Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCL2
  • Mouse genes Ccl12
  • Rat genes Ccl12
  • Zfish genes ccl38a.4,ccl38a.5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccl12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031727	CCR2 chemokine receptor binding	Ccl12	IPI	UniProtKB:P51683	Mouse	MGI:MGI:84964|PMID:8996246
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:Q2F862	Human	PMID:26095031
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P80075	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:P78317	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL2	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Cellular Component	GO:0005576	extracellular region	CCL2	IDA		Human	PMID:20041150
Biological Process	GO:0001525	angiogenesis	Ccl12	IDA		Mouse	MGI:MGI:4943388|PMID:18334747
Biological Process	GO:0043615	astrocyte cell migration	CCL2	IDA		Human	PMID:12271471
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0071347	cellular response to interleukin-1	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0071407	cellular response to organic cyclic compound	CCL2	IDA		Human	PMID:21147091
Biological Process	GO:0071356	cellular response to tumor necrosis factor	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0071346	cellular response to type II interferon	CCL2	IEP		Human	PMID:9407497
Biological Process	GO:0019221	cytokine-mediated signaling pathway	CCL2	IDA		Human	PMID:12207323
Biological Process	GO:0007010	cytoskeleton organization	CCL2	IDA		Human	PMID:10072545
Biological Process	GO:0006954	inflammatory response	CCL2	IDA		Human	PMID:21147091
Biological Process	GO:0006954	inflammatory response	Ccl12	IDA		Mouse	MGI:MGI:84964|PMID:8996246
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	CCL2	IDA		Human	PMID:21147091
Biological Process	GO:0048246	macrophage chemotaxis	CCL2	IDA		Human	PMID:12207323
Biological Process	GO:0000165	MAPK cascade	CCL2	IMP		Human	PMID:21147091
Biological Process	GO:0002548	monocyte chemotaxis	CCL2	IDA		Human	PMID:12207323
Biological Process	GO:0002548	monocyte chemotaxis	Ccl12	IDA		Mouse	MGI:MGI:84964|PMID:8996246
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	CCL2	IMP		Human	PMID:25466836
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	CCL2	IDA		Human	PMID:12753088
Biological Process	GO:0070664	negative regulation of leukocyte proliferation	Ccl12	IMP		Rat	PMID:24030423|RGD:9685052
Biological Process	GO:2000502	negative regulation of natural killer cell chemotaxis	CCL2	IDA		Human	PMID:7545673
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	CCL2	IDA		Human	PMID:12753088
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	CCL2	IMP		Human	PMID:25466836
Biological Process	GO:0090280	positive regulation of calcium ion import	CCL2	IDA		Human	PMID:10925302
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	CCL2	IMP		Human	PMID:25466836
Biological Process	GO:0002687	positive regulation of leukocyte migration	Ccl12	IMP		Rat	PMID:24030423|RGD:9685052
Biological Process	GO:0043491	protein kinase B signaling	CCL2	IMP		Human	PMID:21147091
Biological Process	GO:0008360	regulation of cell shape	CCL2	IDA		Human	PMID:10072545

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern