Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCN1
  • Mouse genes Ccn1
  • Rat genes Ccn1
  • Zfish genes ccn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050840	extracellular matrix binding	Ccn1	IDA		Mouse	PMID:18757743
Molecular Function	GO:0005178	integrin binding	Ccn1	IDA		Mouse	PMID:12826661
Molecular Function	GO:0005515	protein binding	CCN1	IPI	UniProtKB:O60906	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN1	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CCN1	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CCN1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ccn1	HDA		Mouse	MGI:MGI:5582867|PMID:23658023
Biological Process	GO:0006915	apoptotic process	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:17023674
Biological Process	GO:0003278	apoptotic process involved in heart morphogenesis	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:17023674
Biological Process	GO:0060413	atrial septum morphogenesis	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:17023674
Biological Process	GO:0003181	atrioventricular valve morphogenesis	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:17023674
Biological Process	GO:0007155	cell adhesion	Ccn1	IDA		Mouse	PMID:12826661
Biological Process	GO:0007155	cell adhesion	Ccn1	IDA		Rat	PMID:11897702|RGD:727633
Biological Process	GO:0098609	cell-cell adhesion	Ccn1	IDA		Mouse	PMID:9441684
Biological Process	GO:0006935	chemotaxis	Ccn1	IDA		Rat	PMID:11897702|RGD:727633
Biological Process	GO:0060591	chondroblast differentiation	Ccn1	IDA		Mouse	PMID:9441684
Biological Process	GO:0060710	chorio-allantoic fusion	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:12446788
Biological Process	GO:0030198	extracellular matrix organization	Ccn1	IDA		Mouse	PMID:18757743
Biological Process	GO:0031101	fin regeneration	ccn1	IMP	ZFIN:ZDB-GENO-190110-9	Zfish	PMID:28871129
Biological Process	GO:0002041	intussusceptive angiogenesis	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:12446788
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:12446788
Biological Process	GO:0043066	negative regulation of apoptotic process	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:17023674
Biological Process	GO:0001649	osteoblast differentiation	Ccn1	IGI	MGI:MGI:98956	Mouse	PMID:16581771
Biological Process	GO:0043065	positive regulation of apoptotic process	Ccn1	IGI	UniProtKB:O60906	Mouse	PMID:19364818
Biological Process	GO:0043065	positive regulation of apoptotic process	Ccn1	IGI	UniPRotKB:P48023	Mouse	PMID:19364818
Biological Process	GO:0043065	positive regulation of apoptotic process	Ccn1	IGI	UniProtKB:P23229	Mouse	PMID:19364818
Biological Process	GO:0043065	positive regulation of apoptotic process	Ccn1	IGI	UniProtKB:P05556	Mouse	PMID:19364818
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	CCN1	IGI	UniProtKB:P21274	Human	PMID:20675382
Biological Process	GO:0030501	positive regulation of bone mineralization	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:0061036	positive regulation of cartilage development	Ccn1	IMP		Mouse	PMID:9441684
Biological Process	GO:0045597	positive regulation of cell differentiation	Ccn1	IDA		Mouse	PMID:9441684
Biological Process	GO:0030335	positive regulation of cell migration	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:0030335	positive regulation of cell migration	Ccn1	IDA		Mouse	PMID:16581771
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Ccn1	IDA		Mouse	PMID:18757743
Biological Process	GO:2000304	positive regulation of ceramide biosynthetic process	Ccn1	IDA		Mouse	PMID:19364818
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Ccn1	IMP		Rat	PMID:27653023|RGD:150429754
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Ccn1	IGI	UniProtKB:P48023	Mouse	PMID:19364818
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Ccn1	IMP		Rat	PMID:27653023|RGD:150429754
Biological Process	GO:0032740	positive regulation of interleukin-17 production	Ccn1	IMP		Rat	PMID:27653023|RGD:150429754
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ccn1	IMP		Rat	PMID:27653023|RGD:150429754
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:0010518	positive regulation of phospholipase activity	Ccn1	IDA		Mouse	PMID:19364818
Biological Process	GO:0045860	positive regulation of protein kinase activity	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	Ccn1	IMP		Rat	PMID:27653023|RGD:150429754
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ccn1	IMP		Rat	PMID:27653023|RGD:150429754
Biological Process	GO:0072593	reactive oxygen species metabolic process	Ccn1	IDA		Mouse	PMID:19364818
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	CCN1	IDA		Human	PMID:20675382
Biological Process	GO:0003281	ventricular septum development	Ccn1	IMP	MGI:MGI:2446577	Mouse	PMID:17023674
Biological Process	GO:0044319	wound healing, spreading of cells	CCN1	IDA		Human	PMID:20675382

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern