Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ccn2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CCN2
- Mouse genes Ccn2
- Rat genes Ccn2
- Zfish genes ccn2a,ccn2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001968	fibronectin binding	Ccn2	IDA		Rat	PMID:18167060\|RGD:2314623
Molecular Function	GO:0008083	growth factor activity	Ccn2	IDA		Rat	PMID:10026205\|RGD:632526
Molecular Function	GO:0008201	heparin binding	Ccn2	IDA		Mouse	PMID:9184077
Molecular Function	GO:0005178	integrin binding	Ccn2	IDA		Mouse	PMID:10446209
Molecular Function	GO:0005515	protein binding	CCN2	IPI	UniProtKB:P02751	Human	PMID:16457822
Molecular Function	GO:0005515	protein binding	CCN2	IPI	UniProtKB:P03372	Human	PMID:21629692
Molecular Function	GO:0005515	protein binding	CCN2	IPI	UniProtKB:Q92731	Human	PMID:21629692
Molecular Function	GO:0005515	protein binding	CCN2	IPI	UniProtKB:Q8CBR6	Human	PMID:30232710
Molecular Function	GO:0005515	protein binding	CCN2	IPI	UniProtKB:P23142-4	Human	PMID:9927660
Cellular Component	GO:0005938	cell cortex	Ccn2	IDA		Rat	PMID:19359517\|RGD:2314527
Cellular Component	GO:0005801	cis-Golgi network	Ccn2	IDA		Rat	PMID:11697887\|RGD:2314663
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CCN2	HDA		Human	PMID:28327460
Cellular Component	GO:0005829	cytosol	Ccn2	IDA		Rat	PMID:19381071\|RGD:2314513
Cellular Component	GO:0031012	extracellular matrix	Ccn2	IDA		Mouse	PMID:9184077
Cellular Component	GO:0005576	extracellular region	Ccn2	IDA		Mouse	PMID:1888698
Cellular Component	GO:0005615	extracellular space	Ccn2	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Ccn2	IDA		Rat	PMID:19570811\|RGD:2314490
Cellular Component	GO:0005794	Golgi apparatus	CCN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CCN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ccn2	IDA		Rat	PMID:19359517\|RGD:2314527
Biological Process	GO:0007568	aging	Ccn2	IEP		Rat	PMID:15147944\|RGD:2314657
Biological Process	GO:0001525	angiogenesis	Ccn2	IDA		Mouse	PMID:10446209
Biological Process	GO:0001525	angiogenesis	Ccn2	IDA		Mouse	PMID:10082563
Biological Process	GO:0001525	angiogenesis	Ccn2	IMP	MGI:MGI:2663631	Mouse	PMID:12736220
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	Ccn2	IMP		Rat	PMID:19707545\|RGD:2314476
Biological Process	GO:0001502	cartilage condensation	Ccn2	IDA		Mouse	PMID:15305294
Biological Process	GO:0016477	cell migration	Ccn2	IDA		Mouse	PMID:10082563
Biological Process	GO:0007160	cell-matrix adhesion	Ccn2	IDA		Mouse	PMID:9184077
Biological Process	GO:0071398	cellular response to fatty acid	Ccn2	IEP		Rat	PMID:19625611\|RGD:2314487
Biological Process	GO:0071333	cellular response to glucose stimulus	Ccn2	IEP		Rat	PMID:19625611\|RGD:2314487
Biological Process	GO:0002062	chondrocyte differentiation	Ccn2	IDA		Mouse	PMID:15305294
Biological Process	GO:0035988	chondrocyte proliferation	Ccn2	IMP	MGI:MGI:2663631	Mouse	PMID:18597638
Biological Process	GO:0043009	chordate embryonic development	ccn2a	IMP	ZFIN:ZDB-MRPHLNO-081013-1	Zfish	PMID:16950203
Biological Process	GO:0043009	chordate embryonic development	ccn2a	IMP	ZFIN:ZDB-MRPHLNO-081013-2	Zfish	PMID:16950203
Biological Process	GO:0061448	connective tissue development	Ccn2	IMP	MGI:MGI:4949916	Mouse	PMID:23839921
Biological Process	GO:0060216	definitive hemopoiesis	ccn2a	IMP	ZFIN:ZDB-MRPHLNO-150126-6	Zfish	PMID:31042481
Biological Process	GO:0007492	endoderm development	ccn2a	IMP	ZFIN:ZDB-MRPHLNO-150126-6	Zfish	PMID:25313964
Biological Process	GO:0070278	extracellular matrix constituent secretion	Ccn2	IMP		Rat	PMID:18613219\|RGD:2314619
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ccn2	IDA		Mouse	PMID:9184077
Biological Process	GO:0007229	integrin-mediated signaling pathway	Ccn2	IDA		Mouse	PMID:10446209
Biological Process	GO:0007229	integrin-mediated signaling pathway	Ccn2	IDA		Mouse	PMID:10082563
Biological Process	GO:0035556	intracellular signal transduction	Ccn2	IDA		Rat	PMID:12193543\|RGD:628364
Biological Process	GO:0030324	lung development	Ccn2	IMP	MGI:MGI:2663631	Mouse	PMID:18213577
Biological Process	GO:0030324	lung development	Ccn2	IEP		Rat	PMID:19361631\|RGD:2314526
Biological Process	GO:0007019	microtubule depolymerization	Ccn2	IMP		Rat	PMID:20858895\|RGD:7242937
Biological Process	GO:0010629	negative regulation of gene expression	Ccn2	IMP	MGI:MGI:2663631	Mouse	PMID:18597638
Biological Process	GO:0030903	notochord development	ccn2a	IMP	ZFIN:ZDB-MRPHLNO-081013-1	Zfish	PMID:16950203
Biological Process	GO:0030903	notochord development	ccn2a	IMP	ZFIN:ZDB-MRPHLNO-081013-2	Zfish	PMID:16950203
Biological Process	GO:0001503	ossification	Ccn2	IMP		Mouse	PMID:11237711
Biological Process	GO:0001503	ossification	Ccn2	IMP	MGI:MGI:2663631	Mouse	PMID:12736220
Biological Process	GO:0043065	positive regulation of apoptotic process	Ccn2	IMP		Rat	PMID:19625611\|RGD:2314487
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	Ccn2	IMP		Rat	PMID:19707545\|RGD:2314476
Biological Process	GO:0050867	positive regulation of cell activation	Ccn2	IMP		Rat	PMID:18613219\|RGD:2314619
Biological Process	GO:0045597	positive regulation of cell differentiation	CCN2	IDA		Human	PMID:20008146
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ccn2	IMP		Rat	PMID:19570811\|RGD:2314490
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Ccn2	IMP		Rat	PMID:19570811\|RGD:2314490
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Ccn2	IMP		Rat	PMID:19625611\|RGD:2314487
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CCN2	IDA		Human	PMID:20008146
Biological Process	GO:0070318	positive regulation of G0 to G1 transition	Ccn2	IMP		Rat	PMID:18613219\|RGD:2314619
Biological Process	GO:0010628	positive regulation of gene expression	Ccn2	IMP		Rat	PMID:19570811\|RGD:2314490
Biological Process	GO:0046330	positive regulation of JNK cascade	CCN2	IDA		Human	PMID:20008146
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Ccn2	IMP		Rat	PMID:19707545\|RGD:2314476
Biological Process	GO:0051496	positive regulation of stress fiber assembly	CCN2	IDA		Human	PMID:20008146
Biological Process	GO:0072593	reactive oxygen species metabolic process	Ccn2	IDA		Mouse	PMID:19364818
Biological Process	GO:0031099	regeneration	ccn2a	IMP	ZFIN:ZDB-GENO-170127-4	Zfish	PMID:27811277
Biological Process	GO:0031099	regeneration	ccn2a	IMP	ZFIN:ZDB-GENO-170127-7	Zfish	PMID:27811277
Biological Process	GO:0031099	regeneration	ccn2a	IMP	ZFIN:ZDB-GENO-170127-8	Zfish	PMID:27811277
Biological Process	GO:0032330	regulation of chondrocyte differentiation	Ccn2	IMP	MGI:MGI:2663631	Mouse	PMID:18597638
Biological Process	GO:0043200	response to amino acid	Ccn2	IEP		Rat	PMID:17250813\|RGD:1625511
Biological Process	GO:0034059	response to anoxia	Ccn2	IEP		Rat	PMID:18929865\|RGD:2314608
Biological Process	GO:0032355	response to estradiol	Ccn2	IEP		Rat	PMID:19509476\|RGD:2314504
Biological Process	GO:0070542	response to fatty acid	Ccn2	IEP		Rat	PMID:19656915\|RGD:2314484
Biological Process	GO:0051385	response to mineralocorticoid	Ccn2	IEP		Rat	PMID:19521108\|RGD:2314503
Biological Process	GO:0014070	response to organic cyclic compound	Ccn2	IEP		Rat	PMID:19558898\|RGD:2314502
Biological Process	GO:0043434	response to peptide hormone	Ccn2	IEP		Rat	PMID:19667256\|RGD:2314482
Biological Process	GO:0001894	tissue homeostasis	Ccn2	IMP	MGI:MGI:4949916	Mouse	PMID:23839921

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.