Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCM2
  • Mouse genes Ccm2
  • Rat genes Ccm2
  • Zfish genes ccm2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:O00522	Human	PMID:16037064
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:O00522	Human	PMID:17657516
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q9BUL8	Human	PMID:17657516
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q9BUL8	Human	PMID:20489202
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:O00522	Human	PMID:23007647
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q9BUL8	Human	PMID:23266514
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:O00522	Human	PMID:25525273
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:O00522	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q8TEW6	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q8WVJ9	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q96N03	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:O00522	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:P31273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q13671	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCM2	IPI	UniProtKB:Q9H1K6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ccm2	IPI	UniProtKB:Q6GQS6	Mouse	PMID:19151727
Molecular Function	GO:0005515	protein binding	Ccm2	IPI	PR:Q6S5J6	Mouse	PMID:22898778
Molecular Function	GO:0005515	protein binding	Ccm2	IPI	PR:Q8VE70	Mouse	PMID:22898778
Molecular Function	GO:0005515	protein binding	Ccm2	IPI	UniProtKB:Q9ULI3	Mouse	PMID:19151727
Cellular Component	GO:0005737	cytoplasm	CCM2	IDA		Human	PMID:16037064
Cellular Component	GO:0005739	mitochondrion	CCM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	Ccm2	IDA		Mouse	PMID:19151727
Biological Process	GO:0009948	anterior/posterior axis specification	ccm2	IGI	ZFIN:ZDB-GENO-160218-8,ZFIN:ZDB-MRPHLNO-160205-1	Zfish	PMID:26540726
Biological Process	GO:0009948	anterior/posterior axis specification	ccm2	IGI	ZFIN:ZDB-GENO-160218-8,ZFIN:ZDB-MRPHLNO-160205-1,ZFIN:ZDB-MRPHLNO-160205-3	Zfish	PMID:26540726
Biological Process	GO:0001568	blood vessel development	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:1905072	cardiac jelly development	ccm2	IMP	ZFIN:ZDB-GENO-081111-4	Zfish	PMID:25625206
Biological Process	GO:0007043	cell-cell junction assembly	ccm2	IMP	ZFIN:ZDB-MRPHLNO-060821-3	Zfish	PMID:19151727
Biological Process	GO:0045216	cell-cell junction organization	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0001885	endothelial cell development	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:0001885	endothelial cell development	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0061154	endothelial tube morphogenesis	CCM2	IMP		Human	PMID:19151727
Biological Process	GO:0060047	heart contraction	ccm2	IGI	ZFIN:ZDB-GENO-160218-8,ZFIN:ZDB-MRPHLNO-160205-1	Zfish	PMID:26540726
Biological Process	GO:0007507	heart development	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0007507	heart development	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-GENO-220727-1	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	ccm2	IGI	ZFIN:ZDB-GENO-220727-1,ZFIN:ZDB-MRPHLNO-220309-5	Zfish	PMID:25625206
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-MRPHLNO-071001-1	Zfish	PMID:17623073
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-GENO-040726-1	Zfish	PMID:19652097
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-MRPHLNO-100126-3	Zfish	PMID:19542019
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-MRPHLNO-060821-3	Zfish	PMID:16873582
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-MRPHLNO-071001-2	Zfish	PMID:17623073
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-GENO-980202-253	Zfish	PMID:16873582
Biological Process	GO:0007507	heart development	ccm2	IGI	ZFIN:ZDB-GENO-160218-8,ZFIN:ZDB-MRPHLNO-160205-1,ZFIN:ZDB-MRPHLNO-160205-3	Zfish	PMID:26540726
Biological Process	GO:0007507	heart development	ccm2	IGI	ZFIN:ZDB-GENO-160218-8,ZFIN:ZDB-MRPHLNO-160205-1	Zfish	PMID:26540726
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-MRPHLNO-060821-3	Zfish	PMID:20592472
Biological Process	GO:0007507	heart development	ccm2	IMP	ZFIN:ZDB-GENO-040726-1	Zfish	PMID:20592472
Biological Process	GO:0001701	in utero embryonic development	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0001701	in utero embryonic development	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:0048839	inner ear development	Ccm2	IDA		Mouse	PMID:21795542
Biological Process	GO:0035264	multicellular organism growth	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0035264	multicellular organism growth	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:0060039	pericardium development	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0060039	pericardium development	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:1904018	positive regulation of vasculature development	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-3	Zfish	PMID:33301422
Biological Process	GO:1904018	positive regulation of vasculature development	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-2	Zfish	PMID:33301422
Biological Process	GO:1904018	positive regulation of vasculature development	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-5	Zfish	PMID:33301422
Biological Process	GO:1904018	positive regulation of vasculature development	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-4	Zfish	PMID:33301422
Biological Process	GO:0001944	vasculature development	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:0001944	vasculature development	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0001570	vasculogenesis	CCM2	IMP		Human	PMID:14740320
Biological Process	GO:0001570	vasculogenesis	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:0001570	vasculogenesis	ccm2	IMP	ZFIN:ZDB-GENO-081111-4	Zfish	PMID:18469344
Biological Process	GO:0048845	venous blood vessel morphogenesis	Ccm2	IMP	MGI:MGI:3512761	Mouse	PMID:19151727
Biological Process	GO:0048845	venous blood vessel morphogenesis	Ccm2	IGI	MGI:MGI:1924696	Mouse	PMID:19151727
Biological Process	GO:0048845	venous blood vessel morphogenesis	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-3	Zfish	PMID:33301422
Biological Process	GO:0048845	venous blood vessel morphogenesis	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-2	Zfish	PMID:33301422
Biological Process	GO:0048845	venous blood vessel morphogenesis	ccm2	IGI	ZFIN:ZDB-CRISPR-211004-2,ZFIN:ZDB-CRISPR-211004-3,ZFIN:ZDB-CRISPR-211004-4,ZFIN:ZDB-CRISPR-211004-5,ZFIN:ZDB-MRPHLNO-110525-2	Zfish	PMID:33301422
Biological Process	GO:0048845	venous blood vessel morphogenesis	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-5	Zfish	PMID:33301422
Biological Process	GO:0048845	venous blood vessel morphogenesis	ccm2	IMP	ZFIN:ZDB-CRISPR-211004-4	Zfish	PMID:33301422

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern