Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCN3
  • Mouse genes Ccn3
  • Rat genes Ccn3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	CCN3	IPI	UniProtKB:P05106|UniProtKB:P08648	Human	PMID:12695522
Molecular Function	GO:0005178	integrin binding	CCN3	IPI	UniProtKB:P05556|UniProtKB:P06756	Human	PMID:12695522
Molecular Function	GO:0005178	integrin binding	CCN3	IPI	UniProtKB:P06756|UniProtKB:P18084	Human	PMID:15611078
Molecular Function	GO:0005112	Notch binding	CCN3	IPI	UniProtKB:Q01705	Human	PMID:12050162
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:P08050	Human	PMID:15181016
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:P08050	Human	PMID:15213231
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:P49639	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:O43559	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:P27658	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q12837	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q5T7P2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q6L8G9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q6NUJ2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q6P9E2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q86YD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q8IV28	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q8N5G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q96KP6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q9BWW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q9BYE3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:Q9Y3S2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:X5D778	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCN3	IPI	UniProtKB:P23142-4	Human	PMID:9927660
Cellular Component	GO:0030424	axon	Ccn3	IDA		Rat	PMID:19286457|RGD:2306292
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ccn3	IDA		Rat	PMID:19286457|RGD:2306292
Cellular Component	GO:0005737	cytoplasm	CCN3	IMP		Human	PMID:15181016
Cellular Component	GO:0005737	cytoplasm	Ccn3	IDA		Rat	PMID:15213231|RGD:10400864
Cellular Component	GO:0030425	dendrite	Ccn3	IDA		Rat	PMID:19286457|RGD:2306292
Cellular Component	GO:0005576	extracellular region	Ccn3	IDA		Rat	PMID:15213231|RGD:10400864
Cellular Component	GO:0005615	extracellular space	Ccn3	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005921	gap junction	CCN3	IMP		Human	PMID:15181016
Cellular Component	GO:0005921	gap junction	Ccn3	IDA		Rat	PMID:15213231|RGD:10400864
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CCN3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043025	neuronal cell body	Ccn3	IDA		Rat	PMID:19286457|RGD:2306292
Biological Process	GO:0001525	angiogenesis	CCN3	IDA		Human	PMID:12695522
Biological Process	GO:1990523	bone regeneration	Ccn3	IMP		Mouse	MGI:MGI:5504324|PMID:23653360
Biological Process	GO:0033627	cell adhesion mediated by integrin	CCN3	IDA		Human	PMID:12695522
Biological Process	GO:0033627	cell adhesion mediated by integrin	CCN3	IDA		Human	PMID:15611078
Biological Process	GO:0060326	cell chemotaxis	CCN3	IDA		Human	PMID:15611078
Biological Process	GO:0002062	chondrocyte differentiation	CCN3	IMP		Human	PMID:21871891
Biological Process	GO:0002062	chondrocyte differentiation	Ccn3	IMP		Rat	PMID:21871891|RGD:10400852
Biological Process	GO:0035767	endothelial cell chemotaxis	CCN3	IDA		Human	PMID:12695522
Biological Process	GO:0071603	endothelial cell-cell adhesion	CCN3	IDA		Human	PMID:12695522
Biological Process	GO:0010761	fibroblast migration	CCN3	IDA		Human	PMID:15611078
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	CCN3	IMP		Human	PMID:17463287
Biological Process	GO:0030308	negative regulation of cell growth	CCN3	IMP		Human	PMID:15181016
Biological Process	GO:1902731	negative regulation of chondrocyte proliferation	CCN3	IMP		Human	PMID:21871891
Biological Process	GO:0050728	negative regulation of inflammatory response	Ccn3	IMP		Mouse	MGI:MGI:5604651|PMID:24722330
Biological Process	GO:0046676	negative regulation of insulin secretion	Ccn3	IDA		Mouse	MGI:MGI:5517610|PMID:23705021
Biological Process	GO:0090027	negative regulation of monocyte chemotaxis	CCN3	IMP		Human	PMID:21063504
Biological Process	GO:0010832	negative regulation of myotube differentiation	CCN3	IDA		Human	PMID:12050162
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	CCN3	IMP		Human	PMID:21063504
Biological Process	GO:1904057	negative regulation of sensory perception of pain	Ccn3	IMP		Rat	PMID:22353423|RGD:10400878
Biological Process	GO:0060392	negative regulation of SMAD protein signal transduction	Ccn3	IMP		Mouse	MGI:MGI:5504324|PMID:23653360
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	CCN3	IDA		Human	PMID:12050162
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	CCN3	IDA		Human	PMID:20139355
Biological Process	GO:0010468	regulation of gene expression	Ccn3	IDA		Rat	PMID:18597638|RGD:8554669
Biological Process	GO:0014909	smooth muscle cell migration	CCN3	IDA		Human	PMID:20139355
Biological Process	GO:0048659	smooth muscle cell proliferation	CCN3	IDA		Human	PMID:20139355
Biological Process	GO:0048659	smooth muscle cell proliferation	Ccn3	IMP		Mouse	MGI:MGI:5004757|PMID:20139355
Biological Process	GO:0044342	type B pancreatic cell proliferation	Ccn3	IDA		Mouse	MGI:MGI:5517610|PMID:23705021

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern