Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCKBR
  • Mouse genes Cckbr
  • Rat genes Cckbr
  • Zfish genes cckbra
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cckbr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004951	cholecystokinin receptor activity	CCKBR	IDA		Human	PMID:7681836
Molecular Function	GO:0015054	gastrin receptor activity	CCKBR	IDA		Human	PMID:10913157
Molecular Function	GO:0015054	gastrin receptor activity	CCKBR	IDA		Human	PMID:7681836
Molecular Function	GO:0015054	gastrin receptor activity	Cckbr	IMP		Rat	PMID:1528881|RGD:634707
Molecular Function	GO:0017046	peptide hormone binding	CCKBR	IPI	CHEBI:80327	Human	PMID:7681836
Molecular Function	GO:0017046	peptide hormone binding	CCKBR	IPI	UniProtKB:P01350	Human	PMID:7681836
Molecular Function	GO:0005515	protein binding	CCKBR	IPI	UniProtKB:Q06124	Human	PMID:16963136
Molecular Function	GO:0005515	protein binding	CCKBR	IPI	UniProtKB:P06307:PRO_0000010542	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	CCKBR	IPI	UniProtKB:Q9P121	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Cckbr	IPI	PR:P09240	Mouse	PMID:8876222
Molecular Function	GO:0005515	protein binding	Cckbr	IPI	PR:P48757	Mouse	PMID:8876222
Molecular Function	GO:0031741	type B gastrin/cholecystokinin receptor binding	CCKBR	IDA		Human	PMID:1280419
Molecular Function	GO:0031741	type B gastrin/cholecystokinin receptor binding	CCKBR	IDA		Human	PMID:8185642
Cellular Component	GO:0005737	cytoplasm	Cckbr	IDA		Rat	PMID:17088981|RGD:2311330
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CCKBR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Cckbr	IDA		Mouse	PMID:8876222
Cellular Component	GO:0005634	nucleus	Cckbr	IDA		Rat	PMID:17088981|RGD:2311330
Cellular Component	GO:0005886	plasma membrane	CCKBR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Cckbr	IDA		Rat	PMID:17088981|RGD:2311330
Biological Process	GO:0006915	apoptotic process	Cckbr	IMP		Rat	PMID:17088981|RGD:2311330
Biological Process	GO:0002209	behavioral defense response	Cckbr	IMP		Rat	PMID:17498673|RGD:2311328
Biological Process	GO:0038188	cholecystokinin signaling pathway	CCKBR	IDA		Human	PMID:7681836
Biological Process	GO:0007586	digestion	Cckbr	IEP		Rat	PMID:15161757|RGD:1358452
Biological Process	GO:0048565	digestive tract development	Cckbr	IMP	MGI:MGI:2384535	Mouse	PMID:15476751
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Cckbr	IMP		Rat	PMID:17226751|RGD:2311329
Biological Process	GO:0044849	estrous cycle	Cckbr	IDA		Rat	PMID:17045752|RGD:2311331
Biological Process	GO:0001696	gastric acid secretion	Cckbr	IGI	MGI:MGI:108482	Mouse	PMID:15476751
Biological Process	GO:0001696	gastric acid secretion	Cckbr	IMP	MGI:MGI:2384535	Mouse	PMID:15476751
Biological Process	GO:0048732	gland development	Cckbr	IMP	MGI:MGI:2384535	Mouse	PMID:15476751
Biological Process	GO:0001821	histamine secretion	Cckbr	IMP		Rat	PMID:17531331|RGD:2311327
Biological Process	GO:0045851	pH reduction	Cckbr	IMP	MGI:MGI:2180591	Mouse	PMID:19448635
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	CCKBR	IDA		Human	PMID:7681836
Biological Process	GO:2000987	positive regulation of behavioral fear response	Cckbr	IMP		Rat	PMID:12373548|RGD:1358453
Biological Process	GO:0008284	positive regulation of cell population proliferation	CCKBR	IDA		Human	PMID:10913157
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cckbr	IMP		Rat	PMID:17531331|RGD:2311327
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	CCKBR	IDA		Human	PMID:10913157
Biological Process	GO:0090274	positive regulation of somatostatin secretion	Cckbr	IMP		Rat	PMID:19959964|RGD:4110825
Biological Process	GO:0050806	positive regulation of synaptic transmission	Cckbr	IMP		Rat	PMID:19386755|RGD:2311324
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Cckbr	IMP		Rat	PMID:17904218|RGD:2311326
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Cckbr	IMP		Rat	PMID:18088282|RGD:2311325
Biological Process	GO:0051930	regulation of sensory perception of pain	Cckbr	IMP		Rat	PMID:15647484|RGD:1626108
Biological Process	GO:0051930	regulation of sensory perception of pain	Cckbr	IMP		Rat	PMID:19103210|RGD:2303798
Biological Process	GO:0032868	response to insulin	Cckbr	IEP		Rat	PMID:15161757|RGD:1358452

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern