Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCL21
  • Mouse genes Ccl21a
  • Rat genes Ccl21
  • Zfish genes ccl25a,ccl25b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccl21a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031732	CCR7 chemokine receptor binding	Ccl21a	IPI	UniProtKB:P32248	Mouse	MGI:MGI:5788401|PMID:9507024
Molecular Function	GO:0008009	chemokine activity	CCL21	IDA		Human	PMID:15778365
Molecular Function	GO:0008009	chemokine activity	CCL21	IDA		Human	PMID:18308860
Molecular Function	GO:0008009	chemokine activity	Ccl21a	IMP		Mouse	MGI:MGI:6141968|PMID:27400149
Molecular Function	GO:0008009	chemokine activity	Ccl21a	IDA		Mouse	MGI:MGI:5284817|PMID:12200351
Molecular Function	GO:0008009	chemokine activity	ccl25b	IDA		Zfish	PMID:18482437
Molecular Function	GO:0042379	chemokine receptor binding	CCL21	IDA		Human	PMID:23341447
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q86YL7	Human	PMID:14978162
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:O95715	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:P02778	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:P10720	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:P48061	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q07325	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q92583	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q99616	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q9NRJ3	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q9Y258	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q5BVD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q5XKR4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q6UX40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL21	IPI	UniProtKB:Q8WXH2	Human	PMID:32814053
Biological Process	GO:0090630	activation of GTPase activity	CCL21	IDA		Human	PMID:15778365
Biological Process	GO:0060326	cell chemotaxis	CCL21	IDA		Human	PMID:18308860
Biological Process	GO:0048469	cell maturation	Ccl21a	IDA		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:1990869	cellular response to chemokine	Ccl21a	IMP		Mouse	MGI:MGI:6141968|PMID:27400149
Biological Process	GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway	Ccl21a	IMP		Mouse	MGI:MGI:6141968|PMID:27400149
Biological Process	GO:0002407	dendritic cell chemotaxis	CCL21	IDA		Human	PMID:15778365
Biological Process	GO:0002407	dendritic cell chemotaxis	Ccl21a	IDA		Mouse	MGI:MGI:5284817|PMID:12200351
Biological Process	GO:0097026	dendritic cell dendrite assembly	Ccl21a	IDA		Mouse	MGI:MGI:5284817|PMID:12200351
Biological Process	GO:0001768	establishment of T cell polarity	CCL21	IDA		Human	PMID:12729902
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	CCL21	IDA		Human	PMID:18308860
Biological Process	GO:0001771	immunological synapse formation	Ccl21a	IDA		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0050930	induction of positive chemotaxis	Ccl21a	IDA		Mouse	PMID:9548511
Biological Process	GO:0048535	lymph node development	Ccl21a	IMP	MGI:MGI:1857881	Mouse	PMID:12732660
Biological Process	GO:0097535	lymphoid lineage cell migration into thymus	ccl25a	IGI	ZFIN:ZDB-MRPHLNO-071113-1,ZFIN:ZDB-MRPHLNO-121001-4	Zfish	PMID:22342843
Biological Process	GO:0097535	lymphoid lineage cell migration into thymus	ccl25a	IMP	ZFIN:ZDB-MRPHLNO-121001-4	Zfish	PMID:22342843
Biological Process	GO:0097535	lymphoid lineage cell migration into thymus	ccl25b	IGI	ZFIN:ZDB-MRPHLNO-071113-1,ZFIN:ZDB-MRPHLNO-121001-6	Zfish	PMID:22342843
Biological Process	GO:0035759	mesangial cell-matrix adhesion	CCL21	IDA		Human	PMID:15569314
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	CCL21	IDA		Human	PMID:15059845
Biological Process	GO:2000548	negative regulation of dendritic cell dendrite assembly	Ccl21a	IDA		Mouse	MGI:MGI:5284817|PMID:12200351
Biological Process	GO:1903237	negative regulation of leukocyte tethering or rolling	CCL21	IDA		Human	PMID:18308860
Biological Process	GO:0030838	positive regulation of actin filament polymerization	CCL21	IDA		Human	PMID:11242036
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	CCL21	IDA		Human	PMID:15569314
Biological Process	GO:2000147	positive regulation of cell motility	CCL21	IDA		Human	PMID:15778365
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	CCL21	IDA		Human	PMID:15569314
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	CCL21	IDA		Human	PMID:18308860
Biological Process	GO:0050921	positive regulation of chemotaxis	Ccl21a	IDA		Mouse	MGI:MGI:5788401|PMID:9507024
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	Ccl21a	IDA		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CCL21	IDA		Human	PMID:12729902
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CCL21	IDA		Human	PMID:15778365
Biological Process	GO:0051491	positive regulation of filopodium assembly	CCL21	IDA		Human	PMID:15569314
Biological Process	GO:0010560	positive regulation of glycoprotein biosynthetic process	Ccl21a	IDA		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CCL21	IDA		Human	PMID:15059845
Biological Process	GO:0046330	positive regulation of JNK cascade	CCL21	IDA		Human	PMID:15778365
Biological Process	GO:2000529	positive regulation of myeloid dendritic cell chemotaxis	CCL21	IDA		Human	PMID:14592837
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	CCL21	IDA		Human	PMID:21051556
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	CCL21	IDA		Human	PMID:15059845
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	CCL21	IDA		Human	PMID:15778365
Biological Process	GO:0045860	positive regulation of protein kinase activity	CCL21	IDA		Human	PMID:15059845
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	CCL21	IDA		Human	PMID:15059845
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	CCL21	IDA		Human	PMID:15778365
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	CCL21	IDA		Human	PMID:11242036
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	Ccl21a	IDA		Mouse	MGI:MGI:2667257|PMID:12609829
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	Ccl21a	IMP		Mouse	MGI:MGI:6141968|PMID:27400149
Biological Process	GO:2000406	positive regulation of T cell migration	CCL21	IDA		Human	PMID:23620790
Biological Process	GO:2000471	regulation of hematopoietic stem cell migration	ccl25b	IMP	ZFIN:ZDB-MRPHLNO-171018-1	Zfish	PMID:28803829
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	ccl25b	IMP	ZFIN:ZDB-MRPHLNO-171018-1	Zfish	PMID:28803829
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	CCL21	IDA		Human	PMID:14592837
Biological Process	GO:0034695	response to prostaglandin E	CCL21	IDA		Human	PMID:14592837
Biological Process	GO:0031529	ruffle organization	CCL21	IDA		Human	PMID:15569314
Biological Process	GO:0031295	T cell costimulation	Ccl21a	IDA		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0072679	thymocyte migration	ccl25a	IMP	ZFIN:ZDB-MRPHLNO-121010-3	Zfish	PMID:22842207
Biological Process	GO:0072679	thymocyte migration	ccl25a	IMP	ZFIN:ZDB-MRPHLNO-121010-4	Zfish	PMID:22842207
Biological Process	GO:0048538	thymus development	ccl25a	IMP		Zfish	PMID:19559469

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern