Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCL5
  • Mouse genes Ccl5
  • Rat genes Ccl5
  • Zfish genes ccl35.1,ccl35.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccl5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL5	IPI	UniProtKB:P32246	Human	PMID:10660125
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL5	IPI	UniProtKB:P32246	Human	PMID:10734056
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL5	IDA		Human	PMID:10910894
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL5	IPI	UniProtKB:P32246	Human	PMID:7545673
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	CCL5	IPI	UniProtKB:P32246	Human	PMID:8699119
Molecular Function	GO:0031726	CCR1 chemokine receptor binding	Ccl5	IDA		Mouse	MGI:MGI:4943412|PMID:15557190
Molecular Function	GO:0031730	CCR5 chemokine receptor binding	CCL5	IPI	UniProtKB:P51682	Human	PMID:9139699
Molecular Function	GO:0042056	chemoattractant activity	CCL5	IDA		Human	PMID:15001559
Molecular Function	GO:0008009	chemokine activity	CCL5	IDA		Human	PMID:1699135
Molecular Function	GO:0008009	chemokine activity	Ccl5	IDA		Rat	PMID:11069838|RGD:2303112
Molecular Function	GO:0008009	chemokine activity	Ccl5	IDA		Rat	PMID:11104723|RGD:2303114
Molecular Function	GO:0046817	chemokine receptor antagonist activity	CCL5	IDA		Human	PMID:8631850
Molecular Function	GO:0042379	chemokine receptor binding	CCL5	IPI	UniProtKB:Q16570	Human	PMID:7517217
Molecular Function	GO:0042379	chemokine receptor binding	CCL5	IPI	UniProtKB:O08707	Human	PMID:9139699
Molecular Function	GO:0008201	heparin binding	Ccl5	IDA		Rat	PMID:21052646|RGD:4889872
Molecular Function	GO:0042802	identical protein binding	CCL5	IPI	UniProtKB:P13501	Human	PMID:15530372
Molecular Function	GO:0042802	identical protein binding	CCL5	IPI	UniProtKB:P13501	Human	PMID:21827949
Molecular Function	GO:0042802	identical protein binding	CCL5	IPI	UniProtKB:P13501	Human	PMID:23480650
Molecular Function	GO:0042802	identical protein binding	CCL5	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	CCL5	IDA		Human	PMID:10734056
Molecular Function	GO:0016004	phospholipase activator activity	CCL5	IDA		Human	PMID:10734056
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P51681	Human	PMID:23480650
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:O00175	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:O00585	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:O14625	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:O15444	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:O15467	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:O95715	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P02775	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P02776	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P02776:PRO_0000351217	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P02778	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P13500	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P19875	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P32246	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P47992	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P48061	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P51671	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P51681	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P78556	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P80162	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q07325	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q6UXB2	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q92583	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q99616	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q9NRJ3	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q9UBD3	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q9Y258	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:Q9Y4X3	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCL5	IPI	UniProtKB:P51681	Human	PMID:8699119
Molecular Function	GO:0042803	protein homodimerization activity	CCL5	IDA		Human	PMID:10488085
Molecular Function	GO:0004672	protein kinase activity	CCL5	IDA		Human	PMID:10734056
Molecular Function	GO:0043621	protein self-association	CCL5	IDA		Human	PMID:10488085
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity	CCL5	IDA		Human	PMID:10488085
Cellular Component	GO:0005737	cytoplasm	Ccl5	IDA		Mouse	PMID:1375672
Cellular Component	GO:0005615	extracellular space	Ccl5	IDA		Mouse	PMID:21148126
Cellular Component	GO:0005615	extracellular space	Ccl5	IDA		Mouse	PMID:22960654
Cellular Component	GO:0005615	extracellular space	Ccl5	IDA		Mouse	PMID:23460747
Cellular Component	GO:0005615	extracellular space	Ccl5	IDA		Rat	PMID:18208670|RGD:2307112
Biological Process	GO:0031584	activation of phospholipase D activity	CCL5	IDA		Human	PMID:9469451
Biological Process	GO:0007568	aging	Ccl5	IEP		Rat	PMID:16369869|RGD:2307163
Biological Process	GO:0006816	calcium ion transport	CCL5	IDA		Human	PMID:10734056
Biological Process	GO:0007267	cell-cell signaling	CCL5	IDA		Human	PMID:8558019
Biological Process	GO:0071448	cellular response to alkyl hydroperoxide	Ccl5	IEP		Rat	PMID:18478184|RGD:4890017
Biological Process	GO:0071230	cellular response to amino acid stimulus	Ccl5	IEP		Rat	PMID:20560880|RGD:4889887
Biological Process	GO:0071345	cellular response to cytokine stimulus	Ccl5	IEP		Rat	PMID:19111021|RGD:4890006
Biological Process	GO:0071361	cellular response to ethanol	Ccl5	IEP		Rat	PMID:19828633|RGD:4889979
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	CCL5	IEP		Human	PMID:9407497
Biological Process	GO:0071403	cellular response to high density lipoprotein particle stimulus	Ccl5	IEP		Rat	PMID:20623482|RGD:4889888
Biological Process	GO:0071347	cellular response to interleukin-1	CCL5	IEP		Human	PMID:9407497
Biological Process	GO:0071396	cellular response to lipid	Ccl5	IEP		Rat	PMID:20638371|RGD:4889886
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ccl5	IEP		Rat	PMID:20578038|RGD:4889899
Biological Process	GO:0071315	cellular response to morphine	Ccl5	IEP		Rat	PMID:20578038|RGD:4889899
Biological Process	GO:0071407	cellular response to organic cyclic compound	CCL5	IDA		Human	PMID:21147091
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Ccl5	IEP		Rat	PMID:20429874|RGD:4889909
Biological Process	GO:0071356	cellular response to tumor necrosis factor	CCL5	IEP		Human	PMID:9407497
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Ccl5	IEP		Rat	PMID:20663893|RGD:4889885
Biological Process	GO:0071346	cellular response to type II interferon	CCL5	IEP		Human	PMID:9407497
Biological Process	GO:0098586	cellular response to virus	CCL5	IEP		Human	PMID:28146100
Biological Process	GO:0071307	cellular response to vitamin K	Ccl5	IEP		Rat	PMID:19291322|RGD:4889997
Biological Process	GO:0070098	chemokine-mediated signaling pathway	CCL5	IDA		Human	PMID:17001303
Biological Process	GO:0002544	chronic inflammatory response	Ccl5	IEP		Rat	PMID:17164972|RGD:2307142
Biological Process	GO:0018894	dibenzo-p-dioxin metabolic process	Ccl5	IEP		Rat	PMID:20059583|RGD:4889921
Biological Process	GO:0048245	eosinophil chemotaxis	CCL5	IDA		Human	PMID:16778803
Biological Process	GO:0050673	epithelial cell proliferation	Ccl5	IMP	MGI:MGI:2180195	Mouse	PMID:23696660
Biological Process	GO:0006887	exocytosis	CCL5	IDA		Human	PMID:10734056
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	CCL5	IDA		Human	PMID:17001303
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	CCL5	IDA		Human	PMID:23979485
Biological Process	GO:0006954	inflammatory response	CCL5	IDA		Human	PMID:21147091
Biological Process	GO:0006954	inflammatory response	Ccl5	IMP	MGI:MGI:2180195	Mouse	PMID:23696660
Biological Process	GO:0006954	inflammatory response	Ccl5	IEP		Rat	PMID:12144807|RGD:2303104
Biological Process	GO:0006874	intracellular calcium ion homeostasis	CCL5	IDA		Human	PMID:10734056
Biological Process	GO:0007159	leukocyte cell-cell adhesion	CCL5	IDA		Human	PMID:8558019
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	CCL5	IDA		Human	PMID:21147091
Biological Process	GO:0048247	lymphocyte chemotaxis	Ccl5	IDA		Rat	PMID:11069838|RGD:2303112
Biological Process	GO:0048247	lymphocyte chemotaxis	Ccl5	IDA		Rat	PMID:11104723|RGD:2303114
Biological Process	GO:0000165	MAPK cascade	CCL5	IMP		Human	PMID:21147091
Biological Process	GO:0043922	negative regulation by host of viral transcription	CCL5	IDA		Human	PMID:10841574
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	CCL5	IDA		Human	PMID:10734056
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	Ccl5	IMP		Mouse	MGI:MGI:3608189|PMID:16208318
Biological Process	GO:1901215	negative regulation of neuron death	Ccl5	IMP		Rat	PMID:20578038|RGD:4889899
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	CCL5	IDA		Human	PMID:10488085
Biological Process	GO:0045071	negative regulation of viral genome replication	CCL5	IDA		Human	PMID:10490959
Biological Process	GO:0042119	neutrophil activation	CCL5	IDA		Human	PMID:10488085
Biological Process	GO:0045766	positive regulation of angiogenesis	Ccl5	IMP		Rat	PMID:18392345|RGD:4890029
Biological Process	GO:0051928	positive regulation of calcium ion transport	CCL5	IDA		Human	PMID:8699119
Biological Process	GO:0045785	positive regulation of cell adhesion	CCL5	IDA		Human	PMID:10910894
Biological Process	GO:0030335	positive regulation of cell migration	CCL5	IDA		Human	PMID:7545673
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	CCL5	IDA		Human	PMID:8558019
Biological Process	GO:0031328	positive regulation of cellular biosynthetic process	CCL5	IDA		Human	PMID:18337562
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Ccl5	IMP	MGI:MGI:2180195	Mouse	PMID:23696660
Biological Process	GO:0031622	positive regulation of fever generation	Ccl5	IDA		Rat	PMID:15066130|RGD:2307192
Biological Process	GO:0010628	positive regulation of gene expression	Ccl5	IDA		Rat	PMID:19497618|RGD:4889991
Biological Process	GO:0010628	positive regulation of gene expression	Ccl5	IMP		Rat	PMID:19559698|RGD:4889986
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion	CCL5	IDA		Human	PMID:10488085
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	CCL5	IDA		Human	PMID:16778803
Biological Process	GO:0060754	positive regulation of mast cell chemotaxis	Ccl5	IDA		Rat	PMID:18052723|RGD:4890038
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	CCL5	IDA		Human	PMID:1699135
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	CCL5	IDA		Human	PMID:19779041
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	Ccl5	IDA		Mouse	MGI:MGI:5009364|PMID:19779041
Biological Process	GO:2000503	positive regulation of natural killer cell chemotaxis	CCL5	IDA		Human	PMID:7545673
Biological Process	GO:0045666	positive regulation of neuron differentiation	Ccl5	IMP		Rat	PMID:19559698|RGD:4889986
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Ccl5	IDA		Rat	PMID:9920817|RGD:2303108
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	CCL5	IDA		Human	PMID:7544376
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Ccl5	IDA		Rat	PMID:10477596|RGD:8553666
Biological Process	GO:0042327	positive regulation of phosphorylation	CCL5	IDA		Human	PMID:18337562
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	CCL5	IDA		Human	PMID:21297082
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	CCL5	IDA		Human	PMID:21297082
Biological Process	GO:0070234	positive regulation of T cell apoptotic process	CCL5	IDA		Human	PMID:10488085
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	CCL5	IDA		Human	PMID:16778803
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	CCL5	IDA		Human	PMID:1699135
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	CCL5	IDA		Human	PMID:18337562
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	CCL5	IDA		Human	PMID:7544376
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	Ccl5	IDA		Rat	PMID:10477596|RGD:8553666
Biological Process	GO:2000406	positive regulation of T cell migration	CCL5	IDA		Human	PMID:23620790
Biological Process	GO:0042102	positive regulation of T cell proliferation	CCL5	IDA		Human	PMID:18832695
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	CCL5	IDA		Human	PMID:9417081
Biological Process	GO:0043491	protein kinase B signaling	CCL5	IMP		Human	PMID:21147091
Biological Process	GO:0031269	pseudopodium assembly	Ccl5	IDA		Rat	PMID:10477596|RGD:8553666
Biological Process	GO:0050796	regulation of insulin secretion	CCL5	IDA		Human	PMID:23979485
Biological Process	GO:1901214	regulation of neuron death	CCL5	IDA		Human	PMID:17001303
Biological Process	GO:0043067	regulation of programmed cell death	Ccl5	IMP		Rat	PMID:19497618|RGD:4889991
Biological Process	GO:0050863	regulation of T cell activation	CCL5	IDA		Human	PMID:10488085
Biological Process	GO:0014823	response to activity	Ccl5	IEP		Rat	PMID:18464247|RGD:4890018
Biological Process	GO:0097305	response to alcohol	Ccl5	IEP		Rat	PMID:11388697|RGD:14995341
Biological Process	GO:0009617	response to bacterium	Ccl5	IEP		Rat	PMID:18390738|RGD:4890031
Biological Process	GO:0070723	response to cholesterol	Ccl5	IEP		Rat	PMID:20435353|RGD:4889907
Biological Process	GO:0034097	response to cytokine	Ccl5	IDA		Mouse	PMID:1375672
Biological Process	GO:0034097	response to cytokine	Ccl5	IEP		Rat	PMID:16251240|RGD:2307170
Biological Process	GO:0043627	response to estrogen	Ccl5	IEP		Rat	PMID:20435353|RGD:4889907
Biological Process	GO:0051384	response to glucocorticoid	Ccl5	IEP		Rat	PMID:18476425|RGD:2307109
Biological Process	GO:0032868	response to insulin	Ccl5	IEP		Rat	PMID:12435855|RGD:1642005
Biological Process	GO:0032496	response to lipopolysaccharide	Ccl5	IEP		Rat	PMID:19104678|RGD:2306302
Biological Process	GO:0031667	response to nutrient levels	Ccl5	IEP		Rat	PMID:19194968|RGD:4890000
Biological Process	GO:0014070	response to organic cyclic compound	Ccl5	IEP		Rat	PMID:18375833|RGD:4890032
Biological Process	GO:0009651	response to salt stress	Ccl5	IEP		Rat	PMID:20232302|RGD:4889915
Biological Process	GO:0009636	response to toxic substance	CCL5	IDA		Human	PMID:10841574
Biological Process	GO:0034612	response to tumor necrosis factor	Ccl5	IDA		Mouse	PMID:1375672
Biological Process	GO:0034341	response to type II interferon	Ccl5	IDA		Rat	PMID:10477596|RGD:8553666
Biological Process	GO:0009615	response to virus	Ccl5	IEP		Rat	PMID:20007359|RGD:4889953
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccl5	IEP		Rat	PMID:16987901|RGD:2307144
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccl5	IEP		Rat	PMID:17666800|RGD:2307114
Biological Process	GO:0009410	response to xenobiotic stimulus	Ccl5	IEP		Rat	PMID:18469848|RGD:2307038
Biological Process	GO:0035688	T-helper 1 cell diapedesis	Ccl5	IDA		Rat	PMID:10477596|RGD:8553666

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern