Biological Process	GO:0007264	small GTPase mediated signal transduction	CCDC88A	IDA		Human	PMID:23509302
Biological Process	GO:0007264	small GTPase mediated signal transduction	CCDC88A	IDA		Human	PMID:27621449
Biological Process	GO:0007264	small GTPase mediated signal transduction	CCDC88A	IDA		Human	PMID:27864364
Biological Process	GO:0031929	TOR signaling	Ccdc88a	IDA		Mouse	MGI:MGI:4411937|PMID:19778506

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern