Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCL18,CCL3,CCL3L1,CCL3L3
  • Mouse genes Ccl3
  • Rat genes Ccl3
  • Zfish genes ccl35.1,ccl35.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	CCL3	IDA		Human	PMID:15764707
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL3	IPI	UniProtKB:P32246	Human	PMID:10660125
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL3	IPI	UniProtKB:P32246	Human	PMID:15764707
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL3	IPI	UniProtKB:P32246	Human	PMID:7545673
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL3	IPI	UniProtKB:P32246	Human	PMID:8699119
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	CCL3	IPI	UniProtKB:P51681	Human	PMID:10679098
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	CCL3	IPI	UniProtKB:P51681	Human	PMID:8699119
Molecular Function	GO:0042056	chemoattractant activity	CCL3	IDA		Human	PMID:10072545
Molecular Function	GO:0042056	chemoattractant activity	CCL3	IDA		Human	PMID:10660125
Molecular Function	GO:0042056	chemoattractant activity	CCL3	IDA		Human	PMID:10706735
Molecular Function	GO:0042056	chemoattractant activity	CCL3	IDA		Human	PMID:15001559
Molecular Function	GO:0008009	chemokine activity	CCL3	IDA		Human	PMID:10072545
Molecular Function	GO:0008009	chemokine activity	CCL3	IDA		Human	PMID:10660125
Molecular Function	GO:0008009	chemokine activity	Ccl3	IDA		Mouse	PMID:7594543
Molecular Function	GO:0008009	chemokine activity	Ccl3	IDA		Rat	PMID:10466578|RGD:2303107
Molecular Function	GO:0042802	identical protein binding	CCL3	IPI	UniProtKB:P10147	Human	PMID:20959807
Molecular Function	GO:0016301	kinase activity	CCL3	IDA		Human	PMID:21403648
Molecular Function	GO:0016004	phospholipase activator activity	CCL3	IDA		Human	PMID:10734056
Molecular Function	GO:0005515	protein binding	CCL3	IPI	UniProtKB:P14735	Human	PMID:20959807
Molecular Function	GO:0005515	protein binding	CCL3	IPI	UniProtKB:P26651	Human	PMID:21784977
Molecular Function	GO:0005515	protein binding	CCL3	IPI	UniProtKB:Q2F862	Human	PMID:26095031
Molecular Function	GO:0005515	protein binding	CCL3	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL3	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL3L1	IPI	UniProtKB:Q7Z7N9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL3L1	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL3L1	IPI	UniProtKB:Q96GZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL3L1	IPI	UniProtKB:Q99735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCL18	IPI	UniProtKB:Q9BZ71	Human	PMID:21481794
Molecular Function	GO:0005515	protein binding	Ccl3	IPI	UniProtKB:E9M5R0	Mouse	MGI:MGI:5926971|PMID:26671708
Molecular Function	GO:0005515	protein binding	Ccl3	IPI	PR:P51678	Mouse	PMID:7594543
Molecular Function	GO:0005515	protein binding	Ccl3	IPI	PR:O08707	Mouse	PMID:9139699
Molecular Function	GO:0005515	protein binding	Ccl3	IPI	PR:P51675	Mouse	PMID:7594543
Molecular Function	GO:0004672	protein kinase activity	CCL3	IDA		Human	PMID:10734056
Cellular Component	GO:0005737	cytoplasm	CCL3	IDA		Human	PMID:21784977
Cellular Component	GO:0005829	cytosol	CCL3	IDA		Human	PMID:19523456
Cellular Component	GO:0005576	extracellular region	CCL3	IDA		Human	PMID:20041150
Cellular Component	GO:0005615	extracellular space	CCL3	IDA		Human	PMID:20167378
Cellular Component	GO:0005615	extracellular space	CCL3	IDA		Human	PMID:21403648
Cellular Component	GO:0005615	extracellular space	Ccl3	IDA		Mouse	PMID:23460747
Cellular Component	GO:0005615	extracellular space	Ccl3	IDA		Mouse	PMID:22960654
Cellular Component	GO:0005615	extracellular space	Ccl3	IDA		Mouse	PMID:19139201
Biological Process	GO:0043615	astrocyte cell migration	Ccl3	IDA		Mouse	MGI:MGI:3044466|PMID:15155903
Biological Process	GO:0006816	calcium ion transport	CCL3	IDA		Human	PMID:10734056
Biological Process	GO:0019722	calcium-mediated signaling	CCL3	IDA		Human	PMID:10072545
Biological Process	GO:0019722	calcium-mediated signaling	CCL3	IDA		Human	PMID:19523456
Biological Process	GO:0001775	cell activation	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0007267	cell-cell signaling	CCL3	IDA		Human	PMID:10679098
Biological Process	GO:0071347	cellular response to interleukin-1	CCL3	IEP		Human	PMID:9407497
Biological Process	GO:0071407	cellular response to organic cyclic compound	CCL3	IDA		Human	PMID:21147091
Biological Process	GO:0071356	cellular response to tumor necrosis factor	CCL3	IEP		Human	PMID:9407497
Biological Process	GO:0071346	cellular response to type II interferon	CCL3	IEP		Human	PMID:9407497
Biological Process	GO:0006935	chemotaxis	CCL3	IDA		Human	PMID:10679098
Biological Process	GO:0007010	cytoskeleton organization	CCL3	IDA		Human	PMID:10072545
Biological Process	GO:0048245	eosinophil chemotaxis	CCL3	IDA		Human	PMID:10072545
Biological Process	GO:0043308	eosinophil degranulation	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0006887	exocytosis	CCL3	IDA		Human	PMID:10734056
Biological Process	GO:0071621	granulocyte chemotaxis	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0006954	inflammatory response	CCL3	IDA		Human	PMID:10679098
Biological Process	GO:0006954	inflammatory response	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0006954	inflammatory response	CCL3	IDA		Human	PMID:21147091
Biological Process	GO:0006954	inflammatory response	Ccl3	IEP		Rat	PMID:12144807|RGD:2303104
Biological Process	GO:0006874	intracellular calcium ion homeostasis	CCL3	IDA		Human	PMID:10072545
Biological Process	GO:0006874	intracellular calcium ion homeostasis	CCL3	IDA		Human	PMID:10734056
Biological Process	GO:0006874	intracellular calcium ion homeostasis	CCL3	IDA		Human	PMID:21403648
Biological Process	GO:0030595	leukocyte chemotaxis	Ccl3	IDA		Rat	PMID:7722328|RGD:727687
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	CCL3	IDA		Human	PMID:21147091
Biological Process	GO:0048247	lymphocyte chemotaxis	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0048246	macrophage chemotaxis	Ccl3	IGI	UniProtKB:P22893	Mouse	MGI:MGI:5301204|PMID:21784977
Biological Process	GO:0000165	MAPK cascade	CCL3	IEP		Human	PMID:12032188
Biological Process	GO:0000165	MAPK cascade	CCL3	IMP		Human	PMID:21147091
Biological Process	GO:0002548	monocyte chemotaxis	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0043922	negative regulation by host of viral transcription	CCL3	IDA		Human	PMID:10841574
Biological Process	GO:0030502	negative regulation of bone mineralization	CCL3	IDA		Human	PMID:21403648
Biological Process	GO:0010629	negative regulation of gene expression	CCL3	IDA		Human	PMID:21403648
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	CCL3	IDA		Human	PMID:21403648
Biological Process	GO:0030593	neutrophil chemotaxis	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0030593	neutrophil chemotaxis	Ccl3	IDA		Rat	PMID:10466578|RGD:2303107
Biological Process	GO:0030593	neutrophil chemotaxis	Ccl3	IDA		Rat	PMID:7722328|RGD:727687
Biological Process	GO:0001649	osteoblast differentiation	CCL3	IEP		Human	PMID:21403648
Biological Process	GO:0051928	positive regulation of calcium ion transport	CCL3	IDA		Human	PMID:15764707
Biological Process	GO:0051928	positive regulation of calcium ion transport	CCL3	IDA		Human	PMID:8699119
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	CCL3	IMP		Human	PMID:10679098
Biological Process	GO:0030335	positive regulation of cell migration	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0030335	positive regulation of cell migration	CCL3	IDA		Human	PMID:7545673
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Ccl3	IDA		Rat	PMID:10466578|RGD:2303107
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CCL3	IDA		Human	PMID:21403648
Biological Process	GO:0010628	positive regulation of gene expression	CCL3	IDA		Human	PMID:10706735
Biological Process	GO:0050729	positive regulation of inflammatory response	Ccl3	IGI	UniProtKB:P22893	Mouse	MGI:MGI:5301204|PMID:21784977
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Ccl3	IGI	UniProtKB:P22893	Mouse	MGI:MGI:5301204|PMID:21784977
Biological Process	GO:2000503	positive regulation of natural killer cell chemotaxis	CCL3	IDA		Human	PMID:7545673
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Ccl3	IGI	UniProtKB:P20060	Mouse	MGI:MGI:3044466|PMID:15155903
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Ccl3	IDA		Rat	PMID:9920817|RGD:2303108
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	CCL3	IEP		Human	PMID:21403648
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ccl3	IMP		Mouse	MGI:MGI:3044466|PMID:15155903
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ccl3	IGI	UniProtKB:P22893	Mouse	MGI:MGI:5301204|PMID:21784977
Biological Process	GO:0043491	protein kinase B signaling	CCL3	IMP		Human	PMID:21147091
Biological Process	GO:0050795	regulation of behavior	CCL3	IDA		Human	PMID:20167378
Biological Process	GO:0008360	regulation of cell shape	CCL3	IDA		Human	PMID:10072545
Biological Process	GO:0008360	regulation of cell shape	Ccl3	IDA		Mouse	MGI:MGI:3044466|PMID:15155903
Biological Process	GO:0043067	regulation of programmed cell death	Ccl3	IMP		Rat	PMID:19497618|RGD:4889991
Biological Process	GO:0051930	regulation of sensory perception of pain	CCL3	IDA		Human	PMID:15764707
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	CCL3	IDA		Human	PMID:19523456
Biological Process	GO:0070723	response to cholesterol	CCL3	IDA		Human	PMID:19523456
Biological Process	GO:0009636	response to toxic substance	CCL3	IDA		Human	PMID:10841574
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccl3	IEP		Rat	PMID:17666800|RGD:2307114
Biological Process	GO:0023052	signaling	CCL3	IEP		Human	PMID:12032188
Biological Process	GO:0010818	T cell chemotaxis	CCL3	IDA		Human	PMID:10706735

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern